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Sheed Suhrawardy Medical College Hospital, Dhaka-1207, Bangladesh. Basic of From - OSTEOMYELITIS CME ON -PowerPoint Presentation: Presenting By- Dr. Golam Mahamud Suhash , From Department Of Orthopedic & Traumatology , Shaheed Suhrawardy Medical College Hospital, Dhaka-1207. Bangladesh. Prepared By- Dr. Md Nazrul Islam MBBS, M . sc. (B M E). OSTEOMYELITISPowerPoint Presentation: Osteomyelitis may be defined as an acute or chronic inflammatory process of bone, bone marrow and its structure secondary to infection with micro organisms. 11/14/2012 3 Definition of Osteomyelitis:PowerPoint Presentation: 11/14/2012 4 The Cierny-Mader staging system is used – It is determined by the status of the disease process regardless of its aetiology, regionality or chronicity. It takes into account the state of the bone, the patient's overall condition and factors affecting the development of osteomyelitis. Staging Of Osteomyelitis:PowerPoint Presentation: 11/14/2012 5 1 : Medullary osteomyelitis (infection confined to the bone surface) Stage. 2: Superficial osteomyelitis (contiguous type of infection)Stage . 3: Localised osteomyelitis – (full-thickness cortical sequestration which can easily be removed surgically)Stage . 4: Diffuse osteomyelitis (loss of bone stability, even after surgical debridement). Anatomical Staging Of Osteomyelitis:PowerPoint Presentation: In Newborns (younger than 4 mo) - S. aureus , Enterobacter species, and group A and B Streptococcus species In Children (aged 4 mo to 4 y ) - S. aureus , group A Streptococcus species, Haemophilus influenzae , and Enterobacter species In Children, adolescents (aged 4 y to adult) - S. aureus (80%), group A Streptococcus species, H. influenzae , and Enterobacter species In Adult - S. aureus and occasionally Enterobacter or Streptococcus species In Sickle Cell Anemia Patients - Salmonella species Fungus also cause s osteomyelitis . 11/14/2012 6 Etiological agents:PowerPoint Presentation: Hematogenous -common in children Direct inoculation (usually traumatic, but also surgical) Local invasion from a contiguous infection (usually decubitus ulcer or periodontal disease) 11/14/2012 7 PathogenesisPowerPoint Presentation: Hematogenous osteomyelitis highest in the first two decades of life. < 5 years of age. In adult- Haematogenous is less common but they suffered due to debility,disease (diabetes mellitus)drugs( immunosuppresion ). 11/14/2012 8 Pathogenesis(cont….)PowerPoint Presentation: Discontinuous endothelium of distal metaphyseal vessels ----passage of bacteria through these gaps ---deposition Trauma or emboli lead to occlusion of the slow-flowing sinusoidal vessels, further establishing a nidus for infection. Metaphyseal capillaries--- lack phagocytic lining cells Sinusoidal veins contain - inactive phagocytic cells. Necrosis of cortical bone and marrow occurs. Exudate under pressure is forced through the Haversian systems and Volkmann canals and into the cortex of the bone. 11/14/2012 9 Pathogenesis(cont….)PowerPoint Presentation: Pus spreads into the bone's blood vessels, impairing their flow, and areas of devitalized infected bone, known as sequestra , form the basis of a chronic infection.Often , the body will try to create new bone around the area of necrosis . The resulting new bone is often called an involucrum .On histologic examination, these areas of necrotic bone are the basis for distinguishing between acute and chronic osteomyeliti s . 11/14/2012 10 Pathogenesis(cont….) Newborns- : Newborns- Joint involvement is common Nutrient metaphyseal capillaries perforate the epiphyseal growth plate, particularly in the hip, shoulder, and knee thin metaphyseal cortex. 11/14/2012 11Factors That Turn Acute Bone Infection to Chronic Osteomyelitis:: Factors That Turn Acute Bone Infection to Chronic Osteomyelitis: 11/14/2012 12 Trauma ( orthopaedic surgery or open fracture) Prosthetic orthopaedic device Diabetes Peripheral vascular disease Chronic joint disease Alcoholism Intravenous drug abuse Chronic steroid use Immunosuppression Tuberculosis HIV and AIDS Sickle cell disease Presence of catheter-related blood stream infection .PowerPoint Presentation: Signs and symptom Temperature >102ºF long-lasting pain, Decreased range of motion in the case of joint involvement. local warmth, tenderness, swelling 11/14/2012 13 DiagnosisPowerPoint Presentation: Aspiration of pus and send for culture W.B.C. CRP and ESR Blood for culture Plain films, bone scintigram,ultrasound,CT Scan and MRI Even a biopsy all show positive results 11/14/2012 14 Diagnosis(cont….)PowerPoint Presentation: Elevations in the peripheral white blood cell count (WBC), Erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) in children with hematogenous osteomyelitis are variable and nonspecific Blood culture is positive in half of cases. 11/14/2012 15 Laboratory findings:PowerPoint Presentation: Lytic and sclerosis, indicating chronic infection. Periosteal new bone formation, with compatible clinical findings 11/14/2012 16 Plain radiographs shows-Within three to seven days-: Within three to seven days- interposed translucent fat planes within muscle are obliterated by edema fluid. Periosteal elevation or thickening may represent new bone formation, pus, or reactive edema from adjacent soft tissue infection 11/14/2012 17PowerPoint Presentation: Age --- neonates, bone destruction is often apparent by the 7th to 10th day of illness Type of bone ---Long tubular bones show signs two to three weeks earlier than membranous or irregular bones. plain films of the pelvis -- not helpful 11/14/2012 18 TimingPowerPoint Presentation: Radiographic evidence of bone destruction finally becomes apparent by 10 to 21 days. 11/14/2012 19 TimingMagnetic resonance imaging: Magnetic