Nucleic Acids

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Biochemistry of DNA and RNA with full illustration has been incorporated in the power point presentation.

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Slide 1: 

Biochemistry of Nucleic acids Dr. S.K. Chile

Slide 2: 

Ribose nucleic acid RNA Deoxy ribose nucleic acid DNA

Structure of molecules : 

Structure of molecules Primary structure Secondary structure Tertiary structure Quaternary structure

Primary structure : 

Primary structure Nitrogen base Sugars Phosphate

Slide 5: 

Nitrogen Base Purine Pyrimidine

Slide 6: 

Purine Pyrimidine

Slide 7: 

Adenine 6, Aminopurine Guanine 2,Amino 6, Ketopurine

Slide 8: 

Guanine 2,Amino 6, hydroxypurine Guanine 2,Amino 6, Ketopurine Tautomerism

Slide 9: 

Uracil Thymine or 5,Methyl uracil Cytosine 2,6 Keto Pyrimidine 2,6 Keto 5,Methyl Pyrimidine 2, Keto 6 Amino Pyrimidine

Slide 10: 

Uracil

Slide 11: 

Thymine

Slide 12: 

Cytosine

Slide 13: 

Sugars Ribose Deoxy ribose

Slide 14: 

D-RIBOSE 2-DEOXYRIBOSE

Secondary structure : 

Secondary structure Sugar +Nitrogen base= Nucleoside Sugar +Nitrogen base+ Phosphate= Nucleotide

Slide 17: 

Bond between sugar and nitrogen base is N-Glycosidic bond Compare N-Glycosidic bond and O-Glycosidic bond What are Phosphoester bond and Di-phosphoester bond ?

Slide 18: 

+ Nucleoside Ribose

Slide 19: 

Nucleotide Ribose

Slide 20: 

Nucleoside Ribose

Slide 21: 

Nucleotide Ribose

Slide 22: 

+ Nucleoside Deoxyribose

Slide 23: 

Nucleotide Deoxyribose

Slide 24: 

Nucleoside Deoxyribose

Slide 25: 

Nucleotide Deoxyribose

Slide 26: 

Nucleotide Ribose

Slide 27: 

Nucleotide Deoxyribose

Slide 28: 

OH I O=P-OH I OH Nucleotide Ribose

Slide 29: 

OH I O=P-OH I OH Nucleotide Deoxyribose

Nucleosides and Nucleotides : 

Nucleosides and Nucleotides Adenine Adenosine 2’-Adenylic acid Adenisine-2’-phosphate 2’-Adenosine monophosphate 3’-AMP 5’-AMP 2’-AMP

Nucleosides and Nucleotides : 

Nucleosides and Nucleotides Uracil Uridine 2’-Uridylic acid Uridine-2’-phosphate 2’-Uridine monophosphate 3’-UMP 5’-UMP 2’-UMP

Nucleosides and Nucleotides : 

Nucleosides and Nucleotides Cytosine Cytidine 2’-Cytidylic acid Cytidine-2’-phosphate 2’-Cytidine monophosphate 3’-CMP 5’-CMP 2’-CMP

Nucleosides and Nucleotides : 

Nucleosides and Nucleotides Guanine Guanosine 2’-Guanylic acid Guanosine-2’-phosphate 2’-Guanosine monophosphate 3’-GMP 5’-GMP 2’-GMP

Deoxyribonucleotides series : 

Deoxyribonucleotides series Deoxyadenine Deoxyadenosine 2’-Deoxyadenylic acid Deoxyadenisine-2’-phosphate 2’-Deoxyadenosine monophosphate 3’-dAMP 5’-dAMP 2’-dAMP

Deoxyribonucleotides series : 

Deoxyribonucleotides series Deoxycytidine 3’-Deoxycytidylic acid 5’-Deoxycytidylic acid 5’-dCDP 5’-dCTP 3’-dCMP 5’-dCMP

Deoxyribonucleotides series : 

Deoxyribonucleotides series Thymidine 3’-Thymidylic acid 5’- Thymidylic acid 5’-dTDP 5’-dTTP 3’-dTMP 5’-dTMP

Deoxyribonucleotides series : 

Deoxyribonucleotides series Deoxyguanosine 3’-Deoxyguanylic acid 5’- Deoxyguanylic acid 5’-dGDP 5’-dGTP 3’-dGMP 5’-dGMP

Tertiary structure : 

Tertiary structure Formation of polynucleotide chain by the polymerization of nucleotides of different types.

Slide 39: 

5’ 3’ 3’ 5’

Quaternary structure : 

Quaternary structure Pairing two of polynucleotide chains by the formation of bonds between the base pairs and helical coiling.

Slide 41: 

5’ 3’ 3’ 5’

Slide 44: 

Bond distances and angles of Cytosine To chain

Slide 49: 

Thanks Dr. S.K. Chile