2009StanfordE25 Ramon Qiu and Alex Dao

Leukemia : 

Leukemia Ramon Qiu Alex Dao 2009StanfordE25

Asian American Donor Program : 

Asian American Donor Program Modest beginnings in 1989 123 Asian donors in national registry Encourage typing of minorities Launched Latino Outreach Program in 2008

?F? : 

?F? Lambda Phi Epsilon is the first and only international Asian American interest fraternity Our National Philanthropy: Raise awareness for Leukemia

AADP : 

AADP

Slide 6: 

What is Leukemia?

Slide 7: 

From Lecture: Leukemia is a cancer of a white blood cell. For example, B cell leukemia is when B cells proliferate indefinitely.

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Four Types of Leukemia: Acute Myelogenous Leukemia (AML) Acute Lymphocytic Leukemia (ALL) Chronic Myelogemous Leukemia (CML) Chronic Lymphocytic Leukemia (CLL)

Slide 9: 

Four Types of Leukemia: Acute Myelogenous Leukemia (AML) – Most common form Acute Lymphocytic Leukemia (ALL) Chronic Myelogemous Leukemia (CML) Chronic Lymphocytic Leukemia (CLL)

Slide 10: 

Four Types of Leukemia: Acute Myelogenous Leukemia (AML) – Most common form Acute Lymphocytic Leukemia (ALL) – Most common in children Chronic Myelogemous Leukemia (CML) Chronic Lymphocytic Leukemia (CLL)

Slide 11: 

Four Types of Leukemia: Acute Myelogenous Leukemia (AML) – Most common form Acute Lymphocytic Leukemia (ALL) – Most common in children Chronic Myelogemous Leukemia (CML) – More common in adults Chronic Lymphocytic Leukemia (CLL)

Slide 12: 

Four Types of Leukemia: Acute Myelogenous Leukemia (AML) – Most common form Acute Lymphocytic Leukemia (ALL) – Most common in children Chronic Myelogemous Leukemia (CML) – More common in adults Chronic Lymphocytic Leukemia (CLL) – Only occurs in adults

Slide 13: 

Acute Myelogenous Leukemia (AML)

Slide 14: 

Most common form (occurs in adults and children) Most dangerous (fastest acting)

Slide 16: 

Begins with 1 cell

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Begins with 1 cell Cell multiplies into trillions of copies

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Begins with 1 cell Cell multiplies into trillions of copies Red blood cells under produced (anemia)

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Begins with 1 cell Cell multiplies into trillions of copies Red blood cells under produced (anemia) White blood cells under produced (immune system failure)

Slide 20: 

Begins with 1 cell Cell multiplies into trillions of copies Red blood cells under produced (anemia) White blood cells under produced (immune system failure) Platelets under produced (stops blood clotting)

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http://images.the-scientist.com/content/images/articles/23273/ecology_infoL.jpg

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Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc… Expression of these genes inhibits cell differentiation Forces cells to copy the Leukemia cell.

Slide 23: 

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc… Event 2: Anti-senescence Senescence is a mechanism that forces cells to stop dividing Leukemia cells disable this mechanism

Slide 24: 

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc… Event 2: Anti-senescence Event 3: Anti-apoptotic Apoptosis is a mechanism where a cell destroys itself Apoptosis is necessary when a cell is damaged or infected Leukemia cells disable this mechanism

Slide 25: 

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc… Event 2: Anti-senescence Event 3: Anti-apoptotic Event 4: Apoptosis receptor pathway silenced Apoptosis can also be triggered from surrounding tissue Same idea as Event 3

Slide 26: 

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc… Event 2: Anti-senescence Event 3: Anti-apoptotic Event 4: Apoptosis receptor pathway silenced Event 5: Evade immune cells Events 1-4

Slide 27: 

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc… Event 2: Anti-senescence Event 3: Anti-apoptotic Event 4: Apoptosis receptor pathway silenced Event 5: Evade immune cells Event 6: Activate and over express self renewal path genes

Slide 28: 

http://images.the-scientist.com/content/images/articles/23273/ecology_infoL.jpg

Slide 29: 

Treating Leukemia

Slide 30: 

Induction Therapy Consolidation Therapy

Slide 31: 

Induction Therapy

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Induction Therapy Chemotherapy

Slide 33: 

Induction Therapy Chemotherapy Kill as many AML cells as possible

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Induction Therapy Chemotherapy Kill as many AML cells as possible Achieve remission

Slide 35: 

Induction Therapy Chemotherapy Kill as many AML cells as possible Achieve remission 3-4 weeks

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Induction Therapy Chemotherapy Kill as many AML cells as possible Achieve remission 3-4 weeks Consolidation Therapy

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Induction Therapy Chemotherapy Kill as many AML cells as possible Achieve remission 3-4 weeks Consolidation Therapy More chemotherapy

Slide 38: 

Induction Therapy Chemotherapy Kill as many AML cells as possible Achieve remission 3-4 weeks Consolidation Therapy More chemotherapy Stem cell transplant

Slide 39: 

Induction Therapy Chemotherapy Kill as many AML cells as possible Achieve remission 3-4 weeks Consolidation Therapy More chemotherapy Stem cell transplant Get blood cell count back to normal

Slide 40: 

Induction Therapy Chemotherapy Kill as many AML cells as possible Achieve remission 3-4 weeks Consolidation Therapy More chemotherapy Stem cell transplant Get blood cell count back to normal Take immunosuppressant drugs

Slide 41: 

Myths and Facts

Slide 42: 

Myth: Donating Bone Marrow is Painful

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Myth: Donating Bone Marrow is Painful Fact: Anesthesia is always used Donors feel no pain or needle injections Donors feel a little pain in the lower back a few days after the procedure

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Myth: Donating Bone Marrow involves surgery

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Myth: Donating Bone Marrow involves surgery Fact: Majority of donations do not involve surgery Usually taking peripheral blood stem cells is enough

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Myth: Pieces of Bone are removed from the donor

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Myth: Pieces of Bone are removed from the donor Fact: Majority of donations involve taking only blood In marrow donation, only marrow is taken from inside bone, not the bone itself

Slide 48: 

Myth: Donating Bone Marrow is dangerous

Slide 49: 

Myth: Donating Bone Marrow is dangerous Fact: The procedure is relatively safe and there are rarely any long term side effects from donating All the donated marrow is replenished within 1 month

Slide 50: 

Myth: Bone Marrow donation involves a lengthy recovery

Slide 51: 

Myth: Bone Marrow donation involves a lengthy recovery Fact: Most donors take the drug filgrastim and experience minor symptoms that disappear 2 days after donating Marrow donors will feel tired and some soreness for less than a week, with all symptoms disappearing after 2-3 weeks

Nick Glasgow : 

Nick Glasgow

Nick Glasgow : 

Nick Glasgow 28 years old Diagnosed with AML in March 2009 75% Caucasian and 25% Japanese Desperately needs your HELP

What you can do NOW : 

What you can do NOW Where do I register?You can register in one of three ways:1.) Visit a local drive near you. 2.) Call or e-mail AADP for a HOME-TEST KIT if you cannot attend a drive. 3.) Visit the AADP office in Alameda or a local donor center in Stanford, Oakland, or Sacramento, to register in person. Appointments must be made beforehand. 4.) Encourage family/friends/dormmates/fraternity brothers/sorority sisters to get their bone marrow typed!

Slide 55: 

Thank you for registering. SAVE A LIFE TODAY!