ANTI ULCER AGENT SCREENING

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PHARMACOLOGICAL SCREENING OF ANTI ULCER AGENT:

PHARMACOLOGICAL SCREENING OF ANTI ULCER AGENT DEEPAK JAIN DEPT.OF PHARMACOLOGY SHRI RAM INSTITUTE OF TECHNOLOGY,JBP

ANTI ULCER AGENT SCREENING PYLORUS LIGATION IN RAT :

ANTI ULCER AGENT SCREENING PYLORUS LIGATION IN RAT THE BASIS OF THIS MOBEL IN THAT ACCUMULATION OF UNBUFFERED GASTRIC JUICE OVER A CERTAIN LENGTH AT TIME LEADS TO PEPTIC ULCERATION IN RATS WHOSE PYLORUS HAS BEEN LIGATED

WISTER RAT:

WISTER RAT WT. 150-180 GM FASTED BEFORE 48 HRS BEFORE OPERATIVE.. GIVEN WATER AD LIBITUM. PREVENT CANNIBALIS AND COPROPHAGY,(ANIMAL ARE HOUSE SINGLY IN CAGE WITH RAISED BOTTOM OF WIDE WIRE MESH.)

ANASTHETIC RAT:

ANASTHETIC RAT -ETHER ANESTHESIA ARE USED. -ORALLY GIVEN.

ORALLY GIVEN ETHER ANASTHETIC:

ORALLY GIVEN ETHER ANASTHETIC

INCISION LOCATION:

INCISION LOCATION AFTER GIVEN ANAESTHESIA A ONE INCH MIDLINE ABDOMINAL-INCISION IS GIVEN BELOW THE XIPHOID PROCESS

STOMACH LIFTED AND CLOSED WITH SUTURES:

STOMACH LIFTED AND CLOSED WITH SUTURES INCISION PYLORUS LIFTED OUT LIGATED REPLACED ABDONAL WALL CLOSED WITH SUTURE STOMCH DIAGRAM

TEST COMPOUND ADMINISTERED:

TEST COMPOUND ADMINISTERED -TEST COMPOUND GIVEN ORALLY SUB-CUTANEOUSLY - - ANIMAL PLACED IN PLASTIC CYLINDER

TEST COMPOUND ADMINISTERED (SUB-CUTANEOUS):

TEST COMPOUND ADMINISTERED (SUB-CUTANEOUS)

ANIMAL PLACED IN PLASTIC CYLINDER:

ANIMAL PLACED IN PLASTIC CYLINDER

DISSECTION:

DISSECTION DISSECTION ANIMAL REMOVED FROM CONTAINER ANIMAL SACRIFICED STOMACH DISSECTED OUT AFTER 17-19 HRS PYLORIC LIGATION

STOMACH CONTENT DRAINED OUT:

STOMACH CONTENT DRAINED OUT STOMACH DISSECT OUT CONTENT OF STOMACH ARE DRAINED INTO GRADUATED CENTRIFUGE TUBE COLLECT IN A BEAKER

DETERMINATION OF ACIDITY OF STOMACH CONTENT:

DETERMINATION OF ACIDITY OF STOMACH CONTENT TITRATION ASSEMBLY CONTENT OF STOMACH DETERMINE ACIDITY BY HOW MUCH AMT..OF ALKALI CONSUPT BY ACID TITRATION BY 0.1 N,NAOH

OBSERVED SEVERITY OF ULCER:

OBSERVED SEVERITY OF ULCER THE STOMACH OPENED ALONG ITS GREATER CURVATURE PINNED ON A CORK PLATE INNER SURFACE EXAMINED WITH BIOCULAR MICROSCOPE MICROSCOPE

Other method of screening of antiulcer drug:

Other method of screening of antiulcer drug 1-Stress ulcer models -restraint-induced ulcer -cold water immersion-induced ulcer 2-histamine-induced gastric ulcer 3-ethanol-induced mucosal damage

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