Root Deep Absolute Advance III - Clinical Backbone

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Have a look at this presentation to know about the Root Deep which is india's first an advanced hair therapy by Brillare Science. Root Deep‐Absolute Advance III is the thoroughly researched natural cosmetic science against hair fall & decreased hair density. For more information, you can visit www.brillarescience.com/rootdeep.html .

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Presentation Transcript

Clinical Backbone:

Clinical Backbone

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4 Nourishing oils 10 Phytonutrient extracts 17 Keratin resembling plant amino acids Fall Reduction Root Energizing Blockage Clearing Anti Scalp Ageing Dandruff Removal Shaft Strengthening Volumizing Instant Shine Smoothening Frizz Control 10 Actions against all 5 concerns of hair fall and decreased hair density / growth on all 3 parts of hair . The Everything (Hair) Therapy

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Concern Active Ingredient Efficacy data Formulation details Fall Reduction Pisum sativum sprout extract Increase of growth coefficient (A/T) by 78% in 12 weeks with improvement in hair and scalp quality by more than 80% Root Deep Hydroil Ocimum basilicum hairy root culture extract 23% increase in dermal papilla cells after 1 month 30.7% decrease in hair fall in 2 months Root Deep Hydroil Pterocarpus marsupium bark extract Reduction of hair fall in male volunteers with androgenic alopecia: Frontal zone – 33% in 4 months Occipital zone – 46% in 4 months Root Deep Hydroil Root Deep Shampoo Root Energizing Plant extracts with Hexapeptides-11 Around 20% decrease in hair removal due to enlargement of hair bulb after 5 applications Elementi Puro Root Recharge synergy Vanillyl Butyl Ether 66.4% increase in scalp microcirculation(10 Minutes after application) Increase in IGF-1 production that will lead to increase in Anagen hair density Elementi Puro Root Recharge synergy Blockage Clearing Ocimum basilicum hairy root culture extract Upto 80% reduction in sebum as compared to 70% with Finasteride after 72 hours Root Deep Hydroil Zinc PCA +65% of Anti 5- α reductase activity compared to positive control in 28 days Elementi Puro Root Recharge synergy Anti Scalp Aging Pterocarpus marsupium bark extract 54% of reduction in glycation after 15 days 78% of free radical inhibition in spot laboratory studies (in tubo ) Root Deep Hydroil Root Deep Shampoo Dandruff Removal Piper nigrum fruit extract and Inga alba bark extract Effective against dandruff-causing bacterial strain at low MIC Around 40% reduction in dandruff after 42 days Around 50% reduction in sebum 42 days Root Deep Hydroil Root Deep Shampoo Root Deep Intenso Fluid Shaft Strengthening Hydrolyzed Pea Protein +4.0 % increase in tensile strength of Hair after each application +4.3 % increase in Cross section area of Hair after each application +5.71 % increase in Hair moisture after each application Root Deep Shampoo Root Deep Intenso Fluid

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++++ Proven Hair Fall reduction

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Pisum sativum sprout extract +++ +++ Study design I Study period of 12 weeks used twice daily 20 volunteers of age 21-37 17 females with hair in telogen phase > 15% 3 males with hair in telogen phase > 20% Incorporated in Root Deep Hydroil

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Results +++ Effect on hair fall

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Results +++ Reduction of Hair fall

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Results +++ Effect on A/T ratio

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Results +++ Response from volunteers

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+++ +++ Study design II Study period of 14 days used twice daily 10 volunteers of age 46-60 4 females 6 males Pisum sativum sprout extract Incorporated in Root Deep Hydroil

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Results +++ Effect on the expression of dermal papilla signaling molecules Noggin – A protein that shortens the telogen phase FGF-7 - Fibroblast growth factor – 7 that initiates new anagen phase

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Ocimum basilicum hairy root culture extract +++ +++ Biotechnologically derived, holy plant extract with Anti 5-alpha reductase activity. Provides nourishment to starving hair roots & promotes fuller, denser hair. 5α reductase is the key target enzyme in the inhibition of hair loss. Basil root Culture extract inhibit 5α reductase . Testosterone will not convert into dihydrotestosterone (DHT) in absence of 5α reductase .   The results showed a clear concentration dependent inhibition of 5α reductase . Consequently, Basil root Culture extract was able to reduce hair loss in people with androgenic alopecia. Incorporated in Root Deep Hydroil

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Results +++ Increased proliferation of Dermal papilla cells

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Ocimum basilicum hairy root culture extract +++ +++ Study period of 2 months used once daily 21 volunteers of age 25-67 with daily hair loss > 100 strains 19 females 2 males Study design Incorporated in Root Deep Hydroil

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Results +++ +++

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Pterocarpus marsupium bark extract +++ +++ Study period of 6 months used once daily against placebo 40 male volunteers of with androgenic alopecia Study design Incorporated in Root Deep Hydroil Root Deep Shampoo

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Results +++ +++

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++++ Proven Root Energizing

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Plant extracts with Hexapeptides-11 +++ +++ Plant extracts like sugar cane extract, Lemon fruit extract, Apple fruit extract, green tea leaf extract along with Hexapetides-11 restores hair and scalp vitality at cellular level and energizing hair bulb Incorporated in Elementi Puro Root Recharge Synergy

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Plant extracts with Hexapeptides-11 +++ +++ Study period of 5 days used once daily 15 volunteers of age 30-60 with hair length of not less than 12 inches Study design

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Results +++ +++

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Results +++ +++

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Vanillyl Butyl Ether +++ +++ Enhances microcirculation of blood flow with lesser irritation and warming sensation Incorporated in Elementi Puro Root Recharge Synergy

