Taste Masking of Bitter Drugs by Priyanka Birari

Views:
 
Category: Education
     
 

Presentation Description

No description available.

Comments

Presentation Transcript

TASTE MASKING OFBITTER DRUG : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 1 TASTE MASKING OFBITTER DRUG RESEARCH STUDENT : Miss.Priyanka E.Birari T. Y. B. Pharm RESEARCH GUIDE : Mrs.Vandana R.Daga M.Pharm.(Pharmaceutics) SSDJ College of Pharmacy,Chandwad.Nashik

Contents : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 2 Contents INTRODUCTION TASTE MASKING METHODS OF TASTE MASKING SPRAY DRYER DRUG PROFILE POLYMER PROFILE MATERIALS & METHODS OBJECTIVE & PLAN OF WORK RESULT BIBLIOGRAPHY

Introduction : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 3 Introduction Taste Masking Need of taste masking Ideal Taste Masking Process and Formulation

Method Of Taste Masking : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 4 Method Of Taste Masking Coating of drug particles with inert agents Molecular complexes of drug with other chemicals Taste masking by formation of inclusion complexes Solid dispersion system Micro encapsulation Multiple Emulsions Pro drugs Mass extrusion method (Dispersion coating) Ion Exchange Resin

Spray Dryer : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 5 Spray Dryer

Spray Dryer System Consists of : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 6 Spray Dryer System Consists of Filter Air heater Air distributor Drying chamber Collection bottle First cyclone First collected pot Second cyclone Second collected pot Scrubber Aspiratory assembly Electronic control panel

Mechanism of Spray Dryer : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 7 Mechanism of Spray Dryer Co current flow Counter Current flow Disc Atomizer (Rotary wheel)

Ambroxol hydrochloride (I.P.) : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 8 Ambroxol hydrochloride (I.P.) Structure IUPAC Proprietary names Description Solubility Ambroxol indication Ambroxol contraindication Ambroxol side effect Precaution Mode of action Indication and dosage Storage How to supplied

Hydroxypropyl methyl cellulose : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 9 Hydroxypropyl methyl cellulose Nonproprietary name Synonym Chemical name Empirical formula structural formula Functional category: Application in pharmaceutical formulation or technology: Description

Polyvinylpyrrolidone : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 10 Polyvinylpyrrolidone Nonproprietary names Synonyms Chemical name Empirical formula and molecular weight Structural formula Functional category Applications Description

Carbomer : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 11 Carbomer Nonproprietary name Synonym Chemical name Empirical formula structural formula Functional category: Application in pharmaceutical formulation or technology: Description

Materials and Methods : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 12 Materials and Methods Drug candidate Ambroxol hydrochloride Polymers selected: Hydroxy propyl methyl cellulose [HPMC], Polyvinyl pyro1idoie [PVP], Carbomer Apparatus used for study 1. Spray dryer (Lu-222) 2. U.V. spectrophotometer 3. Magnetic Stirrer.

Objective and Plan of work : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 13 Objective and Plan of work Objective The present study was undertaken to formulate & evaluate a bad\bitter taste masked drug Plan Of Work 1. Analysis of drug as per pharmacopoeia for a. Description b. Melting point c. UV spectroscopy 2. Construction of Beer- Lambert’s Plot 3. Formulation of micro particles 4. Evaluation of micro particles for a. Percentage yield value b. Percentage encapsulation efficiency c. Percentage drug release.

Identification & Characterization of Drug : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 14 Identification & Characterization of Drug Physicochemical properties a) Organoleptic properties and description b) Melting point: c) U. V. Spectroscopy Construction of Beer-Lambert’s plot

Construction of Beer-Lambert’s plot : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 15 Construction of Beer-Lambert’s plot

Evaluation of microspheres : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 16 Evaluation of microspheres Percent yield value Encapsulation efficiency In vitro drug release study from Ambroxol hydrochloride microspheres

In vitro drug release : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 17 In vitro drug release

Results : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 18 Results

Bibliography : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 19 Bibliography Martindale,The complete drug reference,Published by the pharmaceutical press,33 edition Page no.416. A.R. Pardkar, Pharmaceutical engineering, Published by Nirali Prakashan, 4th edition, Sept.2002, Page No. 252. C.V.S. Subramanyam, Pharmaceutical engineering, Published by vallabh prakashan, 1st edition, 2004, Page No. 294. Vidgreen P., Vidgreen M., Arppe J, Hakuli T, Lainc, In vitro evaluation of spray dried, mucoadhesive microspheres for nasal administrative. Arthur H. Kibbe, Handbook of Pharmaceutical excipients, 3rd edition, Page No. 252, 433. Journal of Pharmaceutical Science, Volume- 97, Page No. 303. Journal of Pharmaceutical Science, Volume- 97, No. – 8, Jan – 2008, Page No. 3153. Lebutima spray drier manual (Lu-222).

Bibliography : 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 20 Bibliography Raymond, ( Rowe, Paul, J. Sheskey) and sian, C. owen, Handbook of pharmaceutical excipients, 5th edition, 2006, Page no. 346, 611. Indian Pharmacopoeia, 2008, Published by controller of publication , Delhi. British Pharmacopoeia, 2005, Published by The stationary office on health of medicine and Healthcare products, regulatory agency, Page No. 670. United states pharmacopoeia, NF, The official compendia of standards, by authority of united states, 23rd edition, Page No. 667. Leon Lachaman, Herbert A. Liberman, Joseph C. Kanig, “The theory and practice of Industrial pharmacy”, Third edition, Published by varghese publishing house, 1990, P.no.- 60, 61. www.google.com. www.sciencedirect.com www.pubmed.com.

Slide 21: 

Thursday, March 03, 2011 Taste & Masking of Bitter Drug 21 Thank You!!!!

authorStream Live Help