logging in or signing up PULSATILE abikesh086 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 2295 Category: Education License: All Rights Reserved Like it (11) Dislike it (0) Added: September 07, 2009 This Presentation is Public Favorites: 3 Presentation Description No description available. Comments Posting comment... By: sdumair (7 month(s) ago) hiii buddy...nice and structured work....i want to take ur ppt as reference for ma journal...so i request u to forward a copy of this to my mail id.... hoping kind and positive response... thanks ( sd_umair@yahoo.com ) Saving..... Post Reply Close By: balau289 (2 month(s) ago) Iam Bala Gangadhar, and iam to give a presentation in the college about pulsincap, and hope this presentation helps me . So kindly send me a copy of this topic Saving..... Edit Comment Close By: kmtaks (8 month(s) ago) Hi, this is a very genuine presentation, i have decided to study and make PDDS as my desertation protocol, this presentation will serve me as a accurate reference in my work. Plz do send me copy of this presentation on my email kmtaks@gmail.com Regards, Akshay. Saving..... Post Reply Close Saving..... Edit Comment Close By: yasmina194 (11 month(s) ago) very very nice Saving..... Post Reply Close Saving..... Edit Comment Close By: rajwani.445 (14 month(s) ago) Hi I am doing my thesis on this topic i.e. Pulsatile DDS. So please send me the soft copy of this which will help me in my thesis work. Thanking you Yogesh Shirode Please send me a copy on yogeshshirode26apr@gmail.com Saving..... Post Reply Close By: balau289 (2 month(s) ago) hi, iam to give a seminar on this topic, so please send me the soft copy of this, so that it could be helpful in my presentation. bala Gangadhar. Send me a copy to balau289@hotmail.com. Thanks in advance Saving..... Edit Comment Close By: mayur_here4u (14 month(s) ago) hey there nice ppt plz send me a copy on mayur_here4u@yahoo.com Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Slide 1: WELCOME PULSATILE DRUG DELIVERY” : 2 PULSATILE DRUG DELIVERY” PRESENTED BY ABIKESH PRASAD KUMAR MAHAPATRA M.PHARM(PHARM TECHNOLOGY) 2 nd SEMESTAR Regd No.:-0808254026 Slide 3: Introduction What is pulsatile drug delivery system Condition demanding pulsatile drug release Disease requiring pulsatile drug delivery Methodologies for pulsatile drug delivery Marketed technologies for pulsatile drug delivery (Marketed products) Recent advances in pulsatile drug delivery Summary Conclusion CONTENTS Slide 4: With the advancement of technologies in the pharmaceutical field, drug delivery system have drawn an increasing interest over the last few decades. Now a days more emphasis of pharmaceutical galenic research is turned towards the development of more efficacious drug delivery system with already existing molecule rather than finding for a new drug discovery because of the interest posed in drug discovery and development process. 1 st Approach :- Drug should absorbed predictabely from site of injection or gut 2 nd Approach :- Controll release (0 order) Living organism are not 0 order in their response to drug. Now a days concepts of chronopharmaceutics has emerged where is research is devoted to the design and evaluation of drug delivery system that releases a therapeutic agent at a rhythm that ideally match the biological requirement of a given disease therapy. Circadian rhythm regulates many body functions in humans viz metabolism, physiology, behaviour, sleep pattern, hormone production etc.. Disease where a constant drug levels are not preferred but needs a pulse of therapeutic concentration in a periodic manner acts as a push for the development of pulsatile drug delivery system. Now, a days release of some drugs preferred in pulses. INTRODUCTION WHAT IS PULSATILE DRUG DELIVERY SYSTEM : WHAT IS PULSATILE DRUG DELIVERY SYSTEM Pulsatile drug delivery system are gaining a lot of interest and importance as they deliver the drug at the right site, at right time and right amount as per the pathophysiology need of the disease thus providing a spatial and temporal delivery resulting in improved patient therapeutic efficacy and compliance. Slide 6: What is pulsatile drug delivery ? Certain conditions demand release of drug after a initial lag time ; followed by a late drug pulse with the enclosed active quantity being released at once. Such a release