Genetik_Einfuehrung_WS1011

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Einführung in die Genetik : 

Einführung in die Genetik Prof. Dr. Kay Schneitz (EBio Pflanzen) http://plantdev.bio.wzw.tum.de schneitz@wzw.tum.de Prof. Dr. Claus Schwechheimer (SysBiol Pflanzen) http://wzw.tum.de/sysbiol claus.schwechheimer@wzw.tum.de

Einführung in die Genetik : 

Einführung in die Genetik VO, 2 SWS / 3 ECTS im WS Dienstags, 08.30 - 10.00 Uhr, HS16, WZW Übung 1 SWS / 1 ECTS in SFerien, LV-Nr 2401237000 14. 03. - 18. 03. 2011, 09.00 - 17.00 Uhr,HS12, WZW, PD Dr. Erich Glawischnig, Dr. Lilla Römisch-Margl (Genetik) http://www.tum.de/genetik egl@wzw.tum.de, l.roemisch-margl@wzw.tum.de

Prüfung : 

Prüfung 18. 03. 2011 HS 21, WZW, Forst 13.00 Uhr VO + Übung

Prüfungsanmeldung : 

Prüfungsanmeldung TUMonline zwingend!!! https://campus.tum.de/tumonline/webnav.ini myTUM-Kennung / Password Wenn angemeldet --> Rückzug nur mit Attest (Prüfungsamt), ansonsten --> nicht angetreten und eine 5.0 !!

URLs... : 

URLs... Generell: http://plantdev.bio.wzw.tum.de http://wzw.tum.de/sysbiol PPT/Podcast (.ppt, .mp3, .m4v) files http://plantdev.bio.wzw.tum.de/anmeldung http://www.wzw.tum.de/sysbiol/index.php?id=10 Noten https://campus.tum.de/tumonline/webnav.ini myTUM-Kennung (MWNID)/Password

Downloads : 

Downloads user: gregor password: mendel http://plantdev.bio.wzw.tum.de/anmeldung http://www.wzw.tum.de/sysbiol/index.php?id=10

Literatur : 

Literatur Introduction to Genetic Analysis. 9th Edition.Griffiths, A.J.F., Wessler, S.R., Lewontin, R.C., Carroll, S.B. (2009). WH Freeman and Company, New York, USA. Genetics Essentials: Concepts and Connections. Pierce, B.A. (2010) WH Freeman and Company, New York, USA. Molecular Biology of the Cell, 5th Edition.Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K., Walter, P. (2008) Garland Science, Taylor & Francis Group, UK

Entwicklungsbiologie der Pflanzen : 

Entwicklungsbiologie der Pflanzen http://plantdev.bio.wzw.tum.de Prof. Dr. Kay Schneitz Organogenese pattern formation organ shape organ size Bruguiera gymnorhiza Magnolia stellata

Shaping Beauty : 

Shaping Beauty Pattern Formation Organ Shape Organ Size B. Enugutti A. Mueller L. Fulton K. Beckenbauer S. Brameyer P. Vaddepalli D. Wozny M. Oelschner C. Skornia Signal transduction: SUB / SRF4 pathways Sexual reproduction Ovule development

SUB: inter-cell-layer cross-talk : 

SUB: inter-cell-layer cross-talk Morphogenesis Auxin homeostasis Cell Wall Stress Cell Fate ? QKY Ca2+ membranetrafficking? SUB AN ZET ALADIN KGAP ARF-GAP CaMBP LRR-RLK ...more ERECTA ColMod2 GAPN AN SUB QKY ZET ? cell wall?

Organ size: the SRF4 signaling pathway : 

Organ size: the SRF4 signaling pathway DAEUMLING ?? Cell Size Translation SUI1 L3 rProtein Organ Size SET-domain Y2H candidates Chromatin WINZLING KLITZEKLEIN

Molecular Methods : 

Molecular Methods Molecular Biology, Cell Biology, Microscopy (confocal, SEM, fluorescence, in vivo), Biochemistry, Bioinformatics

Auf gehts... : 

Auf gehts...

Why Genetics? : 

Why Genetics? ... and what is it anyway?

Offspring of mice are mice : 

Offspring of mice are mice Sea Urchin (Seeigel) Mouse Fucus

Heritable (genetic) variation within a species : 

Heritable (genetic) variation within a species

Genetics : 

Genetics laws and molecular basis of inheritance (Vererbung) of genes (Erbanlagen) laws and molecular basis of the formation (Ausbildung) of characters/traits (erbliche Merkmale) from molecules to populations

Modern genetics : 

Modern genetics Gregor Mendel (1822-1884) 1866 Experimental results of controlled crosses (Kreuzungen) Existence of “discrete factors” that carried the information on development from parent (Eltern) to offspring (Nachkommen) 1900 Rediscovery of Mendelian RulesHugo de Vries, Carl Correns, Erich Tschermak

Crosses between strains with inherited variation : 

Crosses between strains with inherited variation Pea (Erbse)

From body to cells to chromosomes to genes : 

From body to cells to chromosomes to genes

Molecular Basis of Genetic Information : 

Molecular Basis of Genetic Information

Structure of DNA : 

Structure of DNA

DNA replication : 

DNA replication

Transcription/Translation (Eukaryote) : 

Transcription/Translation (Eukaryote)

Genetics in Biology : 

Genetics in Biology Transmissiongenetics Moleculargenetics Populationgenetics

Genetic analysis: a powerful experimental strategy : 

Genetic analysis: a powerful experimental strategy induce mutation (mutagens: X-ray, certain chemicals) localize on chromosome combine mutations in different ways analyze different developmental, physiological, biochemical processes 1926: X-rays induce inherited mutations (Muller)

Model organisms : 

Model organisms

Model systemArabidopsis thaliana : 

Model systemArabidopsis thaliana Ackerschmalwand Genetische Vorteile - kleine Pflanze - grosse Anzahl von Nachkommen pro Pflanze - Selbstbestäubung - kurze Generationszeit Molekulare Vorteile - kleines Genom - Genom sequenziert - transformierbar Forschungsgemeinschaft - weltweit (Europa, Japan, USA) - Resourcenzentren (DNA, Samen etc)

The program of genetic investigation : 

The program of genetic investigation Key to a genetic analysis of a biological property Examination of the effects of mutations Forward genetics vs reverse genetics

Genetic dissection : 

Genetic dissection Enzymes Genes A B C A B C Biosynthetic pathway α β γ δ

Genetic dissection : 

Genetic dissection Enzymes Genes A B C A B C Biosynthetic pathway α β γ δ

Genes, the environment, and the organsism : 

Genes, the environment, and the organsism Genotype vs Phenotype

1. Purely genetic variation : 

1. Purely genetic variation between species within species

2. Variation solely due to environment : 

2. Variation solely due to environment

3. Variation due to gene-environment interactions : 

3. Variation due to gene-environment interactions

4. Variation due to developmental noise : 

4. Variation due to developmental noise

Genotype vs Phenotype : 

Genotype vs Phenotype inherited is not inherited more or