safety of intracameral moxifloxacin after cataract. surgery

Assessment of safety of Intracameral Moxifloxacin in Cataract surgery : 

Assessment of safety of Intracameral Moxifloxacin in Cataract surgery AUTHOR-DR PRAVEEN DESHPANDE POST GRADUATE COAUTHOR- DR MANOHAR MEHTA, DR G. PAVAN Department Of Ophthalmology VIMS, Bellary PRAVEEN Deshpande

PURPOSE : 

PURPOSE To assess the effect of intracameral Moxifloxacin anterior chamber reaction endothelial cell count corneal thickness

MATERIALS : 

MATERIALS Moxifloxacin- 0.5% eye drops Broad spectrum Rapidly bactericidal Improved penetration Preservative free

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ph of 6.8 osmolality of 290 mOsm/kg Higher AH conc above MIC Better MIC in vitreous

METHOD : 

METHOD Prospective study No. of cases- 50 patients

Exclusion criteria : 

Exclusion criteria Hypermature cataract Cataract a/w other ocular abnormality

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Preoperative assessment Routine ocular examination - Nucleus grading ( LOCS III) - Endothelial cell counts* - corneal thickness

Procedure : 

Procedure small incision cataract surgery with PCIOL 0.1 mL of 0.5% moxifloxacin (500 μ g) solution injected intracamerally at the end of the surgery.

Video : 

Video

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Postoperative assessment The patients - follow-up 1 day, 1 week, and 1 month after surgery.

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Results : 

Results 50 patients completed the study. The mean endothelial cell count - preoperatively - 2378 cells/mm2 postoperatively - 2164 cells/mm2 Mean difference- 214cells/mm2, which not statistically significant The mean pachymetry preoperatively - 0.489 mm postoperatively- 0.503 mm The increase of 0.14 mm in postoperative pachymetry after 1 month.

Mean age : 

Mean age

Specular Microscopy : 

Specular Microscopy Pre-op Post-op

Endothelial cell count ( normal-4-15%) ( n-50, p>0.05) : 

Endothelial cell count ( normal-4-15%) ( n-50, p>0.05)

Corneal thickness (n-50, p>0.05) : 

Corneal thickness (n-50, p>0.05)

AC cells : 

AC cells

Visual acuity : 

Visual acuity

Conclusion : 

Conclusion Nontoxic Safe for prophylaxis in cataract surgery

References : 

References J Cataract Refract Surg. 2007;33:978–988 J Cataract Refract Surg. 2007;33:1801–1805 Journal of Cataract & Refractive Surgery June 2002 (Vol. 28, Issue 6, Pages 982-987) J Cataract Refract Surg 1998; 24:725–726 Journal of Cataract & Refractive Surgery .January 2007 (Vol. 33, Issue 1, Pages 63-68)

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Thank you