NEEDLE-FREE INJECTION TECHNOLOGY

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To educate the people about NEEDLE-FREE INJECTION TECHNOLOGY and its DEVICE .

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Presentation Transcript

Needle free injection technology:

Needle free injection technology Seminar by K.ADITYA (07FD1R0020) Under the guidance of Ms. SWATHI ( M.Pharm ) MAHESWARA COLLEGE OFPHARMACY

Contents:

Contents Introduction Structure Mechanism Technology Application Conclusion Reference s

Introduction:

I ntroduction To overcome the problems related to needle based injections, there is one technology that has received constant attention during the past few years that has all of the sought after benefits--- Needle Free injection technology (NFIT) was discovered in 19 th century in France. Needle free technology offers the vary obvious benefits of reducing patient concern about the use of needle. The main use of this needle free technology is to reduce patient phobia towards needle injectio n . This is mainly useful for the patients who are suffering form chronic diseases who requires injectable products 2-3 a day. For Examples : Diabetes patients.

Description:

Description The pharmaceutical subject include Glass tube Pistons Nozzle made of standard material. Can be easily filled in on conventional filling lines. Recently Guide Pharma introduces a new model of needle free injections. Different types of needle free injection were designed based on the type of drug to be injected which are explained below.

Mechanism :

Mechanism Needle free injection technology works by forcing liquid medications at high speed through a tiny orifice that is held against the skin . This creates an ultra stream of high pressure fluid that penetrates the skin without the use of needle. The design of this device has a major influence on the accuracy of subcutaneous delivery and the stresses improved on the product to be delivered. The design must ensure that a sufficient high pressure is generated to puncture the skin, while the subsequent pressure is reduced to ensure that the molecule is deposited at a level that doe’s not reach the muscle tissue.

Slide 8:

High pressure delivery could potentially damage fragile molecules , such as monoclonal antibodies. Successful delivery of such molecules, therefore requires a device with carefully controlled power nuances.

Technologies:

Technologies Mhi-500 Mhi-500 is a needle free insulin delivery system which offers a great benefit in diabetes care. Mhi-500 injects insulin by using a fine, high pressure jet of insulin. This jet then penetrates the tissue, depositing the insulin in the subcutaneous layer. This jet is created by forcing the insulin through precisely designed nozzle that is held in contact with the tissue during the inject

Recoject:

Recoject Recoject is India's first needle free insulin device and is poised revolutionise the insulin therapy. This is a needle free insulin device is mainly lanched for infected Recoinsulin (recombinant human insulin).

Bioject’s needle free technology:

Bioject’s needle free technology This injection technology works by forcing liquid medication at high speed through a tiny orifice that is held against the skin. The diameter of the orifice is smaller than the diameter of human hair. This creates an ultra fine stream of high pressure fluid that penetrates the skin without single needle. This is unique because it delivers injections to a number of injection depth.

Vita jet 3:

Vita jet 3 This vita jet 3 is easy to use ,economical needle free injection system for delivering insulin. It does not requires re-assembly. With disposable nozzles that are replaced once in a week, the vita jet3 offers the quality of re un usable medical products, with the convenience and safety of sterile products. The exclusive easy to read crystal check disposable transparent nozzle visually loading and full discharge of insulin.

Cool. click:

Cool. click Cool. Click needle free injection system was developed by bioject for delivering saizen recombinant human growth hormone. This system includes customised dosage features to accurately deliver variable doses of saizen and was designed with bright colors to make the injector attractive and non-threatening to children.

Iject:

I ject It has gas powering injectors develop by bioject. It is prefilled single used disposable device configured to administered 0.5-1ml subcutaneous or intramuscular injections. This device is primed by rotating the trigger sleeve 180 and injection is administered by advancing the trigger sleeve while the nozzle is held against the injection site. It is ready to use and it is about the size of fountain pen. The energy to drive the actuator forward to delivery the0.5-1 ml is provided by the compressed nitrogen. The delivery process is completed with less than 60 milliseconds with less bruising.

Biovalve’s mini-jet technology:

Biovalve’s mini-jet technology The mini-jet can deliver wide range of drugs, ranging from small molecule to large proteins, fragile antibiotics and vaccines. Its features are accuracy reliability, a variety of pre-filled option comfortable administration, full disposability and patient friendly easy to design. It is the only needle free technology which can deliver drugs to intra dermal, subcutaneous or intramuscular layer depending on the clinical need.

Advantages :

Advantages It is trouble free, simple & self administration. Low sensation and safety. Solid dosage forms can be administered. Elimination of needle phobia. Minimal skin response and no bleeding or brushing. Easy and safe disposable. Easy to transport and store without refrigeration. Excellent dose response is observed with increasing drug doses. Rapid delivery of drug to systemic circulation. Bio-equivalence has been demolished enabling the development of generic drug proteins.

Conclusion :

Conclusion Needle free technology offers the very obvious benefits of reducing patient concern about conventional needles and no needle disposable issues. Not only it can benefit pharmaceutical industry in increasing product sales, it has the added potential to increase compliance with dosage regimens and improved outcomes In the developing world, there are major challenges of disease transmission through re use of needles. Organizations such as WHO and CDC(center for disease control) and groups like gate foundation have supported the development of needle free alternatives for drug delivery.

Slide 21:

The biotech revolution is bringing the range of protein –based therapeutics into the market place at a rapid pace more than 300 products in active development. These protein-based therapeutics especially monoclonal antibodies (MAbs), which are anticipated to represent 30 per cent of pharmaceutical sales by 2009 and which are otherwise challenging to deliver non-invasively, will continue to be formulated as injectables. It is likely that dramatic change may occur only when a large pharmaceutical or biotechnology company adopts needle-free technology and demonstrates its versatility, acceptance and value in major therapeutic area.

References:

References Wikipedia www.expresshealthcaregmt.com www.pharmatechnology.com www.glidepharma.com www.cdc.gov

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