logging in or signing up mercury poisoning aishu12 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Copy Does not support media & animations WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 873 Category: Entertainment License: All Rights Reserved Like it (1) Dislike it (0) Added: March 09, 2012 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript PowerPoint Presentation: ` MERCURY POISONINGFORMS OF MERCURY: FORMS OF MERCURY There are 3 different forms of mercury - elemental - inorganic - organic Each has a different toxicological profileSOURCES OF MERCURY: SOURCES OF MERCURY Elemental mercury: Sphygmomanometers, thermometers, barometers Liquid at room temp – volatilises easily Sphygmomanometer s , thermometers barometerSOURCES OF MERCURY: SOURCES OF MERCURY Inorganic mercury: Traditional remedies ( ayurvedic , chinese ) Used in gold extraction, caustic soda manufacturing RodenticidesSOURCES OF MERCURY: SOURCES OF MERCURY Organic mercury: Fungicides, seed dressings Methyl mercury in fishACCUMULATION OF MERCURY: ACCUMULATION OF MERCURYABSORPTION OF MERCURY: ABSORPTION OF MERCURY Inhalation : 60-80% Dermal : 3-15% GI Tract : Metallic <0.2% Inorganic 15% Organic 90 + %Organic mercury poisoning: Organic mercury poisoning Rare but severe Effects: CNS Toxicity: poor concentration, fatigue, ataxia, tremor, constricted visual fields, coma & convulsions BM suppression Renal toxicity - dealkylation to inorganic form Poorer response to treatmentInorganic mercury poisoning: Inorganic mercury poisoning Gastrointestinal phase : Hg 2+ is a potent GI irritant gingivitis, stomatitis oesophageal, gastric, small and large bowel erosions haematemesis, diarrhoea, CVS collapse Systemic toxicity : Hg 2+ inhibits sulphydryl enzymes hypotension, lactic acidosis Nephrotoxicity : Hg 2+ deposits in the tubules acute renal failure potentially leads to CRF in survivors Biopsy of kidney showing mercury in itElemental Mercury poisoning: Elemental Mercury poisoning ACUTE: Irritant respiratory effects: cough, dyspnoea pulmonary oedema Metal fume fever: pyrexia, cough, malaise, flu-like symptoms CNS features: confusion, emotional lability, psychoses convulsions, CNS depression & coma Renal effects: rarely ARFElemental Mercury poisoning: Elemental Mercury poisoning CHRONIC: ‘ Erethism ’ TREMOR, dysarthria peripheral neuropathy, sweating personality change Stomatitis, gingivitis Chronic renal impairment Acrodynia - related to elemental mercury exposure in children Acrodynia gingivitis stomachitisPowerPoint Presentation: local complications Systemic toxicity i.v / i.m injection causes complication as depicted:Pulmonary absorption on inhalation: Pulmonary absorption on inhalation Healthy lungs Lungs with mercury(inhaled)Diagnosis: Diagnosis Blood mercury: only really useful acutely normal <10µg/l symptoms with blood mercury >150-200µg/l Urine mercury: probably the most reliable indicator normal <10µg/l symptoms with urine mercury >100-150µg/l U&E Radiology: for elemental ingestion/aspiration/injectionTHERAPY: THERAPY Dimercaprol widely used for inorganic mercury; effective for protection of kidney (Hg++) ineffective from protection of brain (CH3Hg+) cannot be given orally, side effects Pencillamine given orally effective for Hg, less so for CH3Hg+ some side effects Dimercaptosuccinic acid (DMSA) given orally probably effective for CH3Hg+, Hg, Hg++ low toxicity Polythiol resion CH3Hg+ only pencillamine DMSA dimercaprol You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
mercury poisoning aishu12 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Copy Does not support media & animations WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 873 Category: Entertainment License: All Rights Reserved Like it (1) Dislike it (0) Added: March 09, 2012 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript PowerPoint Presentation: ` MERCURY POISONINGFORMS OF MERCURY: FORMS OF MERCURY There are 3 different forms of mercury - elemental - inorganic - organic Each has a different toxicological profileSOURCES OF MERCURY: SOURCES OF MERCURY Elemental mercury: Sphygmomanometers, thermometers, barometers Liquid at room temp – volatilises easily Sphygmomanometer s , thermometers barometerSOURCES OF MERCURY: SOURCES OF MERCURY Inorganic mercury: Traditional remedies ( ayurvedic , chinese ) Used in gold extraction, caustic soda manufacturing RodenticidesSOURCES OF MERCURY: SOURCES OF MERCURY Organic mercury: Fungicides, seed dressings Methyl mercury in fishACCUMULATION OF MERCURY: ACCUMULATION OF MERCURYABSORPTION OF MERCURY: ABSORPTION OF MERCURY Inhalation : 60-80% Dermal : 3-15% GI Tract : Metallic <0.2% Inorganic 15% Organic 90 + %Organic mercury poisoning: Organic mercury poisoning Rare but severe Effects: CNS Toxicity: poor concentration, fatigue, ataxia, tremor, constricted visual fields, coma & convulsions BM suppression Renal toxicity - dealkylation to inorganic form Poorer response to treatmentInorganic mercury poisoning: Inorganic mercury poisoning Gastrointestinal phase : Hg 2+ is a potent GI irritant gingivitis, stomatitis oesophageal, gastric, small and large bowel erosions haematemesis, diarrhoea, CVS collapse Systemic toxicity : Hg 2+ inhibits sulphydryl enzymes hypotension, lactic acidosis Nephrotoxicity : Hg 2+ deposits in the tubules acute renal failure potentially leads to CRF in survivors Biopsy of kidney showing mercury in itElemental Mercury poisoning: Elemental Mercury poisoning ACUTE: Irritant respiratory effects: cough, dyspnoea pulmonary oedema Metal fume fever: pyrexia, cough, malaise, flu-like symptoms CNS features: confusion, emotional lability, psychoses convulsions, CNS depression & coma Renal effects: rarely ARFElemental Mercury poisoning: Elemental Mercury poisoning CHRONIC: ‘ Erethism ’ TREMOR, dysarthria peripheral neuropathy, sweating personality change Stomatitis, gingivitis Chronic renal impairment Acrodynia - related to elemental mercury exposure in children Acrodynia gingivitis stomachitisPowerPoint Presentation: local complications Systemic toxicity i.v / i.m injection causes complication as depicted:Pulmonary absorption on inhalation: Pulmonary absorption on inhalation Healthy lungs Lungs with mercury(inhaled)Diagnosis: Diagnosis Blood mercury: only really useful acutely normal <10µg/l symptoms with blood mercury >150-200µg/l Urine mercury: probably the most reliable indicator normal <10µg/l symptoms with urine mercury >100-150µg/l U&E Radiology: for elemental ingestion/aspiration/injectionTHERAPY: THERAPY Dimercaprol widely used for inorganic mercury; effective for protection of kidney (Hg++) ineffective from protection of brain (CH3Hg+) cannot be given orally, side effects Pencillamine given orally effective for Hg, less so for CH3Hg+ some side effects Dimercaptosuccinic acid (DMSA) given orally probably effective for CH3Hg+, Hg, Hg++ low toxicity Polythiol resion CH3Hg+ only pencillamine DMSA dimercaprol