logging in or signing up Nanoparticles and Carbon Nano Tubes ankush85 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 6499 Category: Science & Tech.. License: All Rights Reserved Like it (10) Dislike it (0) Added: November 22, 2009 This Presentation is Public Favorites: 2 Presentation Description No description available. Comments Posting comment... By: borane (7 month(s) ago) A nice presentation that exposes all the unthinkable sources of nano particles. Great job. Pls, I will like you to send a copy of the presentation to my mail address (mailwale32@yahoo.com). Thank you for the information. Saving..... Post Reply Close Saving..... 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See all Premium member Presentation Transcript Particles:Nanoparticles, Fullerenes and Carbon Nano Tubes : Particles:Nanoparticles, Fullerenes and Carbon Nano Tubes Ankush Bagga Topics of the Workshop : Topics of the Workshop « Environmental Aspects » – latest research activities « Material Safety Standards » - required for safety of producers and consumers nearly or insoluble particles Slide 3: Properties of Nanoparticles (< 100 nm) Aerosol formation processes: Heterogeneous + homogeneous nucleation Combustion, photochemical reactions; etc. Growth by coagulation, shrinkage Chemical formation processes: Polymerization (Emulsion) Precipitation, Crystallization Growth by coagulation, shrinkage After: Wolfgang G. Kreyling, GSF – Forschungszentrum für Umwelt und Gesundheit, München Slide 4: Current and Emerging Applications for Nanoparticles Investors, Industrials, Scientists : Investors, Industrials, Scientists U.S. venture capital firm Draper Fisher Jurvetson: „It would not invest in a nanotech business unless the products had already been proven safe“. Germany-based Munich Re Group: „Up to now, losses involving dangerous products were on a relatively manageable scale, whereas, taken to extremes, nanotechnology products can even cause ecological damage which is difficult to contain” . Patricia Pineau, a L’Oreal research adviser: “At each step of the product development – from the raw materials to the final formula – we evaluate the safety in vitro and then, only if the previous test is negative, in vivo on human volunteers” . Ken Donaldson of the University of Edinburgh Medical School: „A new way of classifying nano-particles needs to be created, that takes more than size into account, but also the “full spectrum of toxicities“ that might arise from nanoparticles of different compositions“. http://www.smalltimes.com/document_display.cfm?document_id=7608 Slide 6: Regulation Currently, dosage of particles for regulation purposes is defined by mass per unit volume, however this does not take into account particle size. Hence it is clear that agglomeration, particle size and surface reactivity will now have to be taken into account when deciding the regulation of nanoparticles. The point was made however that there are many types of nanoparticles and that they should not be treated as a general case when deciding regulation. To resolve this issue, further toxicological studies must be performed in order to effectively inform regulators. The point was also made that regulations may differ between locales e.g. in the USA sun creams are categorised as drugs for regulation, while in the UK they are regulated as cosmetics. Nanotechnology: views of Scientists and Engineers Report of a workshop held as part of the Nanotechnology study (http://www.nanotec.org.uk/) Slide 7: Insoluble or nearly insoluble nano- or ultrafine particles Research for developing standards together with industry Example 3R Foundation – reducing animal experiments Summary Summary : Summary Define the hot spots of danger coming from nanoparticles – risk assessment Road map – amount of particles on the market, exposure, uptake Road map for particles in research – nanotubes, CdSe etc. Develop models (in-vitro and in-vivo) for interaction with the human body toxicity, biodistribution, allergies Summary : Life Cycle assessment for chemicals adapted to nanoparticles Define component by nanoparticle relevant features Summary Summary : Summary Further detailed recommendation Need more information from responsibles in industry and related researchers, toxicologists, risk