lipid metabolism- FAS complex

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LIPID METABOLISM- Fatty acid synthase complex and Sources of Acetyl Coa and NADPH:

LIPID METABOLISM- Fatty acid synthase complex and Sources of Acetyl Coa and NADPH Dr. Hariharan , V Assistant professor, Department of Biochemistry, Karpagam Faculty of Medical Sciences and Research, Coimbatore. Free ppt available in www.authorstream.com/ search drhari

Fatty acid synthesis-introduction:

Fatty acid synthesis-introduction Fatty acid synthesis also called Linen’s Spiral Also called denovo synthesis of fatty acids Occurs in cytosol of many tissues It requires NADPH, ATP, Mn , Biotin, HCO3 Acetyl CoA is the substrate and Palmitate (16C) is the end product Free ppt available in www.authorstream.com/ search drhari

Malonyl CoA synthesis:

Malonyl CoA synthesis Acetyl CoA is Carboxylated (addition of CO 2 ) to Malonyl CoA by acetyl CoA carboxylase HCO 3 is taken up by Biotin to form Carboxy Biotin, which complexes with the enzyme. The CO 2 attaches with Acetyl CoA to form Malonyl CoA Free ppt available in www.authorstream.com/ search drhari

Fatty acid synthase:

Fatty acid synthase In bacteria Fatty acid synthesis is governed by many separate enzymes. In Humans FAS is multi enzyme polypeptide complex, which has Acyl Carrier Protein (ACP), which takes the part of CoA It contains Pantothenic acid in the form of 4-Phospho Pantetheine FAS contains 2 identical monomers which performs all the all seven enzyme actions of fatty acid synthesis Free ppt available in www.authorstream.com/ search drhari

Features of Fatty acid synthase complex:

Features of Fatty acid synthase complex Derived from a single gene Compartmentalization achieved easily, without the metabolites moving here and there. Synthesis of all enzymes in the complex is easily coordinated, since it is produced from a single gene Free ppt available in www.authorstream.com/ search drhari

FAS complex:

FAS complex Free ppt available in www.authorstream.com/ search drhari

Sources of acetyl Coa and NADPH:

Sources of acetyl Coa and NADPH Free ppt available in www.authorstream.com/ search drhari

Sources of NADPH:

Sources of NADPH The two reductase reactions in FA synthesis requires NADPH NADPH is derived from HMP shunt pathway Tissues where FA synthesis is active like- adipose tissue, liver, lactating mammary gland posess active HMP shunt pathway Both HMP shunt and FA synthesis occur in cytosol , so no transport required Other sources of NADPH- Malic enzyme and extramitochondrial ICD Free ppt available in www.authorstream.com/ search drhari

Sources of acetyl coA:

Sources of acetyl coA Acetyl CoA formed from Glucose in in mitochondria have to be transported to cytosol . Citrate formed from Acetyl CoA  transported to Cytosol using tricarboxylate transporter reforms Acetyl CoA + Oxaloacetate using CoA and ATP by ATP citrate lyase whose activity increased in well fed state The oxaloacetate becomes malate  Malate becomes Pyruvate by Amlic Enzyme liberating NADPH Free ppt available in www.authorstream.com/ search drhari

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References:

References Harper Free ppt available in www.authorstream.com/ search drhari

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