Slide 1: Ayurvedic Dosage Form
& Their
Standardisation Seminar on … Presented By : Jayprakash S. Nogaja Contact-jpnogja@rediffmail.com Contact No ;-9766764132,9420090124
Slide 2: Great role in medicinal, nutraceuticals and cosmetics products . Definition :
Ayurvedic medicines are all the medicines intended for internal or external use, for or in the diagnosis treatment, mitigation or prevention of disease or disorder in human beings or animal and manufactured exclusively in accordance with the formulae described in the authorative books of Ayurvedic Systems of medicine specified in the first schedule of the Drug and Cosmetic act 1940.
Slide 4: Solid Dosage forms
Slide 5: Vatika Medicament is
in tablet form prepared
by
compressin
Slide 6: Preparation of gutika Gutika Medicament is in the
Pills form.
Slide 7: Preparation of Churna Churna It is Fine powder of drug or drugs.
Types :
Simple
Compound
Ash containing
Slide 8: Bhasma These are the preparation containing ash which are obtained through the process of incineration of crud drug treated with metalic or non metalic minerals(gold,silver,zinc
,copper)reagents or extract or plant jouice or amimal derived substances like shells & horns in closed crusibles or in pits with cow dung cakes
Slide 9: Preparation of Ksharas Ksharas Alkaline basic substance obtain by dissolving ash in water
It is hygroscopic , deliquicent in nature
Salty
Stable for long period
Slide 10: Preparation of sattva Sattva Dried water extract of plant material Nassas Fine powdered dried blown into nostril or by aqueous or oily preparation by dropper it is instiled
Slide 11: Semisolid Dosage forms
Slide 12: Preparation of Avaleha Avaleha It is sugar based semisolid preparation for oral use.
Slide 13: Lepa Lepa are semisolid preparation for external application in the form of paste Vegitable powders are stable for 1 month but with mineral stable long last
Slide 14: Preparation of matras Matras It is highly potent,sticky preparation applied to tongue where from drug is absorbed
Slide 15: Kalka Fresh or dried crude drug is powdered poured in hot or cool water to get vary fine paste is called is Kalka. Swarasa Kalka is expressed through the layers of cloths to produce thick juice generally crushed leaves or root of herbs are used Praash IT is highly palatable preparation used for refreshing or rejuvination of the body.
Like jams
Slide 16: Liquid Dosage Forms
Slide 17: Preparation of Arishta Arishta These are liquid ayuruedic preparation prepared by process of fermentation (sandana process)
Slide 18: Preparation of Asava Asava These are liquid ayuruedic preparation prepared by process of fermentation (sandana process)
Slide 19: Preparation of Arka Arka It is liquid formulation obtained by distillation of drug having characteristic odour
Slide 20: Preparation of Kvatha (Decoction ) Kvatha (Decoction ) It is liquid formulation obtained by the method of decoction meant for either oral administration or
external use Dravaka It is prepared by distillation with out adding any fluid .
It should be stored in glass bottles
Slide 21: Preparation of Taila Taila (medicated oil ) It is lipophilic liquid prepared
by dissolving or extracting medicinal substance
with oils Netrabindu It is prepared by dissolving specified crude drug in water,
honey & used as eye drop.
Slide 22: Standardisation of
Ayurvedic Dosage Forms
Slide 23: 1 .
Taxonomical Estimation
Authentication of drug material
2 .
Organoleptic/sensary Evaluation
Colour
Odour
Appearance
Powder partical size Distribution
Powder flow
Clearity Parameters For Evaluation
Slide 24: 3 .
Foreign Matter
Of Foreign Plant
Of Own Plant
Of Other animal
Mineral 4 .
Microscopic Evaluation
Qualitative
Palisade Ratio
Vein Islet
Vein Termination
Stomatal Index
Stomatal Numbre
Slide 25: Quantitative
Lycopodium Spore count method
Starch Grain
Calcium Oxalate Crystals 6 .
Chromatographic & other Methods
TLC & HPTLC
HPLC
UV Spectroscopy
GC-MS
Fluorimetry
Slide 26: 5 .
Physicochemical Parameters
PH
Disintegration time
Friability
Hardness
Sedimentation Rate
Solubility
Viscosity
Ash Values
Total Ash
Acid insoluble Ash
Water soluble
Sulphated Ash
Extractive Values
Water soluble
Ethanol soluble
Ether Soluble
Slide 27: Volatativitiy
Oil related values
Saponificable matter
Acid Value
Ester Values Swelling Index
Foaming Index
Melting Range
Optical Rotation
Moisture content
Loss on Drying
Aziotropic mixture method
Karl Fischer Method
Spectroscopic method
Electrometric Method
Slide 28: 7 .
Pharmacological Parameters
( Bioassays to estimate potency )
Bitterness
Astringent Activity
Antimicrobial Activity
Hemolytic Activity
Antioxidant Activity
Nitric oxide Scavenging Activity
Slide 29: 8 .
Toxicological
(Establishment of Safety )
Limit Tests
Pesteside containt
Heavy metals Containt
Aflotoxin
Radio active Contaminant
Bioburdan
Bacterial
Pathogenic
Non Pathogenic
Fungal
Slide 30: current Senario Dabur India Ltd. - 650 million dollars Sri Baidyanath Ayurvedic Bhawan Ltd. -350 million dollars Zandu Pharmaceutical Works -45 million dollars The Himalaya Drug Company – 500 million dollars The Emami Group, -110 million dollars There are today 30 companies doing business of a million dollars or more per year (September 2003)