pattern is known as pulsatile release. Slide 7: Conditions demanding pulsatile drug release : Diseases displaying time dependence ( bronchial asthma, myocardial infarction, rheumatic disease and hypertension. Drugs producing biological tolerance. Drugs undergoing degradation in gastric acidic medium (e.g., peptide drugs). Colon targeting requires drug release being prevented in upper two-third portion of the GIT. Drugs undergoing extensive first-pass metabolism (β-blockers). . DISEASE REQUIRING PULSATILE DRUG DELIVERY SYSTEM : DISEASE REQUIRING PULSATILE DRUG DELIVERY SYSTEM Thorough understanding of the disease physiology is required before designing the pulsatile drug delivery system. Disease where rhythmic circadian organization of the body plays an important role, pharmacokinetic and pharmacodynamic of the drugs is not constant with in 24 hours. MARKETED TECHNOLOGIES OF PULSATILE DRUG DELIVERY : MARKETED TECHNOLOGIES OF PULSATILE DRUG DELIVERY A lot of work is being done to achieve pulsatile release so that the drug release can be delivered according to circadian rhythm of our body. Methodologies for pulsatile drug delivery : Methodologies for pulsatile drug delivery Cont…. : Cont…. Cont….. : Cont….. Slide 13: Single-unit systems a. Capsular system ( Pulsincap® system ) Currently reported pulsatile systems Shewta Arora et al., IJPS, May-June 2006 Slide 14: b. System based on Osmosis ( Port® System) : This system proposed to deliver methylphenidate for the treatment of attention deficit hyperactivity disorder (ADHD) in school-age children. Slide 15: c. Pulsatile system with Erodible or Soluble Barrier Coatings Time Clock® system: (for Water-soluble drugs ) -Lipidic barriers (carnuba wax ), Surfactants (polyoxyethylene sorbitan monooleate). - Coat erodes in aqueous environment and then core is available for dispersion. Chronotropic® system : -Core coated by hydrophilic swellable HPMC, responsible for a lag phase. Slide 16: d. Pulsatile system with Rupturable Coatings : - Systems depends on disintegration of coating for release of drug by superdisintegrants (like Cross carmellose, Sodium starch glycollate). - Pressure for rupture of coating achieved by effervescent excipients (citric acid and sodium bicarbonate), swelling agents, or osmotic pressure. - This system can be used for delivery of both solid and liquid drug formulations. . Slide 17: Multiparticulate (pellets) systems : a. Pulsatile System Based on Rupturable Coating : -Time-Controlled Explosion System : Drug coated on non-pareil sugar seeds, followed by swellable layer which include superdisintegrants and an insoluble top layer. b. Pulsatile Delivery by Change in Membrane Permeability : -Permeability of acrylic polymers with quaternary ammonium groups (e.g.-Eudragit RS 30D) influenced presence of different counter-ions (negative hydrochloride ions) in the medium. Stimuli Induced : Stimuli Induced In these systems there is release of the drug after stimulation by any biological factor like temperature,or any other chemical stimuli These systems are further classified in to temperature induced systems and chemical stimuli induced system, on the basis of stimulus. Temperature induced systems Thermo-responsive hydrogel systems have been developed for pulsatile release. In these systems the polymer undergoes swelling or deswelling phase in response to the temperature which modulate drug release in swollen state. Chemical stimuli induced Pulsatile systems : Chemical stimuli induced Pulsatile systems Glucose-responsive insulin release devices In case of diabetes mellitus there is rhythmic increase in the levels of glucose in the body requiring injection of the insulin at proper time. Several systems have been developed which are able to respond to changes in glucose concentration. One such system includes pH sensitive hydrogel containing glucose oxidase immobilized in the hydrogel. When glucose concentration in the blood increases glucose oxidase converts glucose into gluconic acid which changes the pH of the system. This pH change induces swelling of the polymer which results in insulin release. decreased and system turns to the deswelling mode thereby decreasing the insulin release. Examples of the pH sensitive polymers includes N,N- dimethylaminoethyl methacrylate, chitosan, polyol etc. Inflammation-induced pulsatile release : Inflammation-induced pulsatile release On receiving any physical or chemical stress, such as injury, fracture etc., inflammation take place at the injured sites. During inflammation, hydroxyl radicals are produced from these inflammation-responsive cells. pH sensitive drug delivery system Such type of pulsatile drug delivery system containstwo components one is of immediate release type and other one is pulsed release which releases the drug in response to change in pH. In case of pH dependent system advantage has been taken of the fact that there exists different pH environment at different parts of the gastrointestinal tract. By selecting the pH dependent polymers drug release at specific location can be obtained. Examples of pH dependent polymers includes cellulose acetate phthalate, polyacrylates, sodium carboxymethylcellulose. . Externally regulated systems : . Externally regulated systems For releasing the drug in a pulsatile manner, another way can be the externally regulated systems in which drug release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. Magnetically regulated system contain magnetic beads in the implant. On application of the magnetic field, drug release occurs because of magnetic beads. Saslawski et al. developed different formulation for in vitro magnetically triggered delivery of insulin based on alginate spheres23. In case of ultrasonically modulated systems, ultrasonic waves causes the erosion of the polymeric matrix thereby modulating drug release RECENT ADVANCES IN PULSATILE DRUG DELIVERY : RECENT ADVANCES IN PULSATILE DRUG DELIVERY pulsatile drug delivery systems are gaining importance in various disease conditions specially in diabetes where dose is required at different time interval. Among these systems, multiparticulate systems (e.g. Pellets) offer various advantages over single unit which include no risk of dose dumping, different release pattern as well as short and reproducible gastric residence time. Multiparticulate systems consists pellets of different release profile which can be of any type like time dependent,pH dependent,microflora activated system etc. Site and time specific oral drug delivery have recently been of great interest in pharmaceutical field to achieve improved therapeutic efficacy. Several approaches like Gastro retentive drug delivery system, Floating drug delivery system etc. Low density porous multiparticulate systems are used by researcher for formulation of, floating drug delivery system. Sharama and Powar developed multiparticulate floating pulsatile drug delivery system using porous calcium silicate and sodium alginate for time and site specific drug release of meloxicam. New technologies are discussed in marketed products. Under Phase I/II Clinical trials, Pulsysa versions of clarithromycin, metronidazole, amoxycillin/clavulanate combination by Advancis Pharmaceutical Corp., Maryland, USA. SUMMARY : SUMMARY Especially disease with chronological pharmacology pulsatile drug delivery system was beneficial. By using any of the approaches described above the pulsatile drug delivery system can be formulated successively. The pulsatile drug delivery system is the best approach for the diseases releated to chronopharmacokinetics. : There is a constant need for new delivery systems that can provide increased therapeutic benefits to the patient. Sustained release formulations are not efficient in treating the disease especially disease with chronological pharmacology for which pulsatile drug delivery system was beneficial Pulsatile drug delivery IS one such system that by delivering drug at the right time, right place, and right amount , hold good premises of benefit to the patients suffering from chronic problems like arthritis,asthma,hypertension etc. Various methodologies are employed for developing pulsatile drug delivery and there are various technologies present in the market based on various methodologies. Pulsatile release systems should be promising in future. CONCLUSION REFERENCES : REFERENCES CONTROLLED DRUG DELIVERY SYSTEM BY N. K. JAIN CONTROLLED DRUG DELIVERY CONCEPT AND ADVANCE BY S.P VYAS WWW.GOOGLE.COM WWW.ASK.COM WWW.AAPSPHARMASCITECH.COM THANK YOU : THANK YOU THANK YOU You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.
