Oxygenation Therapy : Oxygenation Therapy Slide 2: A FUNDAMENTAL STRATEGY to
OPTIMIZE HEALTH and
PREVENT DISEASE ENERGY PRODUCTION : ENERGY PRODUCTION Slide 4: The amount of energy production a person is capable of is the major factor influencing the health peaks and troughs of human life Slide 5: The reduction of physical and mental abilities is a main characteristic of extreme old age Slide 6: A main characteristic of illness is that the person minimizes their energy requirements by a reduction in activity both physically and mentally Slide 7: All events, mechanisms and processes that weaken, strengthen or lastingly increase energy production are of fundamental importance in health and disease. Slide 8: Energy is generated mainly as chemical energy in the form of energy rich phosphate bonds; particularly ATP (Adenosine TriPhosphate) Slide 9: Under normal conditions the production of ATP is not limited by the intake of food but by OXYGEN transport to the tissues of the body. Slide 10: 10/19/10 Slide 11: “OXYGEN IS THE GIVER OF LIFE”
~ Otto Warburg
Oxygen is the prerequisite for cell differentiation during embryologic development, growth and maturation oxygen is essential for the maintenance of life its deficiency leads to complaints, suffering, disease and death. Slide 12: Oxygen Deficiency
Can be a result of one or more of the following factors:
Reduced oxygen transport to the tissues/cells
Reduced oxygen utilization of the tissues/cells
Increased oxygen requirements of the tissue/cells. Slide 13: IMPROVING OXYGENATION
IS THE GOAL OF
OXYGEN MULTISTEP THERAPY Aging : Aging The one thing all aspects of the aging process have in common is the progressive reduction in the ability to make energy at the cellular level.
This is a function of wear and tear Slide 16: What the hell is wear and tear?
Why is it happening to us? Slide 17: The energy of our lives is produced by our cells
The most efficient energy production occurs in small organelles called mitochondria via the citric acid cycle
On average each cell has between 1,000-2,000 mitochondria.
There is a back up pathway which is less efficient and creates acid in the process of producing energy; the Pentose Monophoshphate Shunt Pathway Slide 18: The efficiency of mitochondrial energy production can be reduced by toxins, inflammation, infections, and nutritional insufficiency.
When insults are acute and self limiting we and our mitochondria usually recover.
When insults are too great or prolonged there is a gradual loss of mitochondrial efficiency. Slide 19: We experience fatigue when we do not produce enough energy at the cellular level.
Our metabolic rate slows down and we gain weight or can not lose weight when we do not produce enough energy at the cellular level.
Our cells age and we age in relationship to the gradual decline in the efficiency of energy production. Slide 20: Energy production is fundamental to all aspects of cellular and organ function including:
Motor Function Slide 21: A Paradigm for Understanding Health
How do we describe health?
Not the absence of symptoms
Not the absence of disease
Not the absence of abnormal tests
Health is the resiliency of our energy producing processes Slide 22: With a loss in efficiency of mitochondrial energy production:
We burn less fat and more glucose
We make more of our energy from cellular pathways outside the mitochondria (anaerobic)
We make less energy Slide 23: Fatigue, Degenerative disease, Obesity and aging are preceded by a decrease in oxidation potential and mitochondrial energy production which occurs long before chronic disease and aging
This decrease in efficiency of energy production results from two commonly occurring states:
Decreased oxidation of fat, which leads to and is compounded by a second state
Decreased mitochondrial efficiency Slide 25: 10/19/10 Max
ATP Glucose Glucose Glucose Anaerobic Anaerobic Anaerobic Healthy Mito-Decay
Disease The Stages Of reduction in Mitochondrial Efficiency Fat Fat Fat Fat Glucose Anaerobic Max
“Healthy for your age” Max
Fat Slide 26: Pre-Mitochondrial
1. Decreased lipolysis.
2. Elevated Blood Sugar
3. Poor Circulation
3. Reduced Oxygenation
4. B Vitamin Deficiency
5. Inflammation Mitochondrial
Mitochondrial decay Causes of Decreased Mitochondrial Efficiency Testing : Testing Partial Pressure of Venous Oxygen
This measures the amount of oxygen
utilized by the cells Slide 29: Factors effecting PaO2 adversely
Cardiac Diseases Slide 31: Factors effecting vO2 adversely
Acid Base Balance
Surgery/Trauma Slide 32: Testing Interpretation
PaO2 is around 90-100 mmHg in healthy people under 50.
It typically declines by 5-10 mmHg in each decade.
It is not uncommon to see it be 65-75 mmHg in people in their late seventies
It can also be reduced in younger people who are ill. Slide 33: Testing Interpretation
vO2 is 25-35 mmHg in healthy people
The relationship to PaO2 is important
Optimally, the difference (n) between PaO2 and vO2 should be 60 mmHg or more
It can be lower than that for all the reasons noted previously
Lower levels may be acute and transient or chronic Oxygen Multi-step Therapy : Oxygen Multi-step Therapy Step 1: Increase O2 utilization in tissues
By means of drugs and or supplements
Taken 30 minutes before starting Step 2 Oxygen Multi-step Therapy : Oxygen Multi-step Therapy DRUGS: DYPYRIMADOL 75 mgs
VITAMIN B1 25-50 mgs
Magnesium Orotate 100 mgs
L Arginine 1000 mgs
Quercetin Activated 1000 mgs
Amino Max 3 capsules Oxygen Multi-step Therapy : Oxygen Multi-step Therapy STEP 2: INCREASE THE PARTIAL PRESSURE OF OXYGEN IN THE ALVEOLAR SPACE/LUNGS WITH SUPPLEMENTAL OXYGEN
WE TYPICALLY USE A REBREATHER MASK TO SUPPLY 100% OXYGEN.
