general Immunology

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Dr Alok Tripathi Department of Biotechnology aquaimmuno@yahoo.co.in Outline of Immune Response

PowerPoint Presentation: 

Juncture point for Non Specific & Specific Immune Response ↑ Showing the Significance of Specific & Non Specific IR

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Host Pathogens Environment Diseases Immune Response Virulency Interaction metabolism

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Nonspecific Cellular Response Nonspecific Humoral Specific Humoral Specific Cellular Properties Present from birth Operate against any nonself Unaffected to prior exposure Acquired & Adoptive Tailored against individual pathogens Enhanced by prior exposure Who do it? Cells: Macrophages, Monocytes , PMN Acute phase proteins, like CRP, Ceruloplasmin , Transferrine Lysozymes etc Immunoglobuline T-Lymphocytes What they do? Phagocytosis The whole components cause hindrance in establishment of pathogen Form Ag- Ab complex to neutralized the harmful components Apoptosis, Killing by Cytotoxic Lymphocytes

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P

PowerPoint Presentation: 

Outline of Acquired Immune Response

T Cell Activation: 

T Cell Activation Kill Endogenous Antigen Activate CTL Kill Infected Cell Exogenous Antigen Activate Th Stimulate Macrophage Endosomal Pathogens

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APC [B-Cell] Th Cell Y Ag Y Y MHC-II P B7 CD-28 TCR CD-40 CD-40L CK CO-STIMULATORY SIGNALS Nucleus Singling Cascades Processing & Presentation of Ag

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P-Effect=Pathogen Effect; H-Effect= Host Effect; APP= Acute Phage Proteins; Whole Process is Manifested as Inflammation Innate Immunity Acquired Immunity Result Humoral (APP) Cellular (Phagocytosis) Processing Presentation T Cell Response B-Cell Response P-Effect H-Effect P-Effect H-Effect H-Effect H-Effect H-Effect H-Effect 1  External –internal environment interface  ¬ X X X X X X Immunotolerence 2  ® ¬ X X X X X X Immunotolerence 3  ¬ 4  ® ¬ ® ¬ ® ® ®¬ Normal IR 5  ® ¬ ® ¬ ® ® ®¬ Normal IR 6  ® ¬ ® ¬ ® ® ®¬ Normal IR 7  ® ¬ ® ¬ ® ® ®¬ Normal IR 8 0 ¬ ® ¬ ® ® ®¬ Autoimmunity 9 0 ¬ ® ¬¬¬ ®®® ®®® ®¬¬¬ ®¬¬¬ Hypersenstivity 10 0 ¬ ® ¬¬¬ ®®® ®®® ®¬¬¬ ®¬¬¬ Hypersenstivity 11 0 ¬ ® ¬ ® ® ® Autoimmunity 12  ® ¬ ® ¬ ® ® ®¬ Normal IR 13  ® ¬ ® ¬ ® ® ®¬ Normal IR 14  ® ¬ ® ¬ ® ® ®¬ Normal IR 15 ® ® ¬ ® ¬ ® ® ®¬ Normal IR 16 ®  C  C  C  C  C  C  C 17 ®  C  C  C  C  C  C  C 18 ®  C  C  C  C  C  C  C