PULSATILE abikesh086 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: (To copy code, click on the text box) Embed: URL: Thumbnail: WordPress Embed Customize Embed The presentation is successfully added In Your Favorites. Views: 2295 Category: Education License: All Rights Reserved Like it (11) Dislike it (0) Added: September 07, 2009 This Presentation is Public Favorites: 3 Presentation Description No description available. Comments Posting comment... By: sdumair (7 month(s) ago) hiii buddy...nice and structured work....i want to take ur ppt as reference for ma journal...so i request u to forward a copy of this to my mail id.... hoping kind and positive response... thanks ( sd_umair@yahoo.com ) Saving..... Post Reply Close By: balau289 (2 month(s) ago) Iam Bala Gangadhar, and iam to give a presentation in the college about pulsincap, and hope this presentation helps me . So kindly send me a copy of this topic Saving..... Edit Comment Close By: kmtaks (8 month(s) ago) Hi, this is a very genuine presentation, i have decided to study and make PDDS as my desertation protocol, this presentation will serve me as a accurate reference in my work. Plz do send me copy of this presentation on my email kmtaks@gmail.com Regards, Akshay. Saving..... Post Reply Close Saving..... Edit Comment Close By: yasmina194 (11 month(s) ago) very very nice Saving..... Post Reply Close Saving..... Edit Comment Close By: rajwani.445 (14 month(s) ago) Hi I am doing my thesis on this topic i.e. Pulsatile DDS. So please send me the soft copy of this which will help me in my thesis work. Thanking you Yogesh Shirode Please send me a copy on yogeshshirode26apr@gmail.com Saving..... Post Reply Close By: balau289 (2 month(s) ago) hi, iam to give a seminar on this topic, so please send me the soft copy of this, so that it could be helpful in my presentation. bala Gangadhar. Send me a copy to balau289@hotmail.com. Thanks in advance Saving..... Edit Comment Close By: mayur_here4u (14 month(s) ago) hey there nice ppt plz send me a copy on mayur_here4u@yahoo.com Saving..... Post Reply Close Saving..... Edit Comment Close loading.... See all Premium member Presentation Transcript Slide 1: WELCOME PULSATILE DRUG DELIVERY” : 2 PULSATILE DRUG DELIVERY” PRESENTED BY ABIKESH PRASAD KUMAR MAHAPATRA M.PHARM(PHARM TECHNOLOGY) 2 nd SEMESTAR Regd No.:-0808254026 Slide 3: Introduction What is pulsatile drug delivery system Condition demanding pulsatile drug release Disease requiring pulsatile drug delivery Methodologies for pulsatile drug delivery Marketed technologies for pulsatile drug delivery (Marketed products) Recent advances in pulsatile drug delivery Summary Conclusion CONTENTS Slide 4: With the advancement of technologies in the pharmaceutical field, drug delivery system have drawn an increasing interest over the last few decades. Now a days more emphasis of pharmaceutical galenic research is turned towards the development of more efficacious drug delivery system with already existing molecule rather than finding for a new drug discovery because of the interest posed in drug discovery and development process. 1 st Approach :- Drug should absorbed predictabely from site of injection or gut 2 nd Approach :- Controll release (0 order) Living organism are not 0 order in their response to drug. Now a days concepts of chronopharmaceutics has emerged where is research is devoted to the design and evaluation of drug delivery system that releases a therapeutic agent at a rhythm that ideally match the biological requirement of a given disease therapy. Circadian rhythm regulates many body functions in humans viz metabolism, physiology, behaviour, sleep pattern, hormone production etc.. Disease where a constant drug levels are not preferred but needs a pulse of therapeutic concentration in a periodic manner acts as a push for the development of pulsatile drug delivery system. Now, a days release of some drugs preferred in pulses. INTRODUCTION WHAT IS PULSATILE DRUG DELIVERY SYSTEM : WHAT IS PULSATILE DRUG DELIVERY SYSTEM Pulsatile drug delivery system are gaining a lot of interest and importance as they deliver the drug at the right site, at right time and right amount as per the pathophysiology need of the disease thus providing a spatial and temporal delivery resulting in improved patient therapeutic efficacy and compliance. Slide 6: What is pulsatile drug delivery ? Certain conditions demand release of drug after a initial lag