hargobind khorana presentation by nnres (cse) 1st year

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HARGOBIND Khorana : 

HARGOBIND Khorana Indian born Nobel Laureate

Agenda : 

Agenda Childhood Education Research Nobel Prize Achievements Family & Interests Conclusion

Childhood : 

Childhood Khorana born on – january 9th 1922. Place of birth – Raipur, Punjab. His father was a ‘Patwari’. He is the youngest of his family.

Multan-the town where Khorana studied : 

Multan-the town where Khorana studied

Slide 7: 

He completed his school life in D.A.V school in Multan . There he was influenced one of his teacher’s name Ratanlal

Slide 9: 

He Obtained his post graduate degree from University of Punjab in Lahore. At that time he was influenced greatly by a teacher named Mahan Singh

Slide 11: 

Government of India gave khorana an opportunity to go to England. There he did his Ph.D. degree at University of Liverpool His research was guided by Rojer J.S beer.

Slide 12: 

Eidgenossische Technische Hochschule

Cambridge University : 

Cambridge University

Khorana’s research at Cambridge University : 

Khorana’s research at Cambridge University Khorana carried out his research at Cambridge University between 1950 and 1952. He worked under Sir Alexander Todd. Here his interest in nucleic acid was strengthened.

Slide 15: 

University Of British Columbia

Slide 16: 

Khorana with his colleagues at British Columbia Research Council

Khorana’s research : 

Khorana’s research Professor Har Gobind Khorana was one of three scientists awarded the Nobel Prize in Physiology/Medicine in 1968 For their interpretation of the genetic code and its function in protein synthesis.

Slide 19: 

The Structure of DNA One of the most important components of Khorana’s research is DNA.

The Genetic Code : 

The Genetic Code

Amino Acid (Structure) : 

Amino Acid (Structure) Amino acids are the building blocks of Proteins. Khorana supplemented details about which serial combinations of nucleotides form specific amino acids.

Slide 22: 

The role of Codons Khorana found that the nucleotide code is always transmitted to the cell in groups of three, called codons. Khorana also showed that some of the codons prompt the cell to start or stop the manufacture of proteins.

Slide 23: 

Nobel Prize

DNA Protein Synthesis : 

DNA Protein Synthesis Protein synthesis the process in which cells build proteins. The term is sometimes used to refer only to protein translation but more often it refers to a multi-step process, beginning with amino acid synthesis and transcription of nuclear DNA into messenger RNA which is then used as input to translation

Slide 25: 

Robert W. Holley Name: Robert William Holley Born : January 28,1922 Nationality:U.S. Known for: describing the structure of alanine transfer RNA , linking DNA and protein synthesis. Notable awards: Nobel Prize in Physiology or Medicine in 1968

Marshall Warren Nirenberg-Profile : 

Marshall Warren Nirenberg-Profile Name: Marshall Warren Nierenberg Born: April 10,1927 Nationality: U.S. Alma mater: University of Michigan Known for: genetic code

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Notable awards: Nobel Prize in Physiology or Medicine in 1968

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University Of Florida In 1948 Nirenberg Passed out from the university of Florida with Bachelor of Science Degree and Masters Degree in Zoology.

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University Of Michigan In 1957 he completed His PhD work on sugar transport in tumor cells

Massachusetts Institute of Technology : 

Massachusetts Institute of Technology In 1970 Khorana became the Alfred Sloan Professor of Biology and Chemistry at the MIT where he worked until retiring in 2007. He is a member of the Board of Scientific Governors at The Scripps Research Institute, and currently holds Professor Emeritus status at MIT.

Oligonucleotides : 

Oligonucleotides

Slide 32: 

Family & Interests Khorana married Esther Elizabeth Sibler now deceased, who was of Swiss origin, in 1952. They have three children: Julia Elizabeth , Emily Anne ,Dave Roy He takes daily long walks, carrying with him an index card to record any ideas that might come to him. He also enjoys going on hikes and listening to music.

Other Awards / Achievements : 

Other Awards / Achievements Hari Om Ashram Prerit Vikram Sarabhai Award (1988) H. K. Firodia (1997) Rockwell Medal (1997) Padma Shri in 1998. Padma Bhushan in 1999. Padma Vibhushan in 2009. H. J. Bhabha Memorial Award (1999-2000) FICCI (1997-98) ANACON - 1998

Conclusion Thought : 

Conclusion Thought “ You stay intellectually alive longer if you change your environment very often ”

Slide 35: 

Thanks!

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