ESTROGEN

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Oleh : M. Hamsah Pembimbing : Dr. dr. Hj . A. Mardiah Tahir , SpOG Estrogen

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Greek

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Struktur dan produksi dari estrogen

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>

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tempat sintesis hormon estrogen.

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Endocrine Control of the Ovarian Cycle

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Ovarian synthesis of estrogen Binding to sex hormone– binding globulin and albumin in blood 17 b -Estradiol Sex hormone–binding globulin albumin disasosias i Degradasi Estrogen 2-Hydroxyestrogens 16 a -Hydroxyestrogens Catechol O- methyltransferase Methoxylated estrogens Estrogen bebas Hidrolisis Estrogen reseptor Estrogen reseptor kompleks Akumulasi lipoidal Estrogen di jaringan lemak Lipoidal Estrogen Sintesis ester lemak estrogen di darah ovarium Sintesis, transpor, dan metabolisme estrogen

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Estrogen

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tiga sediaan estrogen

Pre-Menopause:

Pre-Menopause 17 OVARY Testosterone Estradiol Estrone Estriol Progesterone aromatase

Post Menopause :

Post Menopause 18 ADRENAL GLAND Testosterone Estradiol Estrone Estriol Cortisol Dehydroepiandrosterone (DHEA) Androstenedione aromatase aromatase

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Estradiol

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Effects

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Therapy

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List of estradiol medications Oral versions : Estrace ® , Activella ® , Progynova ® , estrofem ® Transdermal preparation : Alora ® , Climara ® , Vivelle ® , Menostar ® , Estraderm TTS ® Ointments : Estrasorb Topical ® , Estrogel ® Injection : Lunelle ® monthly injection Vaginal ointment : Estrace Vaginal Cream ® , Premarin Cream ® Vaginal ring : Estring ® Conjugated estrogen preparations : Premarin ® .

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Estrone

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Estriol

Factors Influencing Parturition:

Factors Influencing Parturition

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Milk production is prevented during pregnancy by estrogen stimulation of PIH

Lactation::

Lactation: Function of prolactin: prolactin Promotes the secretion of milk Estrogen and progesterone Birth Decrease [estrogen + progesterone Increase lactogenic effect (prolactin) Increase [milk] in the alveoli of the Breast – not the ducts!!!!!

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41 THANK YOU estrogen Women have reason to say