solid mixers

Views:
 
     
 

Presentation Description

No description available.

Comments

By: shethvijay44 (20 month(s) ago)

respected Madam your ppt is very helpful for me. if possible kindly mail me on shethvijay44@gmail.com

By: shafayat06 (20 month(s) ago)

Hi, I have viewed your presentation. Now I need it. Would you please send me the presentation. My mail ID is mamun07ndc@gmail.com

By: manojsuva (24 month(s) ago)

respected m'am..i have read one of your ppt solid mixtures. if possible than mail me at manojsuva_0211@yahoo.co.in thankyou

Presentation Transcript

PowerPoint Presentation:

A SEMINAR ON MIXER ( AS PER SCHEDULE M) PREPARED BY : GUIDED BY: ANKIT PATEL MRS. CHETNA MODI M.PHARM SEM-1 M.PHARM DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY SHREE KRISHNA INSTITUTE OF PHARMACY, SHANKHALPUR, BECHARAJI. solid mixers

PowerPoint Presentation:

What is mixing? Mixing is an operation in which two or more than two components in a separate or roughly mixed conditions are treated so that each particles lies as nearly as possible in contact with a particle of each of the other ingredients. Types of mixtures Positive mixtures Negative mixtures Neutral mixtures solid mixers

PowerPoint Presentation:

Positive mixtures Formed from materials such as gases or miscible liquids. Irreversible mixing. Take place by diffusion process. It also take place without any need of energy. E.g. sugar in water, Alcohol in water Such materials do not produce any problems in mixing. solid mixers

PowerPoint Presentation:

Negative mixtures Require the energy for their formulation. Mixtures are more difficult to prepare & require high degree of mixing. E.g. Insoluble solids are mixed with a vehicle to form suspension, Two immiscible liquids are mixed to form emulsion. solid mixers

PowerPoint Presentation:

Neutral mixtures They are static in behaviour. Neither mixing nor demixing take place unless a force is applied on the system. E.g. pastes, ointments, & powders. solid mixers

PowerPoint Presentation:

Why we perform the mixing process in solid dosage forms. Most common pharmaceutical operations. Normally a number of additives are added to manufacturing of tablet. So mixing of powders becomes an essential part of the process. When the dose of the active substance is high mixing is not a problem. But when the dose of the active substance is low, high amounts of adjuvant are added. Mixing is considered as a critical factor. Otherwise, a content uniformity of tablets dose not confirm to the pharmacopoeial specifications. Similarly weight variation increases. solid mixers

PowerPoint Presentation:

MECHANISM OF MIXING IN SOLID Segregation of particles occurs due to a number of reasons. Mixing can prevent it. The principal mechanisms in solid solid mixing are; Convective mixing It is achieved by the inversion of the powder bed using blades or paddles or screw element. A large mass of material moves from one part to another. Convective mixing is referred to as macromixing. Shear mixing In this type, the forces of attraction are broken down so that each particle moves on its own between regions of different composition & parallel to their surfaces. solid mixers

PowerPoint Presentation:

Diffusive mixing It involves the random motion of particles within the powder bed, thereby particles change their positions relative to one another. Diffusive mixing is sometimes referred to as micromixing. solid mixers

PowerPoint Presentation:

FACTORS AFFECTING MIXING OF SOLIDS Nature of the surface Rough surface of one of the components does not induce satisfactory mixing. This can be due to the entry of active substance in to the pores of the other ingredients. Density of the particles It is of minor importance. Demixing is accelerated when the density of the smaller particles is higher. This is due to the fact that dense material always moves downward & settles at the bottom. solid mixers

PowerPoint Presentation:

Particle size It is easy to mix two powders having approximately the same particle size. The variation of particle size can lead to separation, because the small particles move downward through the spaces between the bigger particles. Particle shape The ideal particle is spherical in shape for the purpose of uniform mixing. Particle charge Some particles exert attractive forces due to electrostatic charges on them. This can lead to separation or segregation. Propotion of materials The best results can be obtained if two powders are mixed in equal propotion by weight or by volume. solid mixers

PowerPoint Presentation:

EQUIPMENTS USED FOR MIXING IN SOLID DOSAGE FORMS solid mixers

PowerPoint Presentation:

Manual operated Pestle/mortar;- Classical & simplest equipment for grinding. In this method, the material is crushed by the application of attrition & pressure. In this both mortar & pestle are rotating. Heavy pestles provide the force of compression, which is an efficient process for wet grinding. This equipment cannot be provided with a sieve for continuous removal of fines. solid mixers

PowerPoint Presentation:

Power operated 1) AGITATOR MIXERS A) RIBBON BLENDER Principle;- it works on the principle of shearing & convective in action. Application Available in working capacity of 5 liters to 25 liters This blender is used to mix finely divided solids, wet solid mass, sticky & plastic solids. Uniform size & dense material can be easily mixed. It is used for liquid-solid & solid-solid mixing. solid mixers

PowerPoint Presentation:

Advantages High shear can be applied by using perforated baffles, which bring about a rubbing & break down aggregates. Disadvantages It is poor mixer, because movement of particles is two- dimensional. Shearing action is less than in planetary mixer. It is having fixed speed drive . solid mixers

PowerPoint Presentation:

SIGMA BLADE MIXER Principle;- it works on the principle of shearing & convective in action Application Jacketed construction available for heating & cooling applications. Available in working capacities of 5 liters to 2500 liters . Used in wet granulation process in the manufacture of tablets, pill masses & ointments. Used for solid-solid & liquid-solid mixing. solid mixers

PowerPoint Presentation:

