Outline :
Outline In Vivo Techniques for Studying the Oral Mucosal Absorption.
In Vitro Methods for Measuring Permeability of the Oral Mucosa.
Nasal drug delivery system.
Pulmonary drug delivery system.
In Vivo Techniques for Studying the Oral Mucosal Absorption. :
In Vivo Techniques for Studying the Oral Mucosal Absorption. knowledge of the absorption characteristics of the drug are important since, in both cases, it needs to be taken up by the oral mucosa.
In the case of local delivery , knowledge of how long the drug remains in the mucosa following uptake is an important.
In the case of systemic delivery the amount of drug crossing the oral mucosa and entering the blood is an important.
A. ANIMAL TECHNIQUES
Animal models such as the dog, cat , rabbit, hamster, rat, and sheep have been used to determine the oral mucosal absorption characteristics of drugs.
The methodologies used can broadly be categorized into
Application of dosage forms
Absorption cells
Perfusion cells.