assessment Workshop SVMT-SATW-TOP NANO 21 on « Safety aspects of nanoparticles » November 2004 Particles : Particles Ultrafine- or nanoparticles, colloids, aerosols are smaller than 100 nm. In comparison with their source materials, such nanoparticles have different optical, electrical, mechanical, and chemical properties. They are not only unique to this field of hi-tech; they are present in our everyday lives and at various conventional workplaces. After BIA-Report 7/2003 Nanoparticle Application 2003 : Nanoparticle Application 2003 Established commercial nanoparticle applications Tires, Other Rubber Products Catalytic Converters Photographic Supplies Inks and Pigments Coatings and Adhesives Ultrafine Polishing Compounds UV Absorbers for Sun Screens Synthetic Bone Ferrofluids Optical Fiber Cladding Launch-Phase Nanoparticle Applications Fabrics and Fabric Treatments Filtration Systems Dental Products Surface Disinfectants Diesel Fuel Additives Fuel and Explosive Additives Hazardous Chemical Neutralizers Developmental Nanoparticle Applications Recharg. Lithium Ion Batteries Antioxidants Dental-Care Products http://www.mindbranch.com Nanotube Application 2003 : Nanotube Application 2003 Commercial Nanotube Applications Automotive Components Electronics Production/Clean-Room Equipment Scanning Microscope Tips Sports Equipment Launch-Phase Nanotube Applications Field Emission Devices X-Ray Devices Flat-Panel Displays Other Field Emission Applications Developmental Nanotube Applications Semiconductors Drug-Delivery Systems Fuel Cells http://www.mindbranch.com Field of Concern in the Environment : Field of Concern in the Environment Behaviour and influence of nanoparticles in the biota? Nanoparticles may influence the biosphere Structural transition by liquids like water (biogenic nanoparticles) Chemical/physical transition by recycling (combustion) Behaviour and influence of nanoparticles in the food chain? Filter-feeding organisms such as plankton regulate the intake and distribution of these nanoparticles? Further uptake by fishes, birds, large animals Biodistribution of nanoparticles in the body? Lung, liver, blood, etc. Manipulation of of cells and/or genes by nanoparticles? Transfection Formation/initiation of tumour cells Misfunction of proteins after adsorption Slide 15: Lung Smoking, diesel soot, tires, rubber products Smoke and exhaust of welding, soldering, foundaries, injection molding, grinding and polishing Nanoparticles based ceramics, quantum dots Nanoparticles based medical products (aerosols) Skin Cosmetics, pharmaceutics, paintings Intravenious, intraarticular, systemic Drugs, diagnostic agents, food Way of assimilation and incorporation Way of assimilation and incorporation : Modes of action and mechnisms Lymphatic system Blood system Nervous systems Cells - cell interaction Uptake in the cells and the nucleus Way of assimilation and incorporation Material Safety Standards : Material Safety Standards No standards exist for nanoparticles FDA list “Generally Recognized As Safe” (GRAS) – applicable to nanosized particles? MAK not applicable for nanoparticles? In-vivo-solubility of nanoparticles – no method Nanopathology ? Slide 18: Classical tests not sufficiently specific and not adequate for a comprehensive risk assessment of multiple interactions of NP with biological systems After W. G. Kreyling, GSF - Forschungszentrum für Umwelt und Gesundheit, Institut für Inhalationsbiologie, Neuherberg Material Standards : Material Standards Physical standards for surface roughness, subsurface properties, form (flatness, sphericity, asphericity) glass, ceramics and metals are urgently needed. Besides those standards, made of anorganic materials, equivalent standards are very desired for nanotechnology in all kind of processes (manufacture, monitoring, measurement) of organic materials including living cells in special cases. Position paper on „The need for measurement and testing in nanotechnology“ Compiled by the High Level Expert Group on Measurement and Testing, Under the European Framework Programme for Research and Development 2002 - HLEG_nanotech_full_final_11/3/02 Analytic Aspects : Analytic Aspects Analytics (measurement and test engineering) – air, surface, liquid, body Particle