Role of Nuclear Medicine/Molecular medicine/ Molecular imaging & therapeutics:
Role of Nuclear Medicine/Molecular medicine/ Molecular imaging & therapeutics Safest, painless & cost-effective branch of medicine and medical imaging. utilize gamma ray from radionuclides with or without pharmaceutical compounds image disease process at an earlier stage, based on physiology Ablate diseased tissue by beta particle. John H. Lawrence first use P 32 to treat leukemia in 1936
Role of Nuclear Medicine/Molecular medicine/ Molecular imaging & therapeutics:
Role of Nuclear Medicine/Molecular medicine/ Molecular imaging & therapeutics 3 Core Components in NM imaging: Radionuclides (relatively short-lived) Gamma camera (used in scintigraphy, SPECT & PET) Computer (Software) Examples of NM Imaging: Organ specific like Brain, Heart, Lung, Liver, Thyroid, Parathyroid etc. Whole body imaging, based on cellular receptors, like whole body PET or PET/CT scan, gallium scan, indium scan, MIBG and octreotide/somatostatin receptor scan. David E. Kuhl invented the concept of emission & transmission tomography in 1962 which led design of SPECT,PET, CT & their fusions.
Role of Nuclear Medicine/Molecular medicine/ Molecular imaging & therapeutics:
Role of Nuclear Medicine/Molecular medicine/ Molecular imaging & therapeutics Examples of NM therapy: 131 I for hyperthyroidism and thyroid cancer, Yttrium-90(Zevalin) and Iodine-131(Bexxar) for refractory Lymphoma, 131I-MIBG for neuroendocrine tumors, palliative bone pain treatment with Samarium-153 or Strontium-89 implanted capsules of isotopes (brachytherapy) to treat cancer. Upper L-PET, Upper R-PET/MRI, Lower-PET/CT (1996) (2008) (2008)
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