Career in Bioinformatics : (insight in to the IT Companies) Brijesh Singh Yadav (Senior Research Associate &Head Bioinformatics Research) United Research Center, UIT Campus Allahabad, E-mail: brijeshbioinfo@gmail.com Career in Bioinformatics


What is Bioinformatics? :What is Bioinformatics? Bioinformatics is the application of computer technology and statistics to the management of biological information. In the past decade bioinformatics has become an integral component of research and development in biological sciences. The need for bioinformatics stems from a fundamental change that is taking place in biology.


Bioinformatics Is a Merging of Disciplines :Bioinformatics Is a Merging of Disciplines


Core of Bioinformatics :Core of Bioinformatics TDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLV sequence 3D structure protein functions Properties and evolution of genes, genomes, proteins, metabolic pathways in cells Use of this knowledge for prediction, modelling, and design


Need of bioinformatics :Need of bioinformatics Data growth is exponential Difficult to understand life without BI Detection of new diseases BI tools allow to save expr. Expend. Rational Drug design Computer-aided vaccine design


Need of bioinformatics :Need of bioinformatics


Need of bioinformatics cont… :Need of bioinformatics cont… Handle the growth of information. Knowledge discovery. Globalizing the research. Data visualization.


Need of bioinformatics cont… :Need of bioinformatics cont…


BIOINFORMATICS DEVELOPMENTS IN INDIA :BIOINFORMATICS DEVELOPMENTS IN INDIA Department of Biotechnology created in 1986 Bioinformatics programme started ever since Biotechnology Information System Network (BTISnet) in 1987. BTISnet today has 65 institutions and universities. Emphasis on infrastructure creation and human resource development. Biotechnology in India has greatly benefited from the capacity building in Bioinformatics Dedicated virtual private network connecting the major centres – sharing of data as well as computing resources.


Bioinformatics Facilities in India :Bioinformatics Facilities in India


Educational Activities of India in Bioinformatics :Two forms of initiatives are in operational Two forms of initiatives are in operational Two forms of initiatives are in operational Two forms of initiatives are in operational Short-Term Training Nationwide trainings and workshops Presently around 100 organised per year in seven defined areas More than 10000 trained so far Long-Term Training Advanced Diploma Courses in five universities M.Sc., M.Tech., Ph.D. courses in Bioinformatics Educational Activities of India in Bioinformatics


Integration of Bioinformatics & Biotechnology :Integration of Bioinformatics & Biotechnology Collaborative effort RFP (Request for Proposals) in following areas: Parasitic diseases Agro-biotech Herbal medicine BioPhara Development Clinical Data management


In-house software development :In-house software development GeneScan, GenEvolve, PROCOR PLHOST APSSP (Protein structure prediction), MHCBN PCR: s/w for setting PCR reactions LOOPSEARCH, CONFPLOT VirGen, CE, AVIS Micro array analysis (Avadis), Genome annotation (Acuris), Oligonucleotide probe design (Sarani) BioSuite JNU, Delhi IGIB, Delhi IMTECH, Chandigarh Devi Ahilya University Bose Institute, Kolkatta University of Pune, Pune Strand Genomics, Bangalore TCS, Hyderabad These efforts needs to be strengthened with Human resource development


Bioinformatics Market :Bioinformatics Market Global Bio-Informatics Market –1.2bn In 2004 Overall Market Size Projected to reach USD 1.7 bn by 2006 Indian Bioinformatics Market has touched USD22 Million in 2004 Indian Bioinformatics is growing at the rate of 40% per annum (Source: CII)


Market share of different Segments of Bioinformatics :Market share of different Segments of Bioinformatics Genomic 50% Proteomics 20% Chemoinformatics 19% Pharmacogenomics 15%


Advantages for India :Advantages for India Strong IT capabilities R & D strength in Modern biology Highly trained manpower in biotechnology and Bioinformatics Rich Biodiversity Diverse ethnic population Strong Biotechnology Infrastructure Wide Networking of Institutions and Scientists. Industrial enterprise. HH BIO


Slide 17: The Role of IT in Bioinformatics 1. Electronic Data Capture 2. Data Mining 3. Data Warehousing 4. Data Visualization 5. Customized Software


Indian IT Companies :Indian IT Companies Indian IT companies such as Tata Consultancy Services (TCS), Cognizant Technologies, Infosys, Wipro, and Satyam have already set up their bioinformatics divisions.  TCS, for instance, is entering the bio-informatics market with its indigenously developed computing platforms and applications within this year. The company is nurturing a 40-member team that is working on developing bio-informatics software solutions.


Indian IT Companies Cont.. :Indian IT Companies Cont.. A database application, specially created for the bioinformatics segment is in the pipeline. TCS is also looking at developing bio-informatics software applications in collaboration with biotech and pharma companies.  Satyam's Center of Excellence has identified Data warehousing and Datamining as a key initiative area in the field of bio-informatics since the field is an emerging domain where data warehousing and datamining techniques and concepts are used extensively for deciphering complex patterns and to correlate and analyze the vast volumes of data generated.