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Wliwni ni Moltes gràcies Juspajarkätam Hvala Betam amesegënallô Asante Tangkiu tumas Yin acaa muoc Wliwni Mercès Juspaxar Puno hvala Quialva' Sikomo kwejinji Ta Mersi Oliwni Uan tabuan Yuspagara Hvala lijepa Ashoge Asante sana Ang hmèn yá Emitekati Mantiox chawe Si yuus maasi Dios pagarakátam Dêkuji Áshood Yokoke Nitsíniiyi'taki Daarim Maketai Si yu'os ma'ase' Yusulupay Dik' Ihe edn Yakoke Baraka Pounsikou Yuuminsame Ngua tsaa xlay'be hii Yuspagarkàtam Barka Ahíyi'ee Wokolix awölö Hvala Dank u Wapsaw Barkal Yuspagaràtam Puorra bebe la Mvto Wokol a wala Hvala vam Dank je Thawerapsaw Barkalla Sayol Pidamayado Ahoo Ch'ahp'ei'x ta'p'a Trugarez Dank u wel Gadda ge Wa'-do Sag olun Pidamaya yedo Ahó Yuj wal dios Trugarez deoc'h Dank je wel Dankie Néá'eshe Tæshækkür elæyiræm Pidamaya ye Ahókacira Kili so Trugarez dit Bedankt Baie dankie Néá'êshemeno Chokh sag olun Tak Shukran Kili so chapur Mersi dit I ni che Ntyox teru ' Hahóo Masuma Mange tak Shukran gazilan Kini so Ho trugarekaat Kadinche Seé Zikomo Na somi saisai Lac jak Mamnuun Kini so chapur Boche' Kadinche la Tsin'aen Zikomo kwambiri Tiang matur suksama Lac jak ko ih lu SaHHa Tavtapuch Sa-aun Ù rú èsé Iyayraykere Zikomo kwambili Matu suksama Dogedinh El-hamdullah Tav Nasima Dua Netjer en ek Hioy'oy Zikomo Matur suksme Xisrigidisddhinh Barak llahu fik Tavssi Orio muno Dua Netjer en etj Gui lah hui te ha Zikomo kwambili Tai merbani Musi Grazias Limlemtsch Webaale Imbuya mono Gui lah hui mi a de Zikomo I ni ce Musicho Shnorhagallem Ura Wanyala Tángeyoo Gui lah hui dui dui ma Masiem Aw ni ce Snachailya Shterakravetsun Urako Blagodarya Thank you Ghu long khu me-ah Mahsie Nba Snachalhuya Shenorhagal em Marahaba Mersi Thanks Gu lah hu ma de Zikomo Nse Nahnachailya Shad shenorhagal em Marahabha Mnogo blagodarya Ta Saeamat kimo Zikomo kwambiri Rekhmet Nahnachalhuya Sh'norhakal em Dew re-dallo dheugh-why Akeva Cheers Alíila Ndatenda Eskerrik asko Nenachailya Shnorhakalutjun Durdala dywy Uninang Thenks Kano Ndinotenda Mila esker Nenachalhuya Merci Durdaladawhy Maraba Enks Kanobi Tatenda Esker mila Snachailya Multsãnjescu Gwra'massi Chezu ba Ic þancas do Tá Tinotenda Esker aunitz Snachalhya Meda w'asé Merastawhy Chezu tinbade Ic þancie þe Alíilamoolo Mazviita Eskerrik anitx Nenachailya Meda wo ase Meur ras Amyaji chezu tinbade Ic sæcge eow þancas Kanoomoolo Maita basa Mauliate Nenachalhya Meda wo ase paa paa paa Meur ras dhis Juu na Thank ya Kanopalammoolo Maita zvenyu Dziakuju Snachailya Basima Grazia Juu goor maniSh Dankon Ju falem nderit Yewo Dziákuj Snachalhuya Basimta À ringraziè vi Shukria Dankon al vi Faleminderit Yewo chemene Tsikomo Nahnachailya Basimeh À ringraziavvi Bakhshish Tänan Faleminderit shumë Twalumba Twa to te la Nahnachalhuya Mesi Kinanâskomitin 'Ácha-ma Aitäh Bïyan bolzïn Yewo Dhanyabad Nenachailya Hawit basima chim raba Kinanâskomitinawaw Matiosh chawe Ole meheks Ondapandula unene Yewo chemene Ozasro dhanyabad Nenachalhuya Taudi E'kosi Gràsce Aitih Amesegënallô Yewo chomene Tangkiu Shukuriyyaa Gracies Têniki Doh je Aiteh