cancer immunotherapy

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I mmunotherapy B.Devadatha 123680029

What is immunotherapy?:

What is immunotherapy? Treatment that uses certain parts of the immune system to fight diseases such as cancer Stimulating your own immune system to work harder or smarter to attack cancer cells Giving you immune system components, such as man-made immune system proteins Dr William Coley used Coley's Toxins in the late 1800s as crude immunotherapy with some success. first therapeutic monoclonal antibodies rituximab ( Rituxan ) and trastuzumab (Herceptin) were approved during the late 1990s to treat lymphoma and breast cancer

Immune Response to Tumors:

Immune Response to Tumors

Types of immunotherapy:

Types of immunotherapy Passive immunotherapy: Adminstration of monoclonal antibodies which target either tumour-specific or over-expressed antigens. Active immunotherapies: Cytokines- IL-2 / IFNs / TNF α Cancer vaccines Cell-based therapies tumour-specific CTL tumour-derived APC DC priming

Monoclonal antibody therapy:

Monoclonal antibody therapy monoclonal antibodies that bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell . Naked mAbs : antibodies that work by themselves. boost a person’s immune response against cancer cells. blocking specific proteins that help cancer cells grow. Eg . Trastuzumab-HER2 Conjugated mAbs: are those joined to a chemotherapy drug, radioactive particle, or a toxin Radiolabelled: Ibritumomab tiuxetan and tositumomab –CD20Ag Chemolabeled : brentuximab vedotin - CD30 antigen Immunotoxins : denileukin diftitox

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Monoclonal antibodies for cancer. ADEPT, antibody directed enzyme pro drug therapy; ADCC, antibody dependent cell-mediated cytotoxicity; CDC, complement dependent cytotoxicity; MAb , monoclonal antibody; scFv single-chain Fv fragment

Cancer vaccines:

Cancer vaccines Tumor cell vaccines: made from actual cancer cells that have been removed during surgery . Antigen vaccines: These vaccines boost the immune system by using only one antigen rather than whole tumor cells Dendritic cell vaccines: special immune cells in the body that help the immune system recognize cancer cells DNA vaccines: Vectors can be given bits of DNA that code for protein antigens. When the vectors are then injected into the body, this DNA might be taken up by cells and can instruct them to make specific antigens

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Mechanism of action of Sipuleucel ‑T

Adoptive immunotherapy for cancer:

Adoptive immunotherapy for cancer vemurafenib

Dendritic Cell based Immunotherapy :

Dendritic Cell based Immunotherapy

cytokine based cancer therapy:

cytokine based cancer therapy

Other drugs that boost the immune system:

Other drugs that boost the immune system Thalidomide: treatment for multiple myeloma Lenalidomide : Newer drug , treatment for multiple myeloma Bacille Calmette-Guérin : treatment of superficial forms of bladder cancer Colorectal cancer Lung cancer Melanoma Medicinal mushrooms : Agaricus subrufescens   -anticancer properties


Reference Kantoff PW, Schuetz TJ, Blumenstein BA, et al. Overall survival analysis of a phase II randomized controlled trial of a Poxviral -based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol . 2010;28:1099-1105 . Recent Advances and Current Challenges inTumor Immunology and Immunotherapy Text books: The biology of Cancer:R.A Weinberg 2 nd ed Kuby Immunology 8 th ed Ivan roitt Essential Immunology 12 th ed

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