concentration Particles size and form, particle agglomerates Particle surface charge, coating after synthesis, within the environment Dissolution and recombination Safety Aspects : Safety Aspects Production New technologies, new particle formulation Production in clean rooms? Filter? Health aspects of employees? Classic production routes Learn from already existing safety standards? Safety Aspects : Safety Aspects Environment Functionalized particles Influence on biota: internalization of particles Influence on the biosphere Nanoparticles in a matrix Recycling, waste/material combustion Pollution, smoke, dust Reduced size and size distribution, higher internalization Safety Aspects : Safety Aspects Public Health Overall air pollution (e.g. cigarettes, diesel soot, tires, industrial contamination) How far does nanotechnology boost danger? Need for more epidemiologic research? Daily life body exposure (cosmetics, paint, clothing, nutrition) Information of customers? Future requirements for industry? Challenges and requirements for research (medical, basic, engineering) Future tailored particles (e.g. in life sciences, transport, etc.) Challenges and requirements for research (medical, basic, enginering) Support and requirements for industry? Information of customers? Slide 25: Properties of Nanoparticles to be determined Chemistry Surface chemistry, surface charge Combination of elements (transition metals) Dissolution and recombination Adsorption, desorption, catalytic activity …. Physics (Quantum) size and form effect Volume - Surface properties Transport ….. Biology Uptake: histospecific, cellular, subcellular (nucleus) Blood compatibility, rheological effects ….. Slide 26: Exposure During manufacturing + processing at the workplace Single nanoparticle product (aerosol, colloid) Concentration (air, skin) Exposure periods assessable General population + population during use + application Multiple products at low concentrations (exhaust, cosmetics, medical products) Undefined exposure periods and concentration Material Safety Standards RISK = HAZARD + EXPOSURE (ASSESSMENT) : RISK = HAZARD + EXPOSURE (ASSESSMENT) Too often, the ‘exposure’ part of this equation is omitted and hazard is equated with risk. This is an important oversight because there can be little risk to even hazardous materials provided there is no exposure. Thus, the exposure component of the risk equation is vital. Example: recent toxicity studies have demonstrated that high-dose, intratracheally-instilled, single walled carbon nanotubes in the lungs of rats may produce unusual foreign-body tissue reactions. Physiological relevance: occupational exposure assessment studies have indicated that aerosol exposure levels of carbon nanotubes in the workplace were, in this case, negligible. After David B. Warheit in Materialstoday February 2004 Translocation of Nanoparticles : Translocation of Nanoparticles After W. G. Kreyling, GSF - Forschungszentrum für Umwelt und Gesundheit, Institut für Inhalationsbiologie, Neuherberg Slide 29: After David B. Warheit in Materialstoday February 2004 Translocation of Nanoparticles Ten Toxic Warnings : Ten Toxic Warnings 1997 - Titanium dioxide/zinc oxide nanoparticles from sunscreen are found to cause free radicals in skin cells, damaging DNA. (Oxford University and Montreal University) Dunford, Salinaro et al. March 2002 – „… engineered nanoparticles accumulate in the organs of lab animals and are taken up by cells…“ Dr. Mark Wiesner March 2003 - „.. studies on effects of nanotubes on the lungs of rats produced more toxic response than quartz dust.“ „Scientists from DuPont Haskell laboratory present varying but still worrying findings on nanotube toxicity. Nanotubes can be highly toxic." - Dr. Robert Hunter (NASA researcher) March 2003 - Dr. Howard: the smaller the particle, the higher its likely toxicity and that nanoparticles have various routes into the body and across membranes such as the blood brain barrier. ETC Group July 2003 - Nature reports on work by CBEN scientist Mason Tomson that shows buckyballs can travel unhindered through the soil. "Unpublished studies by the team show that the nanoparticles could easily be absorbed by earthworms, possibly allowing them to move up the food-chain and