Pharm 118 (Week 2) - Ch 17 Pt 1

Adrenergic Drugs :Adrenergic Drugs Chapter 17 1


Adrenergic Drugs :Adrenergic Drugs Mimic the effects of the SNS neurotransmitters: norepinephrine (NE) epinephrine (EPI) dopamine Adrenergic agonists Sympathomimetic drugs 2


Adrenergic Drugs :Adrenergic Drugs Located throughout the body Are receptors for the sympathetic neurotransmitters  (alpha)-adrenergic receptors  (beta)-adrenergic receptors Dopaminergic receptors: respond only to dopamine 3


Adrenergic Receptors :Adrenergic Receptors Predominant -Adrenergic Agonist Responses Vasoconstriction CNS stimulation 4


-Adrenergic Receptors :-Adrenergic Receptors 1-adrenergic receptors—located primarily in the heart 2-adrenergic receptors—located in smooth muscle of the bronchioles, arterioles, and visceral organs 5


Catecholamines :Catecholamines Substances that can produce a sympathomimetic response Norepinephrine Epinephrine Dopamine 6


Adrenergic Drugs :Adrenergic Drugs Alpha- and Beta- Adrenergic Agonists Epinephrine (Adrenalin, others) Norepinephrine (Levophed) Dopamine (Intropin) Dobutamine (Dobutrex) Ephedrine (Pretz-D) 7


Adrenergic Drugs :Adrenergic Drugs Alpha- and Beta- Adrenergic Agonists Epinephrine (Adrenalin, others) Treatment of shock Bronchospasm Ophthalmic agent Prolongs the effects of local anesthetics 8


Adrenergic Drugs :Adrenergic Drugs Alpha- and Beta- Adrenergic Agonists Norepinephrine (Levophed) Given IV Treatment of shock Cardiac arrest 9


Adrenergic Drugs :Adrenergic Drugs Alpha- and Beta- Adrenergic Agonists Dopamine (Intropin) Treatment of shock Stimulates the heart Renal and splanchnic arteriole dilation 10


Adrenergic Drugs :Adrenergic Drugs Alpha- and Beta- Adrenergic Agonists Dobutamine (Dobutrex) Preference for beta1 receptor sites Treatment of congestive heart failure 11


Adrenergic Drugs :Adrenergic Drugs Alpha- and Beta- Adrenergic Agonists Ephedrine (Pretz-D) Stimulates the release of norepinephrine Acts directly on adrenergic receptor sites Nasal decongestant 12


Alpha- and Beta- Adrenergic Agonists :Alpha- and Beta- Adrenergic Agonists Therapeutic Actions and Indications Increased heart rate Increased myocardial contractility Bronchi dilate Increased respirations, rate and depth Vasoconstriction (increased Blood pressure) Decreased intraocular pressure (pupils dilate) Glycogenolysis Increased sweating 13


Alpha- and Beta- Adrenergic Agonists :Alpha- and Beta- Adrenergic Agonists Contraindications and Cautions Tachyarrhythmias Pheochromocytoma Ventricular fibrillation Hypovolemia Anesthetics Peripheral vascular disease 14


Alpha- and Beta- Adrenergic Agonists :Alpha- and Beta- Adrenergic Agonists Adverse Effects Arrhythmias Hypertension Palpitations Angina Dyspnea Nausea and vomiting Headache, sweating, piloerection 15