Indian Pharma Companies :Indian Pharma Companies Pharmaceutical companies too, are making moves into the bioinformatics arena. GVK Biosciences, Dr. Reddy's Laboratories, Biocon, Astra Zeneca, Ranbaxy, Biological E, and Nicholas Piramal are some of the names that have either opted for the joint venture route or have tied up with start-up companies.


people required by a Industries :people required by a Industries Computer Programmer, who develop software tool and application for biotechnology and life science companies. A good Programmer having knowledge of HTML, XML SAS-CGI CGI between web and database Build HTML page to interface Know DNA analysis programs Understand: Basic Molecular Biology How a network works How databases are structured


People required by a Industries cont.. :People required by a Industries cont.. People with a background in life sciences who are the end user of such programs and packages and they use these tools to translate the information into tangible products such as new molecules, drugs, enzymes etc. They can conduct their R&D program more effectively if they are cross-trained in computing skills. They can also be business analysts for life science companies.


What Is a Bioinformatics Company Like? :What Is a Bioinformatics Company Like? Consists of Biologists, Computer Scientists, Mathematicians and Marketing people. Bioinformatics companies should expect revenues in a few million dollars only. Only those companies who are able to adapt and innovate will survive. A great deal of competition exists in the field. For any new company offering bioinformatics services or products, ‘proof of concept’, will be essential. This means that a nascent company will need to demonstrate its ability before getting business.


Areas of opportunity in India :Areas of opportunity in India Bioinformatics Vaccines, dignostics and therapeutics Biomedical devices, instruments and sensors Bioartificial organs using tissue engineering and stem cells Clinical trial and contract research Agriculuture – disease and pest resistant, drought and salinity tolerant seeds and plants Biofertilisers and Biopesticides


Carrier opportunity available in bioinformatics :Carrier opportunity available in bioinformatics Life Science: Scientific Curator, Gene Analyst, Phylogenitist, Protein Analyst, Research Scientist/Associates Computer Science: Database Programmer,Bio-informatics Software Developer,Nerwork Administrator/Analyst Pharamacuitical Science: Chemoinformatician, Pharmacogenetician, Pharmacogenomics, Research Scientist/Associate Applied Science: Bio-Statistician, Structural Analyst, molecular modeler,


Job opportunities in Bioinformatics :Job opportunities in Bioinformatics Post graduates and ,Doctorates Bachelor degrees / 3 year diploma holders 3) Degree with one year course in computers Qualification Experience Job Title Formal Training and understanding market requirement of Bioinformatics Sound knowledge in Molecular Biology and programming Good typing speed, Knowledge in molecular Biology and computer application Group leaders / Sr. Executives / Scientists/ Faculties System Analyst Technical Asst./ Programmer / COs / DEOs


Major Research Areas in Bioinformatics :Major Research Areas in Bioinformatics


Business Opportunities in BI :Business Opportunities in BI Software development Web servers development Train manpower in Field of BI Database management Rational Drug design Develop Diagnostic kits Assist user in Vaccine development Consultant to Biotech Companies


Outsourcing Model in Technology Businesses :Outsourcing Model in Technology Businesses Outsourcing has developed as an important concept in today's business. 1) Focus on core strength - the opportunity cost of adding a new segment of services to an existing business is high. Companies prefer to not diverge from their focus on their core competencies, and stay competitive. 2) Improve operational efficacy and stay competitive the outsourcing partner can be relied upon to choose the best technology for automation


Outsourcing cont. :Outsourcing cont. 3) Leverage top talents from the bioinformatics companies – companies can make use of the best resources engaged in IT services without having to worry about recruiting, training and retaining professionals  4) Minimize on total cost of ownership – the rate of obsolescence is very high in the IT sector. Companies who outsource do not have to bear the replacement costs that accompany obsolescence.


Outsourcing cont. :Outsourcing cont. 5) Improve service delivery to customers – the company can dictate to the outsourcing partner the timelines it is required to meet. 6) Reduce cost and time – the time spent otherwise on planning and development is saved and better utilized to managing the existing resources. 7) Expand service portfolio – companies can extend their services without having to invest on building in house capabilities


Outsourcing :Outsourcing Inspite of a tremendous increase in demand, the US educational stream has not significantly increased the production of scientific workforce. As a result cost of research has gone higher. Many companies are realizing that they can get their research done abroad, at cheaper cost, without any compromise in quality. In clinical trials for example, GSK (Glaxo smith Kline) has announced that it will shift 30% of its clinical trials to countries like India and China.


Bioinformatics Jobs search engines :Bioinformatics Jobs search engines Medzilla(Biotech,Medical,etc job listings) BioSpace (job listings) BioView (job listings) Bio online Carrier Center Symbios Career Service (Biotech,MedDevice,Pharm ) Genomics ,Bioinformatics and Biocomputing Jumping pills Biotech jobs NEE-HOW Bioresource Finder jobs JobsScience http://www.bhrc.ca/