reach humans" - Dr. Vicki Colvin, the Center's director. http://online.sfsu.edu/~rone/Nanotech/nanobraindamage.htm Ten Toxic Warnings : Ten Toxic Warnings January 2004 - Dr. Günter Oberdörster: nanoparticles are able to move easily from the nasal passageway to the brain. January 2004 - Nanosafety researchers from University of Leuven, Belgium in Nature: nanoparticles will require new toxicity tests: "We consider that producers of nanomaterials have a duty to provide relevant toxicity test results for any new material, according to prevailing international guidelines on risk assessment. Peter H. M. Hoet, Abderrrahim Nemmar and Benoit Nemery, University of Belgium(14) January 2004 - Nanotox 2004: Dr. Vyvyan Howard presents initial findings that gold nanoparticles can move across the placenta from mother to fetus. February 2004 - Scientists at University of California, San Diego discover that cadmium selenide nanoparticles (quantum dots) can break down in the human body potentially causing cadmium poisoning. "This is probably something the [research] community doesn't want to hear." - Mike Sailor, UC San Diego.(16) March 2004 - Dr. Eva Oberdörster: buckyballs (fullerenes) cause brain damage in juvenile fish along with changes in gene function. "Given the rapid onset of brain damage, it is important to further test and assess the risks and benefits of this new technology before use becomes even more widespread." - Dr. Eva Oberdörster. http://online.sfsu.edu/~rone/Nanotech/nanobraindamage.htm Slide 32: Exposure to nanoparticles Smoking, diesel soot, tires, rubber products Smoke and exhaust of welding, soldering, foundaries, injection molding, grinding and polishing Nanoparticles based ceramics, quantum dots Nanoparticles based medical products (aerosols) Cosmetics, pharmaceutics, paintings Drugs, diagnostic agents, food Material Safety Standards You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
Nanoparticles and Carbon Nano Tubes ankush85 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 6499 Category: Science & Tech.. License: All Rights Reserved Like it (10) Dislike it (0) Added: November 22, 2009 This Presentation is Public Favorites: 2 Presentation Description No description available. Comments Posting comment... By: borane (7 month(s) ago) A nice presentation that exposes all the unthinkable sources of nano particles. Great job. Pls, I will like you to send a copy of the presentation to my mail address (mailwale32@yahoo.com). Thank you for the information. Saving..... Post Reply Close Saving..... Edit Comment Close By: shwetarawal (8 month(s) ago) nice presentation.sir ple allow me download.my email is shweta_rawal111@rediffmail.com.thank u so much sir. Saving..... Post Reply Close Saving..... Edit Comment Close By: maydayya (10 month(s) ago) thx Saving..... Post Reply Close Saving..... Edit Comment Close By: veenabk (14 month(s) ago) presentation is brilliant pls allow me to download Saving..... Post Reply Close Saving..... Edit Comment Close By: gcmohan (14 month(s) ago) The presentaion is good. Kindly allow me to down load. G.Chandramohan Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Particles:Nanoparticles, Fullerenes and Carbon Nano Tubes : Particles:Nanoparticles, Fullerenes and Carbon Nano Tubes Ankush Bagga Topics of the Workshop : Topics of the Workshop « Environmental Aspects » – latest research activities « Material Safety Standards » - required for safety of producers and consumers nearly or insoluble particles Slide 3: Properties of Nanoparticles (< 100 nm) Aerosol formation processes: Heterogeneous + homogeneous nucleation Combustion, photochemical reactions; etc. Growth by coagulation, shrinkage Chemical formation processes: Polymerization (Emulsion) Precipitation, Crystallization Growth by coagulation, shrinkage After: Wolfgang G. Kreyling, GSF – Forschungszentrum für Umwelt und Gesundheit, München Slide 4: Current and Emerging Applications for Nanoparticles Investors, Industrials, Scientists : Investors, Industrials, Scientists U.S. venture capital firm Draper Fisher Jurvetson: „It would not invest in a nanotech business unless the products had already been proven safe“. Germany-based Munich Re Group: „Up to now, losses involving dangerous products were on a relatively