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https://thegenf20plus.com/ Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise

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BioMed Central Page 1 of 2 page number not for citation purposes Journal of the International Society of Sports Nutrition Open Access Poster presentation Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to and peak force production during resistance exercise Tim Ziegenfuss Jamie Landis and Jennifer Hofheins Address: The Center for Applied Health Science Research Division of Sports Nutrition and Exercise Science Fairlawn OH 44333 USA Email: Tim Ziegenfuss - tziegenfusswadsnet.com Corresponding author Background Many of the positive adaptations resulting from resistance exercise training i.e. increased muscle mass and strength decreased fat mass are thought to be mediated in part by exercise-induced increases in growth hormone GH. One ingredient that has shown clinical promise in elevating GH is the acetylcholine precursor alpha-glycerylphospho- rylcholine A-GPC. The purpose of this study was to examine the effects of a supplement containing primarily A-GPC on serum GH levels explosive performance and post-exercise substrate oxidation. Methods Using a randomized placebo-controlled crossover design seven men mean ± SD age height weight body fat: 30.1 ± 7.3 y 179.2 ± 7.4 cm 87.3 ± 11.6 kg 18.1 ± 5.9 with at least two years of resistance training experi- ence ingested 600 mg A-GPC as AlphaSize™ or a placebo 90-minutes prior to completing 6 sets × 10 repetitions of Smith Machine squats at 70 of their pre-determined 1- repetition maximum. At 30-minutes post-exercise resting metabolic rate RMR and respiratory exchange ratio RER were measured with indirect calorimetry to assess post-exercise caloric expenditure and carbohydrate and fat oxidation respectively. Immediately following RMR and RER measurements subjects performed three sets of bench press throws at 50 of their pre-determined 1-rep- etition maximum to assess peak force peak power and rate of force development. All trials were performed after an overnight fast a 48-hour abstention from intense exer- cise and during the same time of day to minimize diurnal variation. Serum samples were obtained prior to exercise and again 0 5 15 30 60 90 and 120 minutes post-exer- cise. Hormone concentrations were analyzed in duplicate by Quest Diagnostics ® via immunoassay. Statistical evalu- ation of the data was accomplished using dependent t- tests peak force peak power rate of force development and repeated measures ANOVA GH RMR RER. Differ- ences were considered "significant" at P ≤ 0.05. Results Compared to baseline pre values peak GH increased 44-fold during A-GPC from 0.19 ± 0.06 to 8.4 ± 2.1 ng/ mL vs. 2.6-fold during placebo from 1.9 ± 0.8 to 5.0 ± 4.8 ng/mL P 0.03 Figure 1. Peak bench press force was 14 greater in A-GPC 933 ± 89 N vs. placebo 818 ± 77 N P 0.02. Trends toward higher peak bench press power P 0.13 and lower post-exercise RER P 0.12 were noted in the A-GPC trial. Conclusion These data indicate that a single 600 mg dose of A-GPC as AlphaSize™ when administered 90 minutes prior to resistance exercise increases post-exercise serum GH and peak bench press force. In contrast A-GPC had no statis- tically significant effect on peak power rate of force devel- opment RMR or cardiovascular hemodynamics i.e. heart rate and blood pressure. Future work should exam- from 2008 International Society of Sports Nutrition Conference and Expo Las Vegas NV USA. 9–10 June 2008 Published: 17 September 2008 Journal of the International Society of Sports Nutrition 2008 5Suppl 1:P15 doi:10.1186/1550-2783-5-S1-P15 supplement title pProceedings of the Fifth International Society of Sports Nutrition ISSN Conference and Expo/p /title editorPaul LaBounty and Jose Antonio/editor noteMeeting abstracts – A single PDF containing all abstracts in this Supplement is available a href" http://www.biomedcentral.com/content/files/pdf/1550-2783-5-S1-full.pdf"here/a./note /supplement This abstract is available from: http://www.jissn.com/content/5/S1/P15 © 2008 Ziegenfuss et al licensee BioMed Central Ltd.

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Publish with BioMed Central and every scientist can read your work free of charge "BioMed Central will be the most significant development for disseminating the results of biomedical research in our lifetime." Sir Paul Nurse Cancer Research UK Your research papers will be: available free of charge to the entire biomedical community peer reviewed and published immediately upon acceptance cited in PubMed and archived on PubMed Central yours — you keep the copyright Submit your manuscript here: http://www.biomedcentral.com/info/publishing_adv.asp BioMedcentral Journal of the International Society of Sports Nutrition 2008 5Suppl 1:P15 http://www.jissn.com/content/5/S1/P15 Page 2 of 2 page number not for citation purposes ine how resistance exercise + A-GPC affect the GH-IGF axis and their associated family of binding proteins. Acknowledgements Supported in part by a research grant from Chemi Nutra White Bear Lake MN. None of the authors has any conflict of interest. Figure 1

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