Customers publishing raw images of �Para

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Customers publishing raw images of µParaflo® microfluidic chip data

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Rogaev EI. (2005) Small RNAs in human brain development and disorders. Biochemistry (Mosc) 70(12), 1404-407. [abstract] LC Sciences’ customers have been publishing raw images of its µParaflo® microfluidic chip data since the company began offering the microRNA microarray service back in 2005.

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Lin SL, Chiang A, Chang D, Ying SY. (2008) Loss of mir-146a function in hormone-refractory prostate cancer. RNA 14(3), 417-24. [abstract] The exceedingly high quality of the data coming from these chips makes the results so clear that it makes sense to illustrate by showing the actual scanned image of the array itself.

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Gillardon F, Mack M, Rist W, Schnack C, Lenter M, Hildebrandt T, Hengerer B. (2008) MicroRNA and proteome expression profiling in early-symptomatic Æ-synuclein(A30P)-transgenic mice. Proteomics Clin Appl 2(5), 697-705. [abstract] “We are continually amazed that our customers choose to publish images of the array in the main text of the articles as a means present research results. This is not something you typically see with data from a standard microarray and reflects the strength of our advanced technology”. Chris Hebel, LC Sciences LLC.

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He PA, Nie Z, Chen J, Chen J, Lv Z, Sheng Q, Zhou S, Gao X, Kong L, Wu X, Jin Y, Zhang Y. (2008) Identification and characteristics of microRNAs from Bombyx mori. BMC Genomics 9(1), 248. [abstract] LC Sciences’ customers who are using the company’s microarray service for analyzing microRNA (miRNA) expression profiles and for discovery of novel small RNAs have published over 100 research articles in top tier peer-reviewed journals.

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Song G, Wang L. (2008) Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res 36(18), 5727-35. [abstract] The publications to date by LC Sciences’ customers span a diverse range of study areas, including cancer research, neuroscience, cardiovascular research, reproductive biology, plant science, virology, stem cell research, immunology, and small RNA discovery.

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Talebizedah Z, Butler M, Theodoro M. (2008) Feasibility and Relevance of Examining Lymphoblastoid Cell Lines to Study Role of microRNAs in Autism. Autism Research 1(4), 240-50. [abstract] Their miRNA profiling service has provided a tool for many researchers to explore and examine a wide assortment of miRNA cellular networks and the resulting publications are often the first description of miRNA activity in these systems.

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Sun Y, Wu J, Wu SH, Thakur A, Bollig A, Huang Y, Joshua Liao D. (2008) Expression profile of microRNAs in c-Myc induced mouse mammary tumors. Breast Cancer Res Treat [Epub ahead of print]. [abstract] LC Sciences’ miRNA profiling service, powered by its µParaflo® microfluidic technology, provides quick, reliable, fully analyzed data enabling researchers to immediately move forward with innovative research, and publish their results faster.

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Lin SL, Chang DC, Chang-Lin S, Lin CH, Wu DT, Chen DT, Ying SY. (2008) Mir-302 reprograms human skin cancer cells into a pluripotent ES-cell-like state. RNA 14(10), 2115-24. [abstract] Microarray results require extensive validation prior to publication. The speed with which researchers using this miRNA profiling service have published their discoveries demonstrates the high-quality and reliability of these results.

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Qian S, Ding JY, Xie R, An JH, Ao XJ, Zhao ZG, Sun JG, Duan YZ, Chen ZT, Zhu B. (2008) MicroRNA expression profile of bronchioalveolar stem cells from mouse lung. Biochem Biophys Res Commun 377(2), 668-73. [abstract] About µParaflo® Technology - The µParaflo® technology is a microfluidic platform for in situ parallel synthesis of biomolecular chips and miniaturization of bioassays including binding and enzymatic reactions.

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Zhang Y, Zhou X, Ge X, Jiang J, Li M, Jia S, Yang X, Kan Y, Miao X, Zhao G, Li F, Huang Y. (2009) Insect-Specific microRNA Involved in the Development of the Silkworm Bombyx mori. PLoS One. 4(3), e4677. [abstract] This unique platform technology is based on a new class of three-dimensional pico-liter microfluidic reaction devices, and a digital light controlled synthesis method that employs conventional oligonucleotide or peptide synthesis chemistry; a completely programmable process.

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Simone NL, Soule BP, Ly D, Saleh AD, Savage JE, Degraff W, Cook J, Harris CC, Gius D, Mitchell JB. (2009) Ionizing radiation-induced oxidative stress alters miRNA expression. PLoS One 4(7), e6377. [abstract] The seamless integration of these multidisciplinary technologies enables a significant advance in parallelization, miniaturization, customization, and automation.

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Lukiw WJ, Cui JG, Li YY, Culicchia F. (2008) Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). J Neurooncol 91(1), 27-32. [abstract] About LC Sciences - LC Sciences is a genomics and proteomics products company offering a comprehensive line of DNA, RNA, and peptide microarrays for nucleic acid/protein profiling and functional analysis, biomarker-discovery, novel drug screening, and the custom development of miniaturized assay devices for diagnostics and biosensing applications.

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Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. (2009) MicroRNA regulation of DNA repair gene expression in hypoxic stress. Cancer Res 69(3), 1221-9. [abstract] Based on the µParaflo® microfluidics technology, LC Sciences’ innovative products offer significant flexibility and customization capability for rapidly evolving, diverse customer needs. In an era of rapid technological advancement, LC Sciences offers service products which enable efficient one-stop solution for assays of DNA, RNA, protein, enzymes, antibodies, or small molecules.