Ideal for mixing, kneading of highly viscous mass, sticky &dough like products. Mixing of pastes, rubber, & heavy plastic masses. Applications in food, rubber, pharmaceutical & chemical industries. Advantages Sigma blade mixer creates a minimum dead space during mixing. Disadvantages It works at a fixed speed. solid mixers

PowerPoint Presentation:

PLANETARY ROTARY MOTION MIXER This mixer designed specially for semi-solids, pastes, ointments, viscous material, pill mass & tablet granulation masses. Principle;- it works on the principle of shearing & convective in action. Application Single planetary mixer is commonly use for light, medium viscosity products in the pharmaceutical, cosmetic & food industry. Double planetary mixer is used in chemicals, rubber & other allied industries. Low speeds are used for dry blending & faster speeds for the kneading action required in wet granulation. Steam jacketed bowls are used in the manufacture of sustained release products & ointments. solid mixers

PowerPoint Presentation:

Jacketed construction available for heating & cooling applications. Available in working capacities of 5 liters to 500 liters . Advantages speed of rotation can be varied so it is advantageous over sigma blade or ribbon type blender. Disadvantages It requires high power. It has limited size & is useful for batch work only. solid mixers

PowerPoint Presentation:

TUMBLING MIXERS WITHOUT A MIXING BLADE Principle;- It works on the principle of shearing & diffusive action of the surface. It consists of the metallic container which is rotated on its horizontal axis. The efficiency of a tumbling mixer highly depends on the speed of rotation. Therefore, the rate of rotation should be optimal, which depends on the size, shape of the tumbler& the nature of the material to be mixed. Common range is 30 to 100 rpm. solid mixers

PowerPoint Presentation:

TWIN- SHELL OR V- CONE BLENDER WITHOUT A MIXING BLAD Application Dry mixing of free flowing powders, granules. Available in working capacities of 5 liters to 5000 liters . Smaller models take a charge of 20 kg & rotate at 35 rpm, while larger models take a charge of about a 1 tonne & rotate at 15 rpm. Advantages Easy to clean & maintain. They handle large capacities. This equipment requires minimum maintenance. solid mixers

PowerPoint Presentation:

Disadvantages Needs high headspace for installation. It is not suitable for fine particulate system or ingredients of large differences in the particle size distribution, because not enough shears is applied. DOUBLE CONE BLENDER WITHOUT A MIXING BLADE Application For homogeneous mixing of dry powder or granules. For pharmaceutical, food, chemical & cosmetic products. For small amounts of powders. Available in working capacities of 5 liters to 5000 liters . Jacketed construction available for heating & cooling application. solid mixers

PowerPoint Presentation:

Advantages Easy to clean & maintain. Easy to operate, charge or discharge. They handle large capacities. This equipment requires minimum maintenance Disadvantages Needs high headspace for installation. It is not suitable for fine particulate system or ingredients of large differences in the particle size distribution, because not enough shear is applied. solid mixers

PowerPoint Presentation:

TUMBLING MIXERS WITH A MIXING BLADE TWIN- SHELL OR V- CONE BLENDER WITH A MIXING BLADE DOUBLE CONE BLENDER WITH A MIXING BLAD Principle, construction & working, uses all are same as the tumbling mixers without a mixing blade. Only agitator blades are added which have different advantages & disadvantages. The V cone blender & double cone blender with agitator blade are shown in figures. solid mixers

PowerPoint Presentation:

Advantages Baffles are useful for both wet & dry mixing. Wide range of shearing force can be applied with agitator bars permitting the intimate mixing of very fine as well as coarse powders. Disadvantages Attrition is large, size reduction of friable particles results. Cleaning may be a problem. solid mixers

PowerPoint Presentation:

3) CONTINUOUS TYPE MIXER A) BARREL TYPE MIXER Principle;- In a barrel type continuous mixer, the rotating shell keeps the material under tumbling motion. Application For homogeneous mixing of dry powder or granules. For pharmaceutical, food, chemical & cosmetic products. For small amounts of powders. solid mixers

PowerPoint Presentation:

Advantages Baffles are useful for both wet & dry mixing. Wide range of shearing force can be applied with agitator bars permitting the intimate mixing of very fine as well as coarse powders. Easy to operate, charge or discharge. They handle large capacities. This equipment requires minimum maintenance It is a continuous process so more amounts of materials can be mixed in compaired to the batch type mixer. solid mixers

PowerPoint Presentation:

Disadvantages Needs high headspace for installation. It is not suitable for fine particulate system or ingredients of large differences in the particle size distribution, because not enough shear is applied. Attrition is large, size reduction of friable particles results. Cleaning may be a problem. solid mixers

PowerPoint Presentation:

ZIGZAG TYPE MIXER Principle;- In a zigzag type continuous mixer, the rotating shell having several V shaped blenders which keeps the material under tumbling action. Application For homogeneous mixing of dry powder or granules. For pharmaceutical, food, chemical & cosmetic products. For small amounts of powders. solid mixers

PowerPoint Presentation:

Advantages Baffles are useful for both wet & dry mixing. Wide range of shearing force can be applied with agitator bars permitting the intimate mixing of very fine as well as coarse powders. Easy to operate, charge or discharge. They handle large capacities. This equipment requires minimum maintenance It is a continuous process so more amounts of materials can be mixed in compaired to the batch type mixer. solid mixers

PowerPoint Presentation:

Disadvantages Needs high headspace for installation. It is not suitable for fine particulate system or ingredients of large differences in the particle size distribution, because not enough shear is applied. Attrition is large, size reduction of friable particles results. Cleaning may be a problem. solid mixers

PowerPoint Presentation:

THANK YOU HAVE A GREAT DAY solid mixers