logging in or signing up cancer immunotherapy devadathadatha Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 140 Category: Entertainment License: All Rights Reserved Like it (0) Dislike it (0) Added: December 08, 2013 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript PowerPoint Presentation: I mmunotherapy B.Devadatha 123680029 What is immunotherapy?: What is immunotherapy? Treatment that uses certain parts of the immune system to fight diseases such as cancer Stimulating your own immune system to work harder or smarter to attack cancer cells Giving you immune system components, such as man-made immune system proteins Dr William Coley used Coley's Toxins in the late 1800s as crude immunotherapy with some success. first therapeutic monoclonal antibodies rituximab ( Rituxan ) and trastuzumab (Herceptin) were approved during the late 1990s to treat lymphoma and breast cancer Immune Response to Tumors: Immune Response to Tumors Types of immunotherapy: Types of immunotherapy Passive immunotherapy: Adminstration of monoclonal antibodies which target either tumour-specific or over-expressed antigens. Active immunotherapies: Cytokines- IL-2 / IFNs / TNF α Cancer vaccines Cell-based therapies tumour-specific CTL tumour-derived APC DC priming Monoclonal antibody therapy: Monoclonal antibody therapy monoclonal antibodies that bind only to cancer cell-specific antigens and induce an immunological response against the target cancer cell . Naked mAbs : antibodies that work by themselves. boost a person’s immune response against cancer cells. blocking specific proteins that help cancer cells grow. Eg . Trastuzumab-HER2 Conjugated mAbs: are those joined to a chemotherapy drug, radioactive particle, or a toxin Radiolabelled: Ibritumomab tiuxetan and tositumomab –CD20Ag Chemolabeled : brentuximab vedotin - CD30 antigen Immunotoxins : denileukin diftitox PowerPoint Presentation: Monoclonal antibodies for cancer. ADEPT, antibody directed enzyme pro drug therapy; ADCC, antibody dependent cell-mediated cytotoxicity; CDC, complement dependent cytotoxicity; MAb , monoclonal antibody; scFv single-chain Fv fragment Cancer vaccines: Cancer vaccines Tumor cell vaccines: made from actual cancer cells that have been removed during surgery . Antigen vaccines: These vaccines boost the immune system by using only one antigen rather than whole tumor cells Dendritic cell vaccines: special immune cells in the body that help the immune system recognize cancer cells DNA vaccines: Vectors can be given bits of DNA that code for protein antigens. When the vectors are then injected into the body, this DNA might be taken up by cells and can instruct them to make specific antigens PowerPoint Presentation: Mechanism of action of Sipuleucel ‑T Adoptive immunotherapy for cancer: Adoptive immunotherapy for cancer vemurafenib Dendritic Cell based Immunotherapy : Dendritic Cell based Immunotherapy cytokine based cancer therapy: cytokine based cancer therapy Other drugs that boost the immune system: Other drugs that boost the immune system Thalidomide: treatment for multiple myeloma Lenalidomide : Newer drug , treatment for multiple myeloma Bacille Calmette-Guérin : treatment of superficial forms of bladder cancer Colorectal cancer Lung cancer Melanoma Medicinal mushrooms : Agaricus subrufescens -anticancer properties Reference: Reference Kantoff PW, Schuetz TJ, Blumenstein BA, et al. Overall survival analysis of a phase II randomized controlled trial of a Poxviral -based PSA-targeted immunotherapy in metastatic castration-resistant prostate cancer. J Clin Oncol . 2010;28:1099-1105 . Recent Advances and Current Challenges inTumor Immunology and Immunotherapy Text books: The biology of Cancer:R.A Weinberg 2 nd ed Kuby Immunology 8 th ed Ivan roitt Essential Immunology 12 th ed PowerPoint Presentation: Thank u for your attention You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.