FATTY ACID OXIDATION

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Fatty acid Catabolism (b-oxidation)

Import of acyl-CoA into mitochondria:

Import of acyl-CoA into mitochondria

b-oxidation:

b-oxidation

b-oxidation:

b-oxidation B-oxidation of palmitate (C16:0) yields 106 molecules of ATP C 16:0-CoA + 7 FAD + 7 NAD + + 7 H 2 0 + 7 CoA  8 acetyl-CoA + 7 FADH 2 + 7 NADH + 7 H +

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2.5 ATPs per NADH = 17.5 1.5 ATPs per FADH2 = 10.5 10 ATPs per acetyl-CoA = 80 Total = 108 ATPs 2 ATP equivalents (ATP AMP + PPi, PPi  2 Pi) consumed during activation of palmitate to acyl-CoA Net yield = 106 ATPs

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Acyl-CoA Dehydrogenase

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X

b-oxidation of odd chain fatty acids:

b-oxidation of odd chain fatty acids

b-oxidation of unsaturated fatty acids:

b-oxidation of unsaturated fatty acids

b-oxidation of fatty acids with even numbered double bonds:

b-oxidation of fatty acids with even numbered double bonds

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Formation of ketone bodies

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Re-utilization of ketone bodies

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