introduction & evaluation of herbal drugs (hepatoprotective)

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INTRODUCTION Heptoprotective drugs are that prevent the liver disease. The liver is the organ located upper right hand side of the abdomen mostly rib cage. Liver disease is a term for a collection of conditions, diseases ,and infections that effect the cells, tissue, structures, functions of the liver. Liver has many jobs including changing food in to energy and cleaning alcohol and poisons from the blood. It also makes bile, a yellowish-green liquid that help digestion.

Evaluation Of Herbal Drugs:

Evaluation Of Herbal Drugs Evaluation of a drug means confirmation of its identity & determination of its quality & purity & detection of its nature of adulteration. Evaluation of herbal drugs include- BIOASSAY - Biological potency of the herbal constituents is due to not one but a mixture of bioactive plant constituents.

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Some of the examples are- Evaluation of adaptogenic activity profile of herbal preparations - Adaptogens help the body to come up with stress & enhance general health performance. Ex- AVM, Composition- Emblica officinalis, Withania somnifera, Asparagus racemosus, Ocimum sanctmum, Tribulus terrestris & Piper longum. AVM shows significant anti stress, immunomodulatory & anabolic activities in different animal models there by proving a promising adaptogen. Evaluation of antioxidant activity of herbal products - A new test method for measuring the anti-oxidant power of herbal product s, based on solid phase spectrophotometry using tetrabenzo-b,f,j,n,l,5,9,13-tetra azacy-clohexadecin-Cu(II) complex immobilized on silica gel proposed . The method represents an alternative to the mostly used scavenging capacity assays . The method was approved in the analysis of the most popular herbal beverages and drugs.

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EVALUATION OF MICROBIAL CONTAMINATION REDUCTION ON PLANTS THROUGH TECHNOLOGICAL PROCESS OF DECOCTION AND SPRAYED DRIED :- The technological process of raw material has many stages , generally , adverse to microbial growth but it’s complete elimination depends on the initial and work condition utilized . The aim of this work was to verify by microbial contamination such as extractive solution and spray dried extract with the purpose of evaluating the decrease of contamination after the decoction and the sprayed dried.

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The lipid inhibitory activity :- The reaction mixture contain mice liver in 0.15 KCl , KCl (0.1ml,150 μ m), Triss buffer (0.4ml,pH 7.5) and various concentration of test extract . In vitro lipid per oxidation was initiated by addition of FeSO 4 .7H 2 O (0.1ml,10 μ m) . The reaction mixture was incubated at 37degree Celsius for 1 hr. After the incubation period ,reaction was terminated by addition of thio-barbituric acid (2ml,0.8%) and by heating the content for 15min. For development of colored complex . The tubes were then centrifuge at 4000rpm for 10min. and cool . The % inhibition of lipid per oxidation was determine comparing the results of test compound with those of control not treated with extract by monitoring the color intensity at 532nm .

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THERMOGRAPHIC EVALUATION :- Thermographic evaluation is used to evaluate the effects of herbal formulation based on “Sho” scientifically. It suggested that thermography is useful for an objective evaluation of “Sho” , and for identification of the action site of the herbal formulation . BIOCHEMICAL EVALUATION:- This technique is used when herbal drugs contain mixture of a no. of ingredient e.g.:- MUTHU MARUNTHU is an herbal formulation comprising of 8various plant ingredient and has been claimed to posses anticancer effect . It was observe the growth rates in rat was normal and there was no change in blood parameter and also in the activities of enzyme such as lactate dehydrogenase, gluconate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPTE), alkaline and acid phosphatase after MUTHU MARUNTHU administration. The tumor weight was found to be reduced in methylcholanthrene induced fibrosarcoma rats after MUTHU MARUNTHU treatment.

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ORAGANOLEPTIC EVALUATION: - Oraganoleptic evaluation of food products plays an important role in judging the censoring acceptability or rejection of food item in the market. The overall acceptability of the product was significantly higher in 70% sugar syrup but these scores decreased as the storage period advanced .

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HEPATOPROTECTIVE HERBAL DRUGS Taraxacum officinale It has been used as a remedy for jaundice and other disorders of liver and gall bladder. The roots of the plant have the most activity regarding the liver and gall bladder. Bitter constituents like taraxecerin and taraxcin are active constituents of this plant. Cichorium intybus :- It is a popular ayurvedic remedy for treatment of liver disease. In mice, liver protection was observed at various dosage of Cichorium intybus but optimum protection was seen with a dose of 75mg/kg. Cichorin (C32H34O19) has been reported to be the active constituent of the herb.

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Solenum nigrum :- Aromatic water extracted from the drug is widely prescribed by herbal vendors for liver disorders. Glychyrrhiza glabra:- It is commonly known as licorice. It contains tri terpene saponin, known as glycyrrhizin, which has potential hepto protective activity. The effects include, reducing the degeneration and narcosis and recovering the glycogen and R.N.A of liver cells.

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Wilkstroemia indica:- It is a Chinese herb and has been evaluated in patients suffering from hepatitis B. Dicoumarin, Daphnoretin is the active constituent herb. Curcuma longa:- Turmeric has been found to be protect animal liver from a variety of heptotoxic substances. Curcumin is active constituent of the plant. Tephrosia purpurea :- Alkali prepartion of the drug commonly used in the treatment of spleen and liver diseases. The roots,leaf,seeds contain tephrosin, deguelin and quercitein. The heptoprotective constituent of the drug is sill to be proved.

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