manageable scale, whereas, taken to extremes, nanotechnology products can even cause ecological damage which is difficult to contain” . Patricia Pineau, a L’Oreal research adviser: “At each step of the product development – from the raw materials to the final formula – we evaluate the safety in vitro and then, only if the previous test is negative, in vivo on human volunteers” . Ken Donaldson of the University of Edinburgh Medical School: „A new way of classifying nano-particles needs to be created, that takes more than size into account, but also the “full spectrum of toxicities“ that might arise from nanoparticles of different compositions“. http://www.smalltimes.com/document_display.cfm?document_id=7608 Slide 6: Regulation Currently, dosage of particles for regulation purposes is defined by mass per unit volume, however this does not take into account particle size. Hence it is clear that agglomeration, particle size and surface reactivity will now have to be taken into account when deciding the regulation of nanoparticles. The point was made however that there are many types of nanoparticles and that they should not be treated as a general case when deciding regulation. To resolve this issue, further toxicological studies must be performed in order to effectively inform regulators. The point was also made that regulations may differ between locales e.g. in the USA sun creams are categorised as drugs for regulation, while in the UK they are regulated as cosmetics. Nanotechnology: views of Scientists and Engineers Report of a workshop held as part of the Nanotechnology study (http://www.nanotec.org.uk/) Slide 7: Insoluble or nearly insoluble nano- or ultrafine particles Research for developing standards together with industry Example 3R Foundation – reducing animal experiments Summary Summary : Summary Define the hot spots of danger coming from nanoparticles – risk assessment Road map – amount of particles on the market, exposure, uptake Road map for particles in research – nanotubes, CdSe etc. Develop models (in-vitro and in-vivo) for interaction with the human body toxicity, biodistribution, allergies Summary : Life Cycle assessment for chemicals adapted to nanoparticles Define component by nanoparticle relevant features Summary Summary : Summary Further detailed recommendation Need more information from responsibles in industry and related researchers, toxicologists, risk assessment Workshop SVMT-SATW-TOP NANO 21 on « Safety aspects of nanoparticles » November 2004 Particles : Particles Ultrafine- or nanoparticles, colloids, aerosols are smaller than 100 nm. In comparison with their source materials, such nanoparticles have different optical, electrical, mechanical, and chemical properties. They are not only unique to this field of hi-tech; they are present in our everyday lives and at various conventional workplaces. After BIA-Report 7/2003 Nanoparticle Application 2003 : Nanoparticle Application 2003 Established commercial nanoparticle applications Tires, Other Rubber Products Catalytic Converters Photographic Supplies Inks and Pigments Coatings and Adhesives Ultrafine Polishing Compounds UV Absorbers for Sun Screens Synthetic Bone Ferrofluids Optical Fiber Cladding Launch-Phase Nanoparticle Applications Fabrics and Fabric Treatments Filtration Systems Dental Products Surface Disinfectants Diesel Fuel Additives Fuel and Explosive Additives Hazardous Chemical Neutralizers Developmental Nanoparticle Applications Recharg. Lithium Ion Batteries Antioxidants Dental-Care Products http://www.mindbranch.com Nanotube Application 2003 : Nanotube Application 2003 Commercial Nanotube Applications Automotive Components Electronics Production/Clean-Room Equipment Scanning Microscope Tips Sports Equipment Launch-Phase Nanotube Applications Field Emission Devices X-Ray Devices Flat-Panel Displays Other Field Emission Applications Developmental Nanotube Applications Semiconductors Drug-Delivery Systems Fuel Cells http://www.mindbranch.com Field of Concern in the Environment : Field of Concern in the Environment Behaviour and influence of nanoparticles in the biota? Nanoparticles may influence the biosphere Structural transition by liquids like water (biogenic nanoparticles) Chemical/physical transition by recycling (combustion) Behaviour and influence of nanoparticles in the food chain? Filter-feeding organisms such as plankton regulate the intake and distribution of these nanoparticles? Further uptake by fishes, birds, large animals Biodistribution of nanoparticles in the body? Lung, liver, blood, etc. Manipulation of of cells and/or genes by nanoparticles? Transfection Formation/initiation of tumour cells Misfunction of proteins after adsorption Slide 15: Lung Smoking, diesel soot, tires, rubber products Smoke and exhaust of welding, soldering, foundaries, injection molding, grinding and polishing Nanoparticles based ceramics, quantum dots Nanoparticles based medical products (aerosols) Skin Cosmetics, pharmaceutics, paintings Intravenious, intraarticular, systemic Drugs, diagnostic agents, food Way of assimilation and incorporation Way of assimilation and incorporation : Modes of action and mechnisms Lymphatic system Blood system Nervous systems Cells - cell interaction Uptake in the cells and the nucleus Way of assimilation and incorporation Material Safety Standards : Material Safety Standards No standards exist for nanoparticles FDA list “Generally Recognized As Safe” (GRAS) – applicable to nanosized particles? MAK not applicable for nanoparticles? In-vivo-solubility of nanoparticles – no method Nanopathology ? Slide 18: Classical tests not sufficiently specific and not adequate for a comprehensive risk assessment of multiple interactions of NP with biological systems After W. G. Kreyling, GSF - Forschungszentrum für Umwelt und Gesundheit, Institut für Inhalationsbiologie, Neuherberg Material Standards : Material Standards Physical standards for surface roughness, subsurface properties, form (flatness, sphericity, asphericity) glass, ceramics and metals are urgently needed. Besides those standards, made of anorganic materials, equivalent standards are very desired for nanotechnology in all kind of processes (manufacture, monitoring, measurement) of organic materials including living cells in special cases. Position paper on „The need for measurement and testing in nanotechnology“ Compiled by the High Level Expert Group on Measurement and Testing, Under the European Framework Programme for Research and Development 2002 - HLEG_nanotech_full_final_11/3/02 Analytic Aspects : Analytic Aspects Analytics (measurement and test engineering) – air, surface, liquid, body Particle concentration Particles size and form, particle agglomerates Particle surface charge, coating after synthesis, within the environment Dissolution and recombination Safety Aspects : Safety Aspects Production New technologies, new particle formulation Production in clean rooms? Filter? Health aspects of employees? Classic production routes Learn from already existing safety standards? Safety Aspects : Safety Aspects Environment Functionalized particles Influence on biota: internalization of particles Influence on the biosphere Nanoparticles in a matrix Recycling, waste/material combustion Pollution, smoke, dust Reduced size and size distribution, higher internalization Safety Aspects : Safety Aspects Public Health Overall air pollution (e.g. cigarettes, diesel soot, tires, industrial contamination) How far does nanotechnology boost danger? Need for more epidemiologic research? Daily life body exposure (cosmetics, paint, clothing, nutrition) Information of customers? Future requirements for industry? Challenges and requirements for research (medical, basic, engineering) Future tailored particles (e.g. in life sciences, transport, etc.) Challenges and requirements for research (medical, basic, enginering) Support and requirements for industry? Information of customers? Slide 25: Properties of Nanoparticles to be determined Chemistry Surface chemistry, surface charge Combination of elements (transition metals) Dissolution and recombination Adsorption, desorption, catalytic activity …. Physics (Quantum) size and form effect Volume - Surface properties Transport ….. Biology Uptake: histospecific, cellular, subcellular (nucleus) Blood compatibility, rheological effects ….. Slide 26: Exposure During manufacturing + processing at the workplace Single nanoparticle product (aerosol, colloid) Concentration (air, skin) Exposure periods assessable