Mucoadhesive drug delivery system

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prepared by ANISH from APC

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By: MALLAVIJAY (114 month(s) ago)

can u plz send ths PPT to naresh.yechuri@gmail.com

By: anish008kumar (114 month(s) ago)

dear u can download this ppt directly.....bt if u face problem to download it then i will send this ppt.....,,,,,,,ok?

 

Presentation Transcript

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Presentation On MUCOADHESIVE DRUG DELIVERY SYSTEM Submitted By: Anish Kumar Saini B.Pharma Final Year Submitted To: Miss Neeta Choudhary M.Pharma, Ph.D.* ALWAR PHARMACY COLLEGE Email i.d.- anish008kumar@gmail.com Alwar (Rajasthan)

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Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. DEFINITION Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application, providing a controlled rate of drug release for improved therapeutic outcome.

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Bioadhesion and Mucoadhesion Bioadhesion is defined as an ability of a material to adhere to a biological tissue for an extended period of time. In the case of polymer attached to the mucin layer of a mucosal tissue, the term mucoadhesion´  is used.

MECHANISM OF MUCOADHESION :

MECHANISM OF MUCOADHESION Before discussing about the mechanism of muco-adhesion we must know about the composition of mucous briefly. Mucus is composed mainly of Water (>95%) Glycoprotein of exceptionally high molecular weight Mineral salts -1 % Free proteins – 0.5 to 1%

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Theories of Mucoadhesion There are five main theories can be distinguished as : 1. Wetting Theory of Mucoadhesion 2. Electrostatic Theory of Mucoadhesion 3. Diffusion Theory of Mucoadhesion 4. Adsorption Theory of Mucoadhesion 5. Fracture Theory of Adhesion

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1. Wetting Theory of Mucoadhesion It explains adhesion as an embedding process, whereby adhesive agents penetrate into surface irregularities of the substrate and ultimately harden, producing many adhesive anchors. Free movement of the adhesive on the surface of the substrate means that it must overcome any surface tension effects present at the interface. The wetting theory calculates the contact angle and the thermodynamic work of adhesion.

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2. Electrostatic Theory of Mucoadhesion According to electrostatic theory, transfer of electrons occurs across the adhesive interface and adhering surface. This results in the establishment of the electrical double layer at the interface and a series of attractive forces responsible for maintaining contact between the two layers. 3. Diffusion Theory of Mucoadhesion Diffusion theory describes that polymeric chains from the bioadhesive interpenetrate into glycoprotein mucin chains and reach a sufficient depth within the opposite matrix to allow formation of a semipermanent bond.

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4. Adsorption Theory of Mucoadhesion According to the adsorption theory, after an initial contact between two surfaces, the materials adhere because of surface forces acting between the chemical structures at the two surfaces. 5. Fracture Theory of Adhesion This theory describes the force required for the separation of two surfaces after adhesion.

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Polymer in mucosal drug delivery system 1. Hydrophilic polymers 2. Hydrogels 3. Thiolated polymers 4. Lectin-based polymers

Polymers:

Polymers The following are the polymers their relative bio adhesive property Polymer Bioadhesive property Carboxy methyl cellulose +++ Hydroxyl propyl methyl cellulose +++ Carbopol 934 +++ Tragacanth +++ Sodium alginate +++ Polycarbophil +++ Hydroxyl ethyl cellulose +++ Gelatin ++ Guar gum ++ Gum karaya ++ Pectin + Acacia + Polyvinyl pyrrolidone + NOTE : +++ Excellent ++ Moderate + Poor

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Types of Drug delivery systems 1) Buccal delivery system 2 ) Sub lingual delivery system 3) Vaginal delivery system 4 ) Rectal delivery system 5 ) Nasal delivery system 6 ) Ocular delivery system 7 ) Gastro intestinal delivery system

Factors affecting Mucoadhesion :

Factors affecting Mucoadhesion 1. Polymer related factors i) Molecular weight : ii)Concentration of active polymer iii)Flexibility of polymer chains 2.Environment related factors i )pH of polymer - substrate interface ii) Applied strength iii) Initial contact time iv)Swelling 3.Physiological factors i) Mucin turn over ii)Disease state

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Method for the evaluation of mucoadhesive 2. Measurement of the Residence Time/In Vivo Techniques 1. In -vitro bioadhesion studies 1)GI Transit using Radio-Opaque Tablets 2)Gamma Scintigraphy Technique

ADVANTAGES:

ADVANTAGES Mucoadhesive dosage forms have three distinct advantages when compared to conventional dosage forms 1) These dosage forms are readily localized in the region applied to improve and enhance the bioavailability of drugs . 2) These dosage forms facilitate intimate contact of the formulation with the underlying absorption surface. This allows modification of tissue permeability for absorption of macromolecules ,such as peptides and proteins. Inclusion of penetration enhancers such as Sodium glycocholate, Sodium taurocholate and L- lysophosphotidyl choline and protease inhibitors in the mucoadhesive dosage forms resulted in better absorption of peptides and proteins. 3) Mucoadhesive dosage forms also prolong the residence time of the dosage form at the site of application and absorption to permit once or twice a day dosing.

DISADVANTAGES:

DISADVANTAGES Medications administered orally do not enter the blood stream immediately after passage through the buccal mucosa. Instead they have to be swallowed and then have to pass through a portion of the GIT before being absorbed. So the action is not very rapid in the GIT as compared when the drug is administered through buccal route. Certain drugs when ingested undergo drug destruction, there are several drugs which are potentially in this category. Many drugs affect liver metabolism and also cause destruction via first pass metabolism of other drugs. Oral ingestions results in more exposure of a drug to the GI tract . One of the side effects of many antibiotics is the destruction of normal GI flora resulting in diarrhea and overgrowth with dangerous organisms such as C. difficile. The absorption of mucoadhesive drugs is adversely affected by the presence of food. Tetracyclines, in particular, complicates the administration of this class of antibiotics via the oral route.

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CONCLUSION The mucoadhesive dosage forms offer prolonged contact at the site of administration, low enzymatic activity, and patient compliance. The formulation of mucoadhesive drug delivery system depends on the selection of suitable polymer with excellent mucosal adhesive properties and biocompatibility. Now researchers are looking beyond traditional polymers, in particular next-generation mucoadhesive polymers ( lectins , thiols, etc.); these polymers offer greater attachment and retention of dosage forms. However, these novel mucoadhesive formulations require much more work, to deliver clinically for the treatment of both topical and systemic diseases.

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REFERENCES Shaikh R., Singh T.R.R., Garland M.J., A David Woolfson , and Ryan F. Donnelly, Mucoadhesive drug delivery systems. J Pharm Bioallied Sci. 2011 Jan–Mar; 3(1): 89–100. 2. Edsman K., Hägerström H., Pharmaceutical applications of mucoadhesion for the non-oral routes. J Pharm Pharmacol . 2005 Jan;57(1):3-22. 3. Varum F.J., McConnell E.L., Sousa J.J., Veiga F., Basit A.W., Mucoadhesion and the gastrointestinal tract. Crit Rev Ther Drug Carrier Syst. 2008;25(3):207-58. 4. Jiang L., Gao L., Wang X., Tang L., Ma J.. The application of mucoadhesive polymers in nasal drug delivery. Drug Dev Ind Pharm. 2010 Mar;36(3):323-36.

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