SUPPOSITORIES PPT

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LECTURE NOTES ON SUPPOSITORIES

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By: ainaljabeen (23 month(s) ago)

sir plz send me dz presntation i wil b very thnkful 2 u itz my id sweetaini15@yahoo.com sir at mnday z my prezntation

By: swati.talele (24 month(s) ago)

plz send me this ppt on sgt77@rediffmail.com

By: jitendra261 (39 month(s) ago)

please mail me your presentation on jitendra261@gmail.com

By: ravi16.16 (40 month(s) ago)

Amit sir .... pls mail me on ravi16.16@rediffmail.com

By: dpp_deepak (40 month(s) ago)

dear sir plz send me this ppt to my email id dpp_deepak@yahoo.com (Deepak pawar Asst. professor, Ratnagiri)

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Presentation Transcript

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1 SUPPOSITORIES Amit M . Gupta, Lecturer, Agnihotri College Of Pharmacy, Wardha (M.S)

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2 A SUPPOSITORY IS A MEDICATED SOLID DOSAGE FORM GENERALLY INTENDED FOR USE IN RECTUM, VAGINA AND TO A LESSER EXTENT IN URETHRA. VAGINAL SUPPOSITORIES ARE ALSO KNOWN AS PESSARIES. SUPPOSITORY

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6 DRUGS HAVING LOCAL AND SYSTEMIC EFFECT CAN BE ADMINISTERED. PROSTAGLANDIN –CONTAINING VAGINAL SUPPOSIT--ORIES FOR INTRUPTION OF EARLY PREGNANCY TREATMENT OF CONSTIPATION AND HEMORRHOIDS. USE FOR SYSTEMIC EFFECT WHEN ORAL MEDICATI- -ON WOULD NOT BE RETAINED OR ABSORB PROPERLY SUCH AS IN NAUSEA & VOMITING USES

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7 Absorption

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8 Rectum Absorption Terminal 15-19 cm of large intestine (LI) Rectal Fluids -> no buffering capacity – 1. 2 - 3 mL – pH 6.8 – Mild environment / drug can change pH – LI function absorb H2O and electrolytes Low S area -> poor absorption compare SI – Rectum usually empty of feces

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10 Rectal Blood Circulation Main blood supply superior rectal artery Blood return 3 blood veins – Superior hemorrhoidal vein – Middle hemorrhoidal vein – Inferior hemorrhoidal vein

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13 Vagina ABSORPTION Fibromuscular tub about - 7.5 cm long Vaginal Blood Circulation – Blood supply vaginal artery (branch of iliac) – Blood return avoids the hepatic portal system Typically targeted drug administration Vaginal fluids – Origin in cervix – Protective mucus Complex mixture of proteins and polysaccharides – Low pH 3 <- (3.5 - 4.2) -> 6 – Prepuberal & post-menopause neutral to slightly alkaline

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14 Urethra Absorption Tube – Males 20 cm – females 4 cm Poorly perfused by blood

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24 SUPPOSITORIES BASES THEY ACT AS A VEHICAL FOR MEDICAMENTS

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26 NON-TOXIC HAS NO METASTABLE FORM NON-SENSITIZING WETTING & EMULSIFYING PROPERTY IT CAN BE MANUFACTURED BY MOULDIGNG BY HAND OR BY MACHINE,COMPERATION

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27 IF THE BASE IS FATTY THEN ACID VALUE IS BELOW 0.2 SAPONIFICATION VALUE RANGES FROM 200 – 245 IODINE VALUE IS LESS THAN 7 THE INTERVAL BETWEEN MELTING POINT & SOLIDIFICATION POINT IS SMALL

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49 AUTOMATIC MOLDING MACHINE POURING COOLING REMOVAL PAKAGING

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50 PACKAGING OF MOLDED SUPPOSITORIES IN PACKAGE

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51 APROCHES OF FORMULATING SUPPOSITORIES LOCAL & SYSTEMIC USE APPLICATION FOR VAGINA,RECTAL & URETHRAL QUICK & PROLONG ACTION

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52 SPECIFIC PROBLEMS IN FORMULATING WATER IN SUPPOSITORIES HYGROSOPICITY INCOMPATIBILITY VISCOSITY BRITTELNESS

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53 DENSITY VOLUME CONTRACTION LUBRICANTS DOSES REPLACEMENT FACTOR f=100(E-G) / (G)(X) + 1

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54 WEIGHT & VOLUME CONTROL RANCIDITY & ANTIOXIDANTS

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55 TESTING OF SUPPOSITORIES MELTING RANGE TEST SOFTENING TIME TEST OF RECTAL SUPPOSITORIES BREAKING TEST DISSOLUTION TEST

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56 }{ !! THANK YOU!! }{

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