MANIA

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Presentation On Antimanic drugs By: Amanpreet singh B.Pharmacy 5 th sem 104942539035

Lithium carbonate:

Lithium carbonate Lithium exerts beneficial effects in manic patients Suppress mania and exert prophylactic effects Given in doses which have no overt CNS effects

Actions and mechanism:

Actions and mechanism ON CNS : Acts as mood stabilizing drug Given to paitents in acute mania Gradually suppresses the episodes taking 1-2 weeks Continued treatment prevents cyclic mood changes

Mechanism :

Mechanism Lithium inhibits hydrolysis of inositol-1-phosphate Supply of IP3 and DAG reduced Hyperactive neurons get affected This dampens the signal transduction

Pharmacokinetics :

Pharmacokinetics Absorption rate is slow Distribution : 1 st in cells and then goes to CNS then throughout the body Not metabolized in body and neither protein bound Excretion through kidneys and t 1/2 is 16-30 hours

Adverse effects:

Adverse effects Nausea, vomiting and mild diarrhoea Thirst and polyuria Fine tremors and rarely seizures Long term use, renal diabetes insipidus and goiter It is contraindicated during pregnancy

USES:

USES IN ACUTE MANIA : used as neuroleptic Given by i.m route along with potent BZD IN BIPOLAR DISORDER: Its plasma concentration is maintained b/w 0.5-0.8 mEq/L IN recurrent neuropsychiatric illness

Interactions :

Interactions Diuretics like thiazide e.g Tetracylins, NSAIDs and ACE inhibitors Enhance insulins in body

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