time ; followed by a late drug pulse with the enclosed active quantity being released at once. Such a release pattern is known as pulsatile release. Slide 7: Conditions demanding pulsatile drug release : Diseases displaying time dependence ( bronchial asthma, myocardial infarction, rheumatic disease and hypertension. Drugs producing biological tolerance. Drugs undergoing degradation in gastric acidic medium (e.g., peptide drugs). Colon targeting requires drug release being prevented in upper two-third portion of the GIT. Drugs undergoing extensive first-pass metabolism (β-blockers). . DISEASE REQUIRING PULSATILE DRUG DELIVERY SYSTEM : DISEASE REQUIRING PULSATILE DRUG DELIVERY SYSTEM Thorough understanding of the disease physiology is required before designing the pulsatile drug delivery system. Disease where rhythmic circadian organization of the body plays an important role, pharmacokinetic and pharmacodynamic of the drugs is not constant with in 24 hours. MARKETED TECHNOLOGIES OF PULSATILE DRUG DELIVERY : MARKETED TECHNOLOGIES OF PULSATILE DRUG DELIVERY A lot of work is being done to achieve pulsatile release so that the drug release can be delivered according to circadian rhythm of our body. Methodologies for pulsatile drug delivery : Methodologies for pulsatile drug delivery Cont…. : Cont…. Cont….. : Cont….. Slide 13: Single-unit systems a. Capsular system ( Pulsincap® system ) Currently reported pulsatile systems Shewta Arora et al., IJPS, May-June 2006 Slide 14: b. System based on Osmosis ( Port® System) : This system proposed to deliver methylphenidate for the treatment of attention deficit hyperactivity disorder (ADHD) in school-age children. Slide 15: c. Pulsatile system with Erodible or Soluble Barrier Coatings Time Clock® system: (for Water-soluble drugs ) -Lipidic barriers (carnuba wax ), Surfactants (polyoxyethylene sorbitan monooleate). - Coat erodes in aqueous environment and then core is available for dispersion. Chronotropic® system : -Core coated by hydrophilic swellable HPMC, responsible for a lag phase. Slide 16: d. Pulsatile system with Rupturable Coatings : - Systems depends on disintegration of coating for release of drug by superdisintegrants (like Cross carmellose, Sodium starch glycollate). - Pressure for rupture of coating achieved by effervescent excipients (citric acid and sodium bicarbonate), swelling agents, or osmotic pressure. - This system can be used for delivery of both solid and liquid drug formulations. . Slide 17: Multiparticulate (pellets) systems : a. Pulsatile System Based on Rupturable Coating : -Time-Controlled Explosion System : Drug coated on non-pareil sugar seeds, followed by swellable layer which include superdisintegrants and an insoluble top layer. b. Pulsatile Delivery by Change in Membrane Permeability : -Permeability of acrylic polymers with quaternary ammonium groups (e.g.-Eudragit RS 30D) influenced presence of different counter-ions (negative hydrochloride ions) in the medium. Stimuli Induced : Stimuli Induced In these systems there is release of the drug after stimulation by any biological factor like temperature,or any other chemical stimuli These systems are further classified in to temperature induced systems and chemical stimuli induced system, on the basis of stimulus. Temperature induced systems Thermo-responsive hydrogel systems have been developed for pulsatile release. In these systems the polymer undergoes swelling or deswelling phase in response to the temperature which modulate drug release in swollen state. Chemical stimuli induced Pulsatile systems : Chemical stimuli induced Pulsatile systems Glucose-responsive insulin release devices In case of diabetes mellitus there is rhythmic increase in the levels of glucose in the body requiring injection of the insulin at proper time. Several systems have been developed which are able to respond to changes in glucose concentration. One such system includes pH sensitive hydrogel containing glucose oxidase immobilized in the hydrogel. When glucose concentration in the blood increases glucose oxidase converts glucose into gluconic acid which changes the pH of the system. This pH change induces swelling of the polymer which results in insulin release. decreased and system turns to the deswelling mode thereby decreasing the insulin release. Examples of the pH sensitive polymers includes