Neuro Challenge 2 minute pitch_ Final

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Hemisphere Pharmaceuticals

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Alzheimer’s Disease (AD) Fact Sheet 2014, www.alz.org Today, over 5 million Americans are living with AD. By 2050, that number is expected to triple . In 2014, the direct costs to American society of caring for those with AD will total an estimated $214 billion, including $150 billion in costs to Medicare and Medicaid. AD is the 6 th leading cause of death in the United States AD is the only cause of death (among the top 10) without any way to prevent, cure or slow progression Deaths from AD increased 68% between 2000 and 2010

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Product Developed by NIH researchers (US Government is patent assignee) Novel cyclin dependent kinase 5 (Cdk5) inhibitory peptide fragment, TFP5, to treat Alzheimer’s disease (AD). S hown to ameliorate symptoms in a double transgenic mouse (APP/PS1) AD model without any evidence of toxicity. TPF5 is derived from a natural product, P5, but has been modified to cross the BBB. ( Zheng et al., 2007)

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Management Team Diverse backgrounds Relevant expertise Strong advisory board with extensive experience in biotech start-up

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Development in Louisiana

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R&D Pathway

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Q1 2016 Q2 2016 Q3 2016 Q4 2016 Q1 2017 Q2 2017 Q3 2017 Q4 2017 Q1 2018 Q2 2018 Q3 2018 Q4 2018 Lab Space/Materials $750,000 Legal $150,000 Travel/Administrative $10,000 $30,000 Manufacturing $146,000 Pre-clinical studies $150,000 Phase 1 trial $450,000 IT/Data Management $75,000 Company Next Steps Timeline

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