protein metabolism- Hydroxy aminoacids

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Protein metabolism-Hydroxy aminoacids:

Protein metabolism- Hydroxy aminoacids Dr. Hariharan . V Assistant Professor, Dept of Biochemistry Karpagam faculty of medical sciences Coimbatore

Objectives :

Objectives At the end of this session you should able to describe Sources of serine Catabolism of serine Functions of Serine

Serine:

Serine Aliphatic hydroxy aminoacid Non essential and glucogenic

Formation of Serine:

Formation of Serine From phosphoglycerate From Glycine by reversal of Serine hydroxy methyl transferase Transamination Ala + Hydroxy pyruvate  Pyruvate + serine

Catabolism of serine:

Catabolism of serine Transamination to pyruvate Transamination to hydroxy pyruvate Glucogenic

Functions of serine:

Functions of serine One carbon metabolism  methylene THFA Cysteine formation Serine + homocysteine  cysteine + homoserine Alanineserine  dehydration and transamination Phosphotidyl serine Azaserine -anti cancer drug, cycloserine - antituberculous drug Choline Selenocysteine Part of protein

Component of protein:

Component of protein Serine forms active groups of many enzymes like trypsin and coagulation factors. So they are called serine proteases Phosphorylation and dephosphorylation of many enzymes occur at serine, threonine or tyrosine residues( eg . Glycogen phosphorylase )

Summary:

Summary Serine obtained from phosphoglycerate , Glycine and transamination It is catabolised to pyruvate , hydroxypyruvate or glucose Functions: One C, formation of cysteine and alanine , drugs, choline , selenocysteine , part of proteins Serine proteases and phosphorylation

References:

References Vasudevan

Marriage reception:

Marriage reception

Photo session:

Photo session

Honeymoon- ooty:

Honeymoon- ooty

With sathyaraj:

With sathyaraj

Nanu alias narayan:

Nanu alias narayan

PowerPoint Presentation:

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