N,N- dimethylaminoethyl methacrylate, chitosan, polyol etc. Inflammation-induced pulsatile release : Inflammation-induced pulsatile release On receiving any physical or chemical stress, such as injury, fracture etc., inflammation take place at the injured sites. During inflammation, hydroxyl radicals are produced from these inflammation-responsive cells. pH sensitive drug delivery system Such type of pulsatile drug delivery system containstwo components one is of immediate release type and other one is pulsed release which releases the drug in response to change in pH. In case of pH dependent system advantage has been taken of the fact that there exists different pH environment at different parts of the gastrointestinal tract. By selecting the pH dependent polymers drug release at specific location can be obtained. Examples of pH dependent polymers includes cellulose acetate phthalate, polyacrylates, sodium carboxymethylcellulose. . Externally regulated systems : . Externally regulated systems For releasing the drug in a pulsatile manner, another way can be the externally regulated systems in which drug release is programmed by external stimuli like magnetism, ultrasound, electrical effect and irradiation. Magnetically regulated system contain magnetic beads in the implant. On application of the magnetic field, drug release occurs because of magnetic beads. Saslawski et al. developed different formulation for in vitro magnetically triggered delivery of insulin based on alginate spheres23. In case of ultrasonically modulated systems, ultrasonic waves causes the erosion of the polymeric matrix thereby modulating drug release RECENT ADVANCES IN PULSATILE DRUG DELIVERY : RECENT ADVANCES IN PULSATILE DRUG DELIVERY pulsatile drug delivery systems are gaining importance in various disease conditions specially in diabetes where dose is required at different time interval. Among these systems, multiparticulate systems (e.g. Pellets) offer various advantages over single unit which include no risk of dose dumping, different release pattern as well as short and reproducible gastric residence time. Multiparticulate systems consists pellets of different release profile which can be of any type like time dependent,pH dependent,microflora activated system etc. Site and time specific oral drug delivery have recently been of great interest in pharmaceutical field to achieve improved therapeutic efficacy. Several approaches like Gastro retentive drug delivery system, Floating drug delivery system etc. Low density porous multiparticulate systems are used by researcher for formulation of, floating drug delivery system. Sharama and Powar developed multiparticulate floating pulsatile drug delivery system using porous calcium silicate and sodium alginate for time and site specific drug release of meloxicam. New technologies are discussed in marketed products. Under Phase I/II Clinical trials, Pulsysa versions of clarithromycin, metronidazole, amoxycillin/clavulanate combination by Advancis Pharmaceutical Corp., Maryland, USA. SUMMARY : SUMMARY Especially disease with chronological pharmacology pulsatile drug delivery system was beneficial. By using any of the approaches described above the pulsatile drug delivery system can be formulated successively. The pulsatile drug delivery system is the best approach for the diseases releated to chronopharmacokinetics. : There is a constant need for new delivery systems that can provide increased therapeutic benefits to the patient. Sustained release formulations are not efficient in treating the disease especially disease with chronological pharmacology for which pulsatile drug delivery system was beneficial Pulsatile drug delivery IS one such system that by delivering drug at the right time, right place, and right amount , hold good premises of benefit to the patients suffering from chronic problems like arthritis,asthma,hypertension etc. Various methodologies are employed for developing pulsatile drug delivery and there are various technologies present in the market based on various methodologies. Pulsatile release systems should be promising in future. CONCLUSION REFERENCES : REFERENCES CONTROLLED DRUG DELIVERY SYSTEM BY N. K. JAIN CONTROLLED DRUG DELIVERY CONCEPT AND ADVANCE BY S.P VYAS WWW.GOOGLE.COM WWW.ASK.COM WWW.AAPSPHARMASCITECH.COM THANK YOU : THANK YOU THANK YOU