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Results +++ Increase in Blood flow

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Results +++ Effect on the production of IGF-1

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++++ Proven Blockage Clearing

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Ocimum basilicum hairy root culture extract +++ +++ Biotechnologically derived, holy plant extract with Anti 5-alpha reductase activity. Provides nourishment to starving hair roots & promotes fuller, denser hair. 5α reductase is the key target enzyme in the inhibition of hair loss. Basil root Culture extract inhibit 5α reductase . Testosterone will not convert into dihydrotestosterone (DHT) in absence of 5α reductase .   The results showed a clear concentration dependent inhibition of 5α reductase . Consequently, Basil root Culture extract was able to reduce hair loss in people with androgenic alopecia. Incorporated in Root Deep Hydroil

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Inhibition of 5 α reductase Results +++ +++

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Zinc PCA +++ +++ Zinc salt of pyrrolidone carboxylic acid, a double acting complex that optimally allies the beneficial effects of zinc and L-PCA, physiological components of the organism. Incorporated in Elementi Puro Root Recharge Synergy

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Zinc PCA +++ +++

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Zinc PCA +++ +++ Inhibition of 5 α reductase Pre-incubation of human Dermal fibroblasts in presence of Zinc PCA / Zinc chloride and Addition of radioactive (titrated) Testosterone and incubation for 24 hours / preparation of cellHomogenates by sonication and Radioactivity measurement Anti 5-alpha reductase activity of Zinc PCA (+65%) much higher than Zinc chloride (+45%) Intrinsic activity of Zinc PCA greater than equimolar quantity of Zinc chloride. Study design

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Results +++ +++ Inhibition of 5 α reductase

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Zinc PCA +++ +++ Seboregulatory activity Sebometric study on 2 groups of 16 volunteers after 28 daily application on the half forehead with a cream containing 1% Zinc PCA vs Placebo and non-treated zone Study design Results

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Zinc PCA +++ +++ Antimicrobial activity Minimum Inhibitory Concentration of Zinc PCA was identified and optimized for various bacterial and fungal strains. Study design Results

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++++ Proven Anti scalp Aging

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Pterocarpus marsupium bark extract +++ +++ Anti glycation activity Against aminoguanidine as positive control Study design Incorporated in Root Deep Hydroil Root Deep Shampoo Results

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Results +++ +++ Anti free radical activity

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Pterocarpus marsupium bark extract +++ +++ Test on Keratinocytes : On the model of UVB induced inflammation against positive control of Aspirin Incubation period of 72 hours Anti-inflammatory effect: Study design I Results

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Pterocarpus marsupium bark extract +++ +++ Test on Polymorphonuclear neutrophilic granulocytes (PMN): On the model of UVB induced inflammation against positive control of Minocyclin Incubation period of 24 hours Anti-inflammatory effect: Study design II Results

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++++ Proven Dandruff Removal

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Piper nigrum fruit extract and Inga alba bark extract +++ +++ Study period of 6 months used once daily against placebo Against Bacterial strains Malassezia globosa and Malassezia furfur , responsible for dandruff, inflammation and irritation Incubation period of 48 hours Anti microbial activity: Study design Incorporated in Root Deep Hydroil Root Deep Shampoo Root Deep Intenso Fluid Results

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Piper nigrum fruit extract and Inga alba bark extract +++ +++ On human keratinocytes on the model of UVB induced inflammation against positive control of Aspirin Incubation period of 48 hours Anti inflammatory activity: Study design Results

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Piper nigrum fruit extract and Inga alba bark extract +++ +++ To evaluate the scalp conditions (dandruff, sebum) against a shampoo with 1% zinc pyrithione , after 4 weeks of treatment and 2 weeks of remanence period Improvement of Scalp properties: Study design

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Results +++ +++ Reduction in Dandruff:

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Results +++ +++ Reduction in Sebum:

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Results +++ +++ Response of Volunteers:

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++++ Proven Shaft strengthening

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Hydrolyzed Pea Protein +++ +++ 17 keratin resembling plant amino acids Improves hair strength lost by damages Restores hair moisture and prevents dry hair Smoothens hair surface Incorporated in Root Deep Shampoo Root Deep Intenso Fluid

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Results +++ +++ Tensile strength measurement:

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Results +++ +++ Cross-section measurement:

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Results +++ +++ Hair moisture measurement:

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Natural is the most over utilized but perhaps the least specified term in personal care creations. Whenever you make a choice of using natural products, the question is "how much nature does it actually hold"? Subtracting the water part, nature score indicates the exact percentage of natural ingredients in your selected B rillare science product. So the next time when you read our score, count your nature proximity & be assured of our constant endeavor to keep you as close as possible-to nature. When it comes to cleaning, sensitive skin/hair possesses the common phenomena of over sensitivity towards traditional cleansers. Let's clean it with sulphate free, biodegradable cleansers. It's your body & it's your world. Stand By The Environment. +++ +++ Personal care cosmetics are formulated with dual purpose of action. One is for the concern specific efficacy and other is for the wellness feel it imparts on human body and soul. Active score is brillare research laboratory's conscious effort to formulate the personal care cosmetics which carries higher percentage of concern specific active ingredients. These active ingredients are carefully combined with organoleptic advancements in cosmetic base. It brings better efficacy, enhanced nourishment and greater cosmetic wellness . The Difference

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+++ +++ The Difference Patented # Anti hair fall and Hair regrowth promoting Nature quantified formulations India first – World first # Patent pending for deep penetrating micro-emulsion techniques of Hydroil & Root Recharge Synergy

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