resonance imaging Modality of choice Accurate identification of subperiosteal or soft tissue collections of pus. no radiation. Excellent anatomic detail and differentiation among soft tissue, bone marrow, and bone signal from infected bone marrow can also be enhanced with intravenous gadolinium contrast – when plain films are no rmal 11/14/2012 20Scintigraphy: Scintigraphy Sensitivity (84 to 100 percent) and specific (70 to 96 percent) Usually readily available, Relatively inexpensive, Does not require sedation in young children. May not perform as well in neonates Accuracy in children in 90% 11/14/2012 21PowerPoint Presentation: CT preferred over plain films Planning the surgical approach to debridement of sequestra Evaluating the patient being treated for osteomyelitis 11/14/2012 22 Computed tomographyDifferential diagnosis -: Differential diagnosis - Cellulitis \ Necrotizing myositis Suppurative Arthritis Rheumatism Sickle cell crisis Gaucher,s disease Ewing,s sarcoma 11/14/2012 23Management And Treatment Of Osteomyelitis:: Management And Treatment Of Osteomyelitis: General principles- Early clinical suspicion, confirmation through imaging and microbiological tests and prompt treatment are the keys to a successful outcome. Analgesia (and limb splinting if a long bone is involved) is an important part of symptom control. Exact treatment varies according to the bones involved, the severity of the infection and the immune status of the patient. Surgery may be needed to debride the bone and close any defects. 11/14/2012 24PowerPoint Presentation: In acute osteomyelitis - The principle of treatment are- 1.General supportive treatment Analgesic for relieve pain I/V fluid(fever with shock,septicaemia ) 2.Spintage of the affected part 3.Antibiotics(oral/intravenous)-It should be started immediately not waiting for culture of blood and pus 11/14/2012 25 Management And Treatment Of Osteomyelitis (Cont.):PowerPoint Presentation: Antibiotics- In older children who have probably s.aureus infection use I/V flucloxacillin and fusidic acid for 1 to 2 weeks then orally 3 to 6 wks. In children under 4 years who have high incidence of haemophilus influenza use cephalosporins ( cefuroxime or cefotaxime ) either I/V or orally.Alternatively also use combination of amoxycillin and clavulanic acid 4.Drainage-if necessary 11/14/2012 26 Management And Treatment Of Osteomyelitis: (con.)PowerPoint Presentation: If treatment is delayed or the organism insensitive to the chosen antibiotics arise some complications- 1. Metastatic infection 2. Suppurative arthritis 3. Altered bone growth 4. Chronic osteomyelitis 11/14/2012 27 Complications of acute osteomyelitisTreatment(cont…): Treatment(cont…) In chronic osteomyelitis - Treatment options are- 1. Antibiotics- Chronic infection is seldom eradicated by antibiotics alone.Fusidic acid,clindamycin and cephalosporins are good examples. 2. Local treatment- If sinus present-need simply dressing Colostomy paste used to stopped excoriation of skin. In acute abscess-need urgent incision and drainage but it is temporary. 11/14/2012 28Management And TreatmentOf Osteomyelitis (Cont.):: Management And TreatmentOf Osteomyelitis (Cont.): 3 . Operation-procedures are: 1.Saucharization and curettage 2.Gentamycin impregnated beads 3.Papineau technique and muscle flap transfer. 4.Ilizarov method of bone transporting. 11/14/2012 29MONITORING RESPONSE TO THERAPY: MONITORING RESPONSE TO THERAPY A reduction in fever and pain, as well as increased comfort with movement are expected within seven days, and may be seen in toddlers in as little as three to five days. Persistent elevation or prolonged decline in ESR or CRP. The ESR should have substantially decreased (by 20 percent or more) by the end of the first week of therapy, with a 50 percent decline in CRP. continue to decline during the second week of treatment. CRP returns to normal in 10 days or less in most patients. 11/14/2012 30OUTPATIENT THERAPY-: OUTPATIENT THERAPY- Treatment with intravenous antibiotics for periods of seven days or less, followed by oral therapy, appears to be as successful as longer initial parenteral courses Followup one- to two-week intervals --monitored clinical improvement, -- complications related to high-dose antibiotic therapy, such as cytopenia , antibiotic associated diarrhea, and pseudomembranous enterocolitis . ESR, complete blood count, and biochemical profile, including liver function tests at each visit. drug levels for those children receiving oral therapy A radiograph should be repeated at the end of therapy. 11/14/2012 31Most Common Complications Of Acute Osteomyelitis:: Most Common Complications Of Acute Osteomyelitis: Bone abscess Septic Arthritis Bacteraemia Fracture Growth arrest Loosening of the prosthetic implant Overlying soft-tissue cellulitis Chronic infection 11/14/2012 32Prognosis Of Osteomyelitis:: Prognosis Of Osteomyelitis: This is variable depending on the number of risk factors and the patient's general condition (see Staging above). Outcome is best if treatment is started 3-5 days after onset of the infection. Timely diagnosis and intervention in an otherwise well patient should lead to full recovery, although follow-up over several months will be required to monitor for relapse. 11/14/2012 33General Guide Lines For Evaluation & Management of Osteomyelitis:: General Guide Lines For Evaluation & Management of Osteomyelitis : 11/14/2012 34Incepta Pharmaceuticals Ltd. Dhaka, Bangladesh. : Incepta Pharmaceuticals Ltd. Dhaka, Bangladesh. Prof. Dr. Shamimul Haq Associate Prof. Dr . P C. Debenath Associate Prof. Dr. Ziaul Haq Associate Prof. Dr. Hafizur Rahman Assistant Prof . Dr . Kazi Shamim uzzaman Special Thanks to - &PowerPoint Presentation: THANK YOU ALL You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.