Golgi Body

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noun Cell Biology . an organelle, consisting of layers of flattened sacs, that takes up and processes secretory and synthetic products from the endoplasmic reticulum and then either releases the finished products into various parts of the cell cytoplasm or secretes them to the outside of the cell. Golgi Body

History…: 

History… It was discovered in 1897 by a man named Camillo Golgi… who was blessed with a large mustache. Some people questioned his discovery but with advances of technology it was eventually confirmed.

The Golgi body…: 

The Golgi body… The Golgi body is an organelle in the cell. It is made up of flattened membrane sacs, called cisternae. These sacs are not connected to each other and there are usually 3-8 in the Golgi body, the sacs are stacked like plates. This organelle is also part of the endomembrane system, which means it has a membrane and is involved in the transport of proteins and other vesicles

Function…: 

Function… The Golgi’s main job is to take in proteins from the endoplasmic reticulum (ER), modify them slightly, and then ‘re-package’ them in new vesicles for exocytosis (secretion ) For this reason, the Golgi is often thought of and called the Post Office of the cell. It also transports lipids and makes lysosomes

Logistics…: 

Logistics… Vesicles carrying proteins leave the ER and enter the Golgi through the cis face of the organelle, which is usually located very close to the ER.

Logistics…: 

Logistics… Once the vesicles merge with the Golgi body the Golgi body modifies the protein. This modification happens as the protein moves through the layers of cisternae and the space between them, which is called the lumen. These proteins are modified using enzymes in the cisternae that add molecules such as carbohydrates or phosphates. While these molecules don’t change the proteins shape and therefore function they do act as a label telling the cell where the protein needs to go.

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Lumen

Logistics…: 

Logistics… After traveling through these cisternae the newly tagged proteins are sorted by their various destinations (different organelles…out of the cell… ect .) Then, they exit the cell through the trans face, or the opposite side of the organelle. This happens by the Golgi budding off into new vesicles headed for their destinations as determined by the Golgi.

Diseases: I-Cell… : 

Diseases: I-Cell… I-cell disease also called Mucolipidosis II is a disease where the proteins in the Golgi malfunction and label the proteins incorrectly, not adding a phosphate where there should be one. This additional phosphate tells the Golgi body to send that protein outside of the cell, instead of to the lysosome where it belongs.

Diseases: I-Cell… : 

Diseases: I-Cell… When the lysosome does not have this protein, which is a digestive enzyme, it can not do its job and waste substances start to build up in the cell. Children born with the disease usually have enlarged livers and spleens and do not tend to live past the age of 7.

Diseases: Alzheimer’s… : 

Diseases: Alzheimer’s… Recently some scientists have linked Golgi body abnormalities and Alzheimer's disease . In their research they found that in many of the Alzheimer’s patients, the Golgi bodies in their neurons were not shaped normally, with the flattened pancakes stacked like plates, but instead more like separated spheres that are not close together.

Works cited…: 

Works cited… http://www.medscape.com/medline/abstract/8579105...10/14/12 http://dictionary.reference.com/browse/Golgi+Apparatus...10/14/12 http://scienceray.com/biology/golgi-apparatus/#ixzz291OyBiMQ)...12/14/12

Works cited…: 

Works cited… http://en.wikipedia.org/wiki/Cisterna...10/14/12 http://en.wikipedia.org/wiki/Golgi_body...10/14/12 http://www.brighthub.com/science/genetics/articles/22922.aspx...10/14/12 Campbell, Neil A., and Jane B. Reece. Biology . San Francisco: Benjamin Cummings, 2002. Print.

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