coordination compounds as antimicrobial agents

Bioinorganic chemistrycoordination compounds in medicine : 

Bioinorganic chemistrycoordination compounds in medicine Antimicrobial agents Abdelrhman khattab abdelrhmankhattab@gmail.com Supervised by Dr. Aml Fawzy

Microorganisms : 

Microorganisms صورة لمئات الناس بالسل

Slide 3: 

ssadfffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffffdsdf

Slide 4: 

صوره لعالم فى المعمل

Antimicrobial agent : 

Antimicrobial agent Generally It is any substance using against microbes Include disinfectant for non –living objects Antibiotic for living objects

Slide 9: 

Specifically It is a substance that kill or inhibits the growth of microorganisms kill microorganisms called Microcidal Inhibits microorganisms called Microstatic

Antibiotic Definition : 

Antibiotic Definition If microbe Bacteria : anti microbe called antibiotic Fungi : anti microbe called Antifungal Virus : anti microbe called Antiviral Parasite : anti microbe called Anti parasite

Using of coordination in antimicrobial agent : 

Using of coordination in antimicrobial agent Anti bacterial Anti viral

Mode of action : 

Mode of action In virus Occur electrostatic attraction between metal complex &virus Cation of M may penetrate the cell wall and prevent V reproduction Not reproduce DNA ceased virus +

Slide 13: 

For anti viral detection using anti viral assay using real time PCR صورة للبسر

Slide 14: 

Bacteria Cis –platinum movie

Slide 15: 

Detect for antibacterial using Disk diffusion method Media differ according bacteria type media bacteria Media loaded with bacteria 18 hr 35-37 °c Bacteria grown Complex load on disk 18 hr 35-37 °c Appear inhibition zone indicate that this complex has antibacterial activity

Slide 16: 

MIC (minimal inhibition zone ) The lowest conc. of the complex that complete inhibit the microbe MIC50 :the conc. of the complex that kill 50% of the microbe MIC90 :the conc. of the complex that kill 90% of the microbe

Slide 17: 

The activity of complex depend on charge distribution size shape redox potentials of metal chelates

Examples : 

Examples Ex1 :Antibacterial [Fe(Me4Phen)3]+2 and [Ru(Me4Phen)2(acac)]+ against Staphyloccus pyrogenes

Slide 19: 

Ex2:Antibacterial Structure of schiff-thiol and oxime thiole ligands in the preparation of Co(ll), Zn(ll) , Cd(ll) , Hg(ll) complexes

Slide 20: 

structure of Schiff –thiol and oxime-thiol ligands used in the preparation of Co (II), Ni (II), Zn (II), Cd (II) and Hg (II) complexes.

Slide 21: 

The result indicate the following : The Metal complexes show more increased activity than the corresponding ligands chelation reduces the polarity of metal ion because of partial sharing of it is positive charge with the donor group of ligands Increase the lipophilic character of the metal complex ( which is nessary to cross the permiability barrier of cells )

Slide 22: 

п-electron delocalization in compound exhibite more toxicity than corresponding compound lack п-electron Metal complex with thiols containing additional hydroxyl groups exhibite increased biological activity

Slide 23: 

The general trend of growth inhibiton agaist all the bacteria is found to be in order Ni > Cu > Co > Zn All Hg show more biological activity due to highly reduced polarity of the metal ion which has strong affinity for sulphur

Slide 24: 

Ex3:Anti viral aromatic and Heteroaromatic thiosemicarbazones aganist small pox as 1- methylisatin β-thiosemicabazone

Slide 25: 

Ageneral structure of aromatic and hetero aromatic thiosemicarbazones H S

Recently : 

Recently Prospects for new antimicrobial based on N,N-dimethyl biguanide complexes against S.aureus , P.aeruginosa

Slide 27: 

Zn(ll) > Mn (ll) the most antimicrobial activity with low MIC values

Slide 28: 

Thanks