CELLUL ppts

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Prof. V. K. Chatap Assistant Professor Department of Pharmaceutics H. R. Patel Institute of Pharmaceutical Education and Research, shirpur. 1 CELLULOSE DERIVATIVES

CONTENT : 

CONTENT Cellulose Application What is Cellulose derivatives Types of cellulose derivatives Application of cellulose derivatives References

WHAT IS CELLULOSE DERIVATIVES: 

WHAT IS CELLULOSE DERIVATIVES Pharmaceutically used cellulose derivatives obtained by either mechanical or chemical processing or both. The hydroxyl groups of cellulose can be partially or fully reacted with various reagent to afford derivatives with useful properties. Pure cellulose additional treatment by HCL produced various cellulose derivatives.

TYPES OF CELLULOSE DERIVATIVES: 

TYPES OF CELLULOSE DERIVATIVES Microcrystalline cellulose Cellulose acetate pthalate Hydroxy ethyl cellulose Methyl cellulose Hydroxy propyl cellulose Carboxy methyl cellulose Hydroxy propyl methyl cellulose Hydroxy propyl methyl cellulose pthalate Hydroxy ethyl methyl cellulose Ethyl cellulose

Advantages: 

Advantages Improve stability of drug. Good Lubrication Good binding properties Rapid disintigration Good flowing properties Reduced friability & weight loss Excellent compression & hardness

Microcrystalline cellulose: 

Microcrystalline cellulose Synonyms: Celex , cellulose gel , fibrocel. Empirical Formula : (C 6 H 10 O 5 ) n n=220 Molecular Weight : 36000 Function Category : Adsorbent, Suspending agent, table diluent Application in Pharmaceutical Formulation : →Binder (20-90%) → Disintigrant (5-15%) → Antiadherent (5-20%) → Lubricant →Diluent (20-90%) Description: White,Odorless, Tasteless,Crystalline power

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Brand : LIBRAWCEL Grade Particle Size Standards Average Particle Size Moisture % Librawcel 101 60 Mesh Not more than 1% +200 Mesh Less than 30% 50 Micron 5 Librawcel 102 60 Mesh Not more than 8% +200 Mesh Less than 45% 150 Micron 5 Librawcel 103 60 Mesh Not more than 1% +200 Mesh Less than 30% 50 Micron 3

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Typical properties Density(bulk):0.337g/cm 3 Density(tapped):0.478g/cm 3 Density(true):1.512-1.668g/cm 3 Flow ability: 1.41 g/s Melting point: 260-270 0 c Moisture content: < then 5 % w/w Solubility: Slightly soluble in NAOH Precaution : Irritant to eye so recommended eye protection. Incompatibilities : With strong oxidizing agents.

Cellulose acetate pthalate: 

Cellulose acetate pthalate Synonyms : cellacephate Function Category : coating agent Application in Pharmaceutical Formulation : →used in enteric film coating material (0.5-9%) →matrix binder for tablets and capsules Description: Hygroscopic, White to off White ,Free-flowing powder

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Typical properties Density(bulk): 0.260 g/cm 3 Density(tapped): 0.266 g/cm 3 Melting point: 192 0 C Moisture content: 2.2% Solubility: <10%w/w Incompatibilities : With ferrous sulfate , Fecl 2 , Cacl 2 , Hgcl 2 , lead acetate , strong oxidizing agent. Precaution : Irritant to eye should be handled in a well ventilated environment.

Cellulose Acetate: 

Cellulose Acetate Synonyms : Acetyl cellulose Empirical Formula :(C 6 H 12 O 7 ) n Molecular Weight : 38000 Function Category : Extended release agent,Diluent Application in Pharmaceutical Formulation : →used in sustein release & taste masking →used in trasdermal drug delivery Description: Free flowing pellets, tasteless, slightly odour of acetic acid

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Typical properties Density:1.3 g/cm 3 Melting point: 230-300 0 c Glass transition temperature: 170-190 0 c Solubility: soluble in acetone-water dichloromethane-ethanol Viscosity: 10-230 mPa s Incompatibilities : With strongly acidic or alkaline substance Precaution: Cellulose acetate irritant to eye so eye protection should be worm

Hydroxy ethyl cellulose: 

Hydroxy ethyl cellulose Synonyms : cellulose hydroxy ethyl ether Molecular Weight : 38000 Function Category : Suspending agent, Binder Coating agent, Thickening agent Application in Pharmaceutical Formulation : →Opthalmic & Topical formulation → Cosmetic preparation Description: Hygroscopy powder, odourless, tasteless, cream to white colour

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Typical properties Density(bulk):0.35-0.61g/cm 3 Melting point: 135-140 0 c(softens) 205 0 C(Decompose) Moisture content: < then 5 % w/w Solubility: soluble in Hot & Cold water Insoluble in ethanol, ether, toluene Viscosity: 2-20000 mPa s cello size (2-3000) Natrosol (>3000) Incompatibilities : With fluorescent dyes , quaternary disinfectant. Precaution: Irritant to eye so recommended eye protection.