THE AIR WE BREATHE HAS 20% OXYGEN Oxygen Multi-step Therapy : Oxygen Multi-step Therapy STEP 3: INCREASE BLOOD FLOW THROUGH EXERCISE AT A THERAPEUTIC HEART RATE. Oxygen Multi-step Therapy : Oxygen Multi-step Therapy A Therapeutic Heart Rate Range, (THR), is best determined by CardioPulmonary Stress Testing.
The goal is to be in a heart range that utilizes mitochondrial, (aerobic), metabolism for energy production.
Anaerobic Metabolism produces too many free radicals and may be injurious to people whose health is not optimal. Oxygen Multi-step Therapy : Oxygen Multi-step Therapy Length of session
Typically 15-30 minutes
Frequency in order to achieve benefit
3 times per week. Oxygen Multi-step Therapy : Oxygen Multi-step Therapy THERAPEUTIC PROCESS
TIME TO BENEFIT VARIES WITH THE AGE AND HEALTH OF THE INDIVIDUAL
TYPICALLY 6 TO 12 WEEKS WILL PRODUCE A GOOD RESULT.
We typically repeat the oxygenation study in 4-8 weeks. Oxygen Multi-step Therapy : Oxygen Multi-step Therapy HOW LONG WILL THE BENEFIT LAST?
The benefit will last from months to a year depending on the background health of the individual, intercurrent illness or injury, appropriate lifestyle changes and adherence to a supplementation regimen Adjunctive Therapy : Adjunctive Therapy OMST may be beneficial in a variety of health problems.
Cardiovascular diseases: Hypertension, Coronary Artery Disease, Congestive Heart Failure, Peripheral Vascular Disease
Pulmonary Diseases: There is a normative, age related decline in pulmonary function. OMST is helpful in slowing this decline. It will not reverse advanced emphysema/COPD, however, it will be useful in improving function and slowing progression NEUROLOGIC DISEASE : NEUROLOGIC DISEASE MILD COGNITIVE IMPAIRMENT WILL RESPOND TO OMST IF THE TESTING SHOWS REDUCED OXYGEN DELIVERY TO THE PERIPHERAL TISSUES.
WILL IT PREVENT PROGRESSION TO ALZHEIMERS? I DO NOT KNOW NEUROLOGIC DISEASE : NEUROLOGIC DISEASE OMST WILL HELP PATIENTS WHO HAVE HAD A STROKE.
THERE IS TYPICALLY A ‘PENUMBRA OF ISCHEMIA’ AROUND THE DEAD TISSUE.
IMPROVEMENT IN OXYGENATION WILL AWAKEN THE SHOCKED CELLS AND RESULT IN IMPROVED FUNCTION. NEOPLASTIC DISEASE : NEOPLASTIC DISEASE CANCER THRIVES IN CONDITIONS OF POOR OXYGENATION
OMST IMPROVES OXYGENTATION.
THEORETICALLY IT SHOULD HELP PREVENT CANCER DEVELOPMENT NEOPLASTIC DISEASE : NEOPLASTIC DISEASE OMST WAS INVESTIGATED AS AN ADJUNCTIVE THERAPY FOR CANCER IN GERMANY IN THE 1960’s
THE RESULTS WERE PROMISING BUT NOT CONCLUSIVE, ESPECIALLY BY TODAYS STANDARDS. NEOPLASTIC DISEASE : NEOPLASTIC DISEASE OMST WILL HELP MINIMIZE THE SIDE EFFECTS OF CONVENTIONAL CANCER THERAPIES: SURGERY, CHEMOTHERAPY, AND RADIATION
THIS IS NOT SPECULATION ! HEALTHY AGING : HEALTHY AGING OMST IS A COST EFFECTIVE TOOL IN OPTIMIZING HEALTH, SLOWING NORMATIVE AGING, AND MAINTAINING FUNCTIONAL CAPACITY Slide 52: Oxygen Multi Step Therapy
Supersaturates the blood and tissue with oxygen
Improves aerobic capacity more quickly than regular exercise
Particularly useful for people who can not exercise vigorously because of age related reductions in conditioning or chronic illness Slide 53: Oxygen Multi Step Therapy
It does not require excessive effort and thus does not produce post exercise fatigue common to individuals with chronic fatigue, obesity and aging. Slide 54: Oxygen Step Therapy
It requires 15 minutes on an exercise bicycle while breathing 100% oxygen
Best done 2-3 times per week to achieve maximum benefit.
30 years of research in Germany show it to be safe and effective.
Once improvement in oxygen levels occurs it is maintained until the individual experiences new stress or illness Slide 55: You Are Not Old Until Your Dreams are Replaced by Your Regrets