General population + population during use + application Multiple products at low concentrations (exhaust, cosmetics, medical products) Undefined exposure periods and concentration Material Safety Standards RISK = HAZARD + EXPOSURE (ASSESSMENT) : RISK = HAZARD + EXPOSURE (ASSESSMENT) Too often, the ‘exposure’ part of this equation is omitted and hazard is equated with risk. This is an important oversight because there can be little risk to even hazardous materials provided there is no exposure. Thus, the exposure component of the risk equation is vital. Example: recent toxicity studies have demonstrated that high-dose, intratracheally-instilled, single walled carbon nanotubes in the lungs of rats may produce unusual foreign-body tissue reactions. Physiological relevance: occupational exposure assessment studies have indicated that aerosol exposure levels of carbon nanotubes in the workplace were, in this case, negligible. After David B. Warheit in Materialstoday February 2004 Translocation of Nanoparticles : Translocation of Nanoparticles After W. G. Kreyling, GSF - Forschungszentrum für Umwelt und Gesundheit, Institut für Inhalationsbiologie, Neuherberg Slide 29: After David B. Warheit in Materialstoday February 2004 Translocation of Nanoparticles Ten Toxic Warnings : Ten Toxic Warnings 1997 - Titanium dioxide/zinc oxide nanoparticles from sunscreen are found to cause free radicals in skin cells, damaging DNA. (Oxford University and Montreal University) Dunford, Salinaro et al. March 2002 – „… engineered nanoparticles accumulate in the organs of lab animals and are taken up by cells…“ Dr. Mark Wiesner March 2003 - „.. studies on effects of nanotubes on the lungs of rats produced more toxic response than quartz dust.“ „Scientists from DuPont Haskell laboratory present varying but still worrying findings on nanotube toxicity. Nanotubes can be highly toxic." - Dr. Robert Hunter (NASA researcher) March 2003 - Dr. Howard: the smaller the particle, the higher its likely toxicity and that nanoparticles have various routes into the body and across membranes such as the blood brain barrier. ETC Group July 2003 - Nature reports on work by CBEN scientist Mason Tomson that shows buckyballs can travel unhindered through the soil. "Unpublished studies by the team show that the nanoparticles could easily be absorbed by earthworms, possibly allowing them to move up the food-chain and reach humans" - Dr. Vicki Colvin, the Center's director. http://online.sfsu.edu/~rone/Nanotech/nanobraindamage.htm Ten Toxic Warnings : Ten Toxic Warnings January 2004 - Dr. Günter Oberdörster: nanoparticles are able to move easily from the nasal passageway to the brain. January 2004 - Nanosafety researchers from University of Leuven, Belgium in Nature: nanoparticles will require new toxicity tests: "We consider that producers of nanomaterials have a duty to provide relevant toxicity test results for any new material, according to prevailing international guidelines on risk assessment. Peter H. M. Hoet, Abderrrahim Nemmar and Benoit Nemery, University of Belgium(14) January 2004 - Nanotox 2004: Dr. Vyvyan Howard presents initial findings that gold nanoparticles can move across the placenta from mother to fetus. February 2004 - Scientists at University of California, San Diego discover that cadmium selenide nanoparticles (quantum dots) can break down in the human body potentially causing cadmium poisoning. "This is probably something the [research] community doesn't want to hear." - Mike Sailor, UC San Diego.(16) March 2004 - Dr. Eva Oberdörster: buckyballs (fullerenes) cause brain damage in juvenile fish along with changes in gene function. "Given the rapid onset of brain damage, it is important to further test and assess the risks and benefits of this new technology before use becomes even more widespread." - Dr. Eva Oberdörster. http://online.sfsu.edu/~rone/Nanotech/nanobraindamage.htm Slide 32: Exposure to nanoparticles Smoking, diesel soot, tires, rubber products Smoke and exhaust of welding, soldering, foundaries, injection molding, grinding and polishing Nanoparticles based ceramics, quantum dots Nanoparticles based medical products (aerosols) Cosmetics, pharmaceutics, paintings Drugs, diagnostic agents, food Material Safety Standards