logging in or signing up Haematopoiesis II bashirbashir Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 356 Category: Education License: All Rights Reserved Like it (1) Dislike it (0) Added: September 15, 2012 This Presentation is Public Favorites: 2 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript Haematopoiesis II: Haematopoiesis II Presented by : Bashir A. Bashir Mohamed, MS.c 2012PowerPoint Presentation: Hematopoietic Response hypoxia RBC infection granulocyte/monocyte antigen lymphocyte hemorrhage plateletLeukopoiesis: Leukopoiesis Leucopoiesis is hormonally stimulated by two families of cytokines (hematopoietic factors) – interleukins and colony-stimulating factors (CSFs) Interleukins are numbered (e.g., IL-1, IL-2), whereas CSFs are named for the WBCs they stimulate (e.g., granulocyte-CSF stimulates granulocytes)Leukopoiesis: Macrophages and T cells are the most important sources of cytokines Many hematopoietic hormones are used clinically to stimulate bone marrow Leukopoiesis Formation of Leukocytes : Formation of Leukocytes All leukocytes originate from Pluri - stem cell Pluripotential stem cell differentiate into myeloid stem cells and lymphoid stem cells Myeloid stem cells become myeloblasts or monoblasts Formation of Leukocytes : Lymphoid stem cells become lymphoblasts Myeloblasts develop into eosinophils , neutrophils , and basophils Monoblasts develop into monocytes Lymphoblasts develop into lymphocytes Formation of LeukocytesFormation of Leukocytes: Formation of LeukocytesFormation of Granulopoiesis: Formation of GranulopoiesisPowerPoint Presentation: Myeloblasts become all of the granular leukocytes Monoblasts become monocytes Lymphoblasts become lymphocytes. Granulopoiesis : Granulopoiesis Precursors Myeloblast <4% Pro myelocytes Myelocytes Metamyelocytes Band form (stab form) Monopoiesis : Monopoiesis Stem cell Monoblast Promonocyte Monocyte Diameter 15 – 18 µm Have a large nucleus horse shoe shape Cytoplasm abundant gray-blue color It may contain vacuoles Occasionally have a reddish blue granulesPowerPoint Presentation: Caricature of Professor Metchnikoff Lymphopoiesis : Lymphopoiesis Immunologically competent cells Primary lymphoid organs Bone marrow Thymus Secondary lymphoid organs Lymph nodes Spleen Lymphoid tissuesLymphopoiesis: Lymphopoiesis Lymphocytes B and T lymphocytes NK killer cellsThrombopoiesis: Thrombopoiesis The stem cell for platelets is the hemocytoblast The sequential developmental pathway is hemocytoblast, megakaryoblast, promegakaryocyte, megakaryocyte, and plateletsPowerPoint Presentation: Pluripotent stem cell megakaryoblast promegakaryocyte megakaryocyte platelets Sequential access of mechanism Thrombopoiesis : Thrombopoiesis Platelet play a major role in primary hemostasis Life span 7-10 days Production, fragmentation of cytoplasm Megakaryocytes undergoes endomitotic division 1/3 in spleenMegakaryocyte: Megakaryocyte Diameter 30 – 100 µm Largest cell found in the bone marrow Cytoplasm fully by platelets Normal B.M contain 1 – 2 megakaryocyte / hpf Functionally two type: A- platelet producing B- Non platelet producingActive megakaryocytes: Active megakaryocytesNormal Platelets: Normal PlateletsLifespan of blood cells: Lifespan of blood cells RBC 120 days platelet 10 days granulocytes circ : 9 hours tissue : days lymphocyte circ : variable (hours to years) tissue : weeks to years Summary : Summary Normal haemopoiesis is necessary for the survival It is under the control of multiple factors Normal bone marrow environment is necessary for normal haemopoiesis Decreased production results in cytopeniasPowerPoint Presentation: THANX You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.