Slide 2:
Myeloma Cells Plasma Cells
Slide 3:
Hematopoietic stem cell Common lymphoid progenitor Pro-B cell Pre-B cell Immature B cell Tumor Cell Plasma Cell
Slide 4:
Deletions Translocations Mutations Radiation Viral i nfection Exposure to toxic chemicals Plasma Cell
Slide 5:
Stromal Cells
Slide 6:
Osteoblast Osteoclast
Slide 7:
Myeloma paraprotein (M-Protein) Bence Jones protein M-protein spike
Slide 8:
Causes Direct damage to nerve Compression of n erves caused by bone damage Accumulation of protein near nerves Autoimmune reaction Symptoms Altered skin sensations Muscle weakness Autonomic dysfunctions Peripheral Neuropathy
Slide 10:
Major cause of mortality Immunodeficiencies Lung Sinuses Urinary tract
Slide 11:
Monoclonal Gammopathy of Undetermined Significance M-GUS Presence of M-protein Smoldering Multiple Myeloma sMM >10% cells in marrow are tumor cells Multiple M yeloma MM alcium elevation enal dysfunction nemia one disease C R A B
Slide 12:
Bone damage Peripheral neuropathy Renal impairment Immunodeficiencies