MORPHOLOGY AND COMPLICATIONS IN DIABETES

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By: umaira (104 month(s) ago)

kindly If you allow me to downlaod this ,shall be very thnakful Regards

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MORPHOLOGY AND COMPLICATIONS IN DIABETES : 

MORPHOLOGY AND COMPLICATIONS IN DIABETES -K.UMESH

Slide 2: 

IMPORTANT MORPHOLOGICAL CHANGES PANCREAS REDUCTION IN SIZE & NUMBER OF ISLET(type 1, particularly in rapidly advancing disease) ISLET ARE SMALL AND INCONSPICUOUS

Slide 3: 

INSULITIS- LEUKOCYTIC INFILTRATION IN THE ISLET PRINCIPALLY COMPOSED OF T LYMPHOCYTES(type 1 lymphocytic infiltration is seen at the time of clinical presentation) DISTRIBUTION IS UNEVEN INSULITIS

Slide 4: 

Β-CELL DEGRANULATION REFLECTS DEPLETION OF STORED INSULIN AMYLOID DEPOSITION- DEPOSITION OF PINK AMORPHOUS MATERIAL IN AND AROUNDCAPILLARIES BETWEEN CELLS. ADVANCE STAGE:ISLETS AREVIRTTULLY OBLITERATED,FIBROSIS MAY B PRESENT.

KIDNEY-DIABETIC NEPHROPATHY : 

KIDNEYS ARE THEPRIMARY TARGET IN DIABETES KIDNEY-DIABETIC NEPHROPATHY THREE LESIONS ARE ENCOUNTERED

Slide 6: 

THE MOST IMPORTANT GLOMERULAR LESIONS ARE: 1)CAPILLARY BASEMENT MEMBRANE THICKENING(starts appearing at almost 2 years of diabetes)

Slide 7: 

2) DIFFUSE MESANGIAL SCLEROSIS THERE IS INCREASE IN MESANGIAL MATRIX ITS DUE TO GBM THICKENING AND MESANGIAL CELL PROLIFERATION MATRIX DEPOSIT ARE PAS POSITIVE

Slide 8: 

3)NODULAR GLOMERULOSCLEROSIS KIMMELSTIEL-WILSON LESION / INTRACAPILLARY GLOMERULOSCLEROSIS LESIONS ARE SMALL ROUND TO OVAL, ENVELOPED,HYALINE,ACELLULAR PRESENT WITHIN THE LOBULES OF GLOMERULI NODULES ARE SURROUNDED BY GLOMERULI CAPILLARY LOOPS WITH THICKENED OR NORMAL GLAMERULAR BASEMENT MENBRANE. NODULES ARE PAS POSITIVE WITH FIBRIN AND LIPID.

HEART AND BLOOD VESSELS : 

HEART AND BLOOD VESSELS THE HALLMARK OF DIABETES IS ACCELERATED ATHEROSCELORIS INVOLVING THE AORTA AND LARGE &MEDIUM SIZED VESSEL. HYALINE ARTERIOLOSCLEROSIS- AMORPHUS HYALINE THICKENING OF WALLS OF ARTERIOLES LEADING TO NARROWING OF LUMEN. DIABETIC MICROANGIOPATHY-DIFFUSE THICKENING OF BASEMENT MEMBRANES LIKE CAPILLARIES OF SKIN,SKELETAL MUSCLE,RETINA,RENAL GLOMERULI & RENAL MEDULA.NON VASCULAR STRUCTURES SUCH AS RENAL TUBULES,BOWMAN CAPSULE,PERIPHERAL NERVE & PLACENTA

EYE : 

EYE DIABETIC RETINOPATHY BASEMENT MENBRANE OF RETINAL BLOOD VESSELE IS THICKENED

Slide 11: 

CENTRAL AND PERIPHERAL NERVOUS SYSTEM DIABETIC NEUROPATHY & AUTONOMIC SYSFUNCTION DEMYLENATION, SCHWANN CELL INJURY & AXONAL DAMAGE

COMPLICATIONS : 

COMPLICATIONS

ACUTE METABOLIC COMOLICATION : 

ACUTE METABOLIC COMOLICATION

LATE SYSTEMIC COMPLICATION : 

LATE SYSTEMIC COMPLICATION

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