Vi song tinh chat dac trung tong hop va ung dung cac loai vi song

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Vi sóng (microwave), tính chất, đặc trưng, tổng hợp và ứng dụng các loại vi sóng

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1 MICROWAVE Instructor: Assoc.Prof.Dr . Phan Thanh Son Nam Students: Nguyen Quoc Khuong Anh 13053071 Lê Hà Việt Luân 13053072 Mang Tấn Phong 13053073 Trần Phạm Thanh Thảo 12144421

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2 INTRODUCTION 1 APPLICATIONS 2 CONCLUSIONS 3 CONTENT

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3 Electro Magnetic Spectrum Introduction Microwaves are electromagnetic waves whose frequencies range from about 300 MHz – 300 GHz wavelengths in air ranging from 100 cm – 1 mm.

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DIPOLE ROTATION:

DIPOLE ROTATION 6

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7 IONIC CONDUCTION

INTERACTION OF MATERIALS WITH MICROWAVES:

INTERACTION OF MATERIALS WITH MICROWAVES 8

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14 Publications

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15 APPLICATIONS 1 Microwave for Synthesis 2 Dry media reaction 3 Microwave for Extractions APPLICATION

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16 MICROWAVE FOR SYNTHESIS

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18 Introduction Benzimidazole and their chalcone derivatives play a vital role in pharmaceutical research and exhibit various pharmacological activities like antimicrobial , analgesic, anti-inflammatory, anticancer activity . Both conventional and microwave irradiated synthesis of chalcone has been carried out to compare their yield and reaction time. Method Microwave and conventional method Determining melting points TLC IR NMR

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22 Introduction Schiff bases are used as pigments and dyes, catalysts , intermediates in organic synthesis and as polymer stabilizers. Schiff bases have also been shown to exhibit a broad range of biological activities, including antifungal, antibacterial, antimalarial, antitubercular , antiviral, antiproliferative , anti-inflammatory and antipyretic properties Both conventional and microwave irradiated synthesis of Schiff bases has been carried out to compare their yield and reaction time. Method Microwave and conventional method Determining melting points TLC IR NMR

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26 Introduction Pyrazoline nucleus shows various biological and pharmacological activities such as antimicrobial, antiinflammatory , antitumor, anticonvulsant, antiviral, diuretic, antidiabetic , Analgesic, and anticancer. Both conventional and microwave irradiated synthesis of some new pyrazoline derivatives has been carried out to compare their yield and reaction time . Invitro antimicrobial study Method Microwave and conventional method Determining melting points TLC IR, MS NMR Invitro antimicrobial study

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32 DRY MEDIA REACTION

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34 Introduction The chromene ring moiety has been identified as one of the privileged scaffolds for drug discovery due to its broad spectrum of biological activity including antiviral, anti-tumor, anti-bacterial/antimicrobial, fungicidal, antioxidative , insecticidal agents, and activator of potassium channels effects. U sing a solvent-free methodology for the synthesis of 2-hydroxy-2- ( trifluoromethyl )-2H-chromenes from salicylaldehydes and ethyl trifluoroacetoacetate under solvent-free conditions in the presence of silica-immobilized L- proline (L- proline /SiO2). Method Microwave and conventional method Determining melting points TLC IR, MS NMR X-ray diffraction

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41 Introduction Chalcones and their derivatives have attracted increasing attention due to numerous biological and pharmacological applications such as antimalarial, anticancer, antiprotozoal, anti-inflammatory, antibacterial, antifilarial , antifungal, antimicrobial, larvicidal , anticonvulsant, antioxidant activities. imidazole derivatives have been reported a diverse biological activities such as antimicrobial, antitumor, antifungal, anticancer, antiviral activities. A solvent-free synthesis of 1-{2,4-dihydroxy-5-[3-imidazol-1-yl-3-aryl-propionyl]-3-aryl-propenones under microwave irradiation using Micheal addition of chalcones with imidazoles in the presence of glacial acetic acid as catalyst. antibacterial activity study Method Microwave and conventional method Determining melting points, TLC, IR, NMR antibacterial activity study

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45 Introduction The efficient synthesis of amides is important because of their wide range of applications in academia and industry specially as intermediates in organic synthesis or peptide and protein synthesis. Microwave-enhanced solvent free synthesis of the N- alkylbenzamides carried out in the presence of various heterogenous catalysts. Optimizing reaction conditions and studying various ways of catalytic activation of reactants. Method Microwave method Determining melting points TLC IR NMR

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49 MICROWAVE FOR EXTRACTIONS

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51 Dwarfed Cinnamomum Camphora Var . Linaolifera Fujita (D-CCLF) Leaves and Twigs. MAHD is proposed to perform for the extraction of essential oils from D-CCLF leaves and twigs and the results of extraction time, extraction yield, chemical composition , quality of the essential oil and operation cost are compared with those of traditional HD. linalool INTRODUCTION