Hydroxy propyl cellulose: 

Hydroxy propyl cellulose Synonyms : Hyprolose Molecular Weight : 50000-125000 Function Category : Suspending agent, Binder Coating agent, Emulsifying agent Application in Pharmaceutical Formulation : → Oral & Topical formulation → binder in tableting process (2-6% w/w ) → extended drug release(15-35% w/w) Description: odourless, tasteless, white to slightly yellow colour.

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Typical properties Density(bulk): 0.5 g/cm 3 Melting point: 130 0 c(softens) 260-275 0 cDecompose) Moisture content: 4 % w/w(at 50%relativehumidity) 12%w/w(at 84% relative humidity) Solubility: soluble 1 in 10 part dichloromethane 1 in 2.5 part ethanol 1in 2 part methanol Viscosity: 75-3000 mPa s Incompatibilities : With phenol derivatives such as methylparaben , propylparaben. Precaution: Irritant to eye so recommended eye protection.

Hydroxy propyl methyl cellulose: 

Hydroxy propyl methyl cellulose Synonyms : Hypromellose Empirical Formula : C 56 H 108 O 30 Molecular Weight : 10000-1500000 Function Category : Coating agent, Suspending agent, tablet binder Application in Pharmaceutical Formulation : →Binder (2-5%w/w) →Thickening agent (0.45-1%w/w) →Emulsifier, Suspending agent →Plastic bandage Description : White, Odorless, Tasteless

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Typical properties Density(bulk):0.341 g/cm 3 Density(tapped):0.557g/cm 3 Density(true):1.326g/cm 3 Melting point: 190-200 0 c Moisture content: depend on initial moistur content, temperature, relative humidity Solubility: soluble in cold water insolubal in chloroform, ethenol, ethers Incompatibilities : With oxidizing agents , metallic salts or ionic organics. Precaution: Irritent to eye so recommended eye protection

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Grade of HPMC Grade Nominal Viscosity( mPa s) K100LVP 100 80-120 K4M 4000 3000-5600 K15MP 15000 12000-21000 K100MP 100000 80000-120000 E1OMP CR 10000 8000-13000 E4MP 4000 3500-5600 E3 PREM LV - 2.4-3.6 E5 PREM LV - 4-6 E6 PREM LV - 5-7 E15 PREM LV - 12-18 K3 PREM LV - 40-60 E50 PREM LV - 2.4-3-6

Powder cellulose: 

Powder cellulose Synonyms : Arbocel Empirical Formula : (C 6 H 10 O 5 ) n n=500 Molecular Weight : 243000 Function Category : Suspending agent, tablet diluent disintigrant Application in Pharmaceutical Formulation : →Binder (5-25%w/w) →Disintigrant (5-15-1%w/w) →Glident(1-2%) →Plastic bandag Description : White, Odorless, Tasteless

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Typical properties Density(bulk):0.139-0.391 g/cm 3 Density(tapped):0.210-0-481 g/cm 3 Density(true):1.5 g/cm 3 Moisture content: < then 5 % w/w Solubility: Slightly soluble 5% in NAOH Incompatibilities : With strong oxidizing agent. Precaution: Irritent to eye so recommended eye protection.

Carboxyl methyl cellulose : 

Carboxyl methyl cellulose Synonyms : carmellose Chemical formula : C 8 H 16 NaO 8 Molecular formula : 90000-700000 Properties : → Water soluble →Stable at pH 5-10, best at 7-9 pH →At pH 3 CMC is insoluble → Fine Film Forming Properties → Resistance to oil Greases & Solvents

References: 

References Raymand C. Rowe , Handbook of pharmaceutical excipients , published by Royal pharmaceutical society of great Britain ,London ,4 th edition page no. 108-122,283-293 Goran Alderbond, Pharmaceutical powder compaction technology , material for direct compression, page no. 428-440 Excipient toxicity and safety , Myra L. Weiner(volume 103) William J Reilly ,Remington’s pharmaceutical science, Pharmaceutical Necessities 8 th edition page no, 1084 Y. Nishiyama, P. Langan, H. Chanzy (2002). "Crystal Structure and Hydrogen-Bonding System in Cellulose Iβ from Synchrotron X-ray and Neutron Fiber Diffraction". 124 (31): 9074–9082.

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