logging in or signing up plasma proteins drhari Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Copy Does not support media & animations WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 714 Category: Science & Tech.. License: Some Rights Reserved Like it (0) Dislike it (0) Added: December 30, 2010 This Presentation is Public Favorites: 0 Presentation Description hi ppl. pls comment after downloading this file. search for drhari in authorstream and you can download my Biochemistry ppts or 'follow' me for new uploads. share the knowledge. Comments Posting comment... By: hamzasol (20 month(s) ago) Can I have it please Saving..... Post Reply Close Saving..... Edit Comment Close Premium member Presentation Transcript Plasma proteins : Plasma proteins Dr. Hariharan Slide 2: Blood volume- 4.5 to 5 litres. Centrifuge- upper plasma Plasma- 55-60% Protein content- 6-8 gm/ 100ml All ptns except immunoglobulins synthesized by liver Albumin : Albumin Mol wt- 69,000 Synthesized by liver Half life- 20 days Blood level- 3.5 to 5 g/dl Functions of albumin-1.Osmotic pressure : Functions of albumin-1.Osmotic pressure Colloid osmotic pressure of plasma- 278-305 mosm/kg Exerted by –Na+ - but crosses freely Proteins- large- cannot escape Starling’s hypothesis At capillary end- BP expels water out Effective osmotic pressure takes the water in Slide 5: 10 mm Hg out E.O.Press- 25 BP-35 mmhg BP-10 mmhg E.O.Press- 25 10 mm Hg in 2.Transport function : 2.Transport function Bilirubin Non-esterified fatty acids Drugs-sulphonamides, aspirin, salicylate, dicoumarol, phenytoin Hormones-steroid hormones, thyroxine Metals- calcium, copper, heavy metals Only unbound fractions are active Slide 7: 3.Buffering action 4.Nutritional function- all cells take up albumin. Consider as transport of a.a Clinical applications : Clinical applications Blood brain barrier- fatty acids,bilirubin-albumin Drug interactions- phenytoin, dicoumarol Protein-Bound Calcium- hypoalbuminemia- low Ca+ Therapeutic Use- shock, Hge, burns Hypoalbuminemia : Hypoalbuminemia Causes: Cirrhosis of liver Malnutrition Nephrotic syndrome Albumiuria- nephrotic syndrome, acute nephritis Protein losing Enteropathy Congestive cardiac failure A:G ratio-compensatory inc in globulins Transport Proteins : Transport Proteins Albumin: FFA, bilirubin, drugs, Ca+ Pre-Albumin or Transthyretin- thyroxin RBP-Retinol binding protein Thyroxine Binding Globulin(TBG) Transcortin(cortisol binding globulin) Haptoglobin- hemoglobin Transferrin Lipoproteins Polymorphism : Polymorphism Protein that exists in different phenotypes in population, but only one form seen in a particular person Almost all ptns Haptoglobin- Hp1-1, Hp2-1, Hp2-2 Acute Phase Proteins : Acute Phase Proteins CRP:C-Reactive Protein C- polysaccharide capsule of pneumococci Beta globulin Liver Inc in inflammatory states High sensitivity CRP- cardiac risk predictor Slide 13: 2. Ceruloplasmin Liver Has 6-8 copper atoms Also called ferroxidase- incorporates iron into transferrin 90% copper is bound Low levels- Wilson’s disease, malnutrition, nephrosis, cirrhosis Inc in inflammatory conditions Slide 14: 3. a-1Antitrypsin(AAT) Inhibits all serine proteases- plasmin, chymotrypsin, elastase, cathepsin Emphysema Nephrotic syndrome-AAT lost 4. a-2Macroglobulin Hepatocytes and macrophages Anticoagulant Inc in nephrotic syndrome Negative Acute Phase Proteins : Negative Acute Phase Proteins Ex: Albumin, Transthyretin, RBP, Transferrin Slide 16: XII ###### ############ XII a XI a IX fibrin XI II II a X a fibrinogen X IX a X tissue factor Ca+ Slide 17: PROTHROMBIN Zymogen Prothombin- by Xa- removal of terminal fragment-Ca+ binding site cleaved-converted to Thrombin 10-15mg/ dl FIBRINOGEN Becomes fibrin during clotting mechanism Fibrinolysis: TPAplasminogen Plasmindissolves clots Streptokinase, Urokinase Abnormalities in Coagulation : Abnormalities in Coagulation Hemophilia A X linkes- males Deficiency Factor VIII Prolonged clotting time Excessive bleeding Old treatment-Blood transfusions Now- recombinant factor VIII Hemophilia B- Factor IX- Christmas disease Patterns in serum electrophoresis : Patterns in serum electrophoresis normal α2 α1 β γ alb α2 α1 β γ alb Nephrotic Syndrome α2 α1 β γ alb Multiple Myeloma Slide 20: Thank you You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.