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52 Method Microwave-assisted Hydrodistillation Traditional Hydrodistillation GC-MS SEM

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53 RESULTS 37,5 1,73 1,71 Step1 : the heating phase from room temperature to boiling temperature Step 2 : extracted essential oils at the surface of vegetable particles Step 3 : the internal diffusion of the essential oil Step 4 : a horizontal line which marked the end of the extraction process. 79% 62%

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56 Essential oil of leaf Essential oil of twig MAHD HD MAHD HD Extraction time (min) 45 150 90 90 Yield (%) 1,73 1,71 0,35 0,33 Total oxygenated compounds 86,99 85,24 - - Energy (kWh) 0,36 1,15

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57 (a) (b) (c) Scanning electron micrographs of leaves: (a) untreated, (b) after hydro distillation for 150 min and (c) after microwave-assisted hydro distillation for 45 min

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58 CONCLUSION MAHD offer important advantages over traditional HD for the extraction of leaf essential oil, but it has no obvious advantage in extracting essential oil of twig. A similar extraction yield of leaf essential oils is achieved at shorter extraction time (37.5 min for MAHD vs. 120 min for HD) and lower energy consumption (0.21 kWh/g of essential oil for MAHD vs. 0.67 kWh/g of essential oil for HD ). Microwaves seems to cause a higher extraction efficiency of rupture for the glandular cells than in conventional HD.

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60 Myrtus communis L. Leaves many biological properties: hypoglycemic, antimicrobial, analgesic , antioxidant etc . Comparative Study of Essential Oils Extracted from Algerian Myrtus communis L. Leaves Using solvent-free -microwave-extraction and conventional Hydrodistillation INTRODUCTION

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61 METHOD

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63 RESULTS

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68 CONCLUSION Solvent Free Microwave extraction SFME was found to be highly effective enabling a considerable reduction in extraction time (30 min against 180 min), providing an essential oil with a chemical composition enriched in oxygenated compounds but with yields similar to those of steam distillations. SFME required only the initial water content of the raw material. Thus, it consumed much less energy than hydrodistillation . SFME is a good alternative to other extraction techniques.

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69 CONCLUSION

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4/12 green principles may be adapted by using microwave 70

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71 REFERENCES 1. Hayes , B.L.  Microwave Synthesis: Chemistry at the Speed of Light;  CEM Publishing: Matthews, NC, 2002 . 2. Bharat Parashar , Sudhir Bhardwaj , Sharda Sharma, G. D. Gupta, V. K. Sharma and P . B. Punjabi. Comparative Conventional and Microwave assisted synthesis of some pyrazoline derivatives and their antimicrobial activity . J . Chem. Pharm. Res ., 2(3): 33-42, 2010 3. Sahoo Biswa Mohan, Behera T.P., Ravi Kumar B.V.V. Microwave Irradiation Versus Conventional Method: Synthesis of Benzimidazolyl Chalcone Derivatives. International Journal of ChemTech Research Vol.2, No.3, pp 1634-1637, 2010 4 . Baya Berka-Zougali , Mohamed-Amine Ferhat , Aicha Hassani , Farid Chemat and Karim S. Allaf . Comparative Study of Essential Oils Extracted from Algerian Myrtus communis L. Leaves Using Microwaves and Hydrodistillation . Int. J. Mol. Sci 13 , 4673-4695, 2012 5. Cuilian Xu , Guoyu Yang, Caixia Wang, Sufang Fan, Lixia Xie and Ya Gao . An Efficient Solvent-Free Synthesis of 2-Hydroxy-2-( trifluoromethyl )-2H-chromenes Using Silica-Immobilized L- Proline . Molecules ,18 , 11964-11977, 2013 6 . Enamul Hassain S, Chaluvaraju KC, Niranjan MS, Zaranappa , Santhosh C. Studies On Microwave Assisted Synthesis Of Some Schiff Bases. J. Pharm.4 (11 ), 2013 . 7. K . Aravind , Arram Ganesh and D. Ashok. Efficient solvent-free microwave assisted organic synthesis of 1-{2,4-dihydroxy-5-[3-imidazol-1-yl-3-aryl-propionyl]}-3-aryl-propenone and their antibacterial activity . Journal of Chemical and Pharmaceutical Research, 5(6 ): 34-39, 2013 8 . Linsheng Wei, Yafang Zhang and Boquan Jiang. Comparison of Microwave-assisted Hydrodistillation with the Traditional Hydrodistillation Method in the Extraction of Essential Oils from Dwarfed Cinnamomum Camphora var. Linaolifera Fujita Leaves and Twigs . Advance Journal of Food Science and Technology 5(11): 1436-1442, 2013 .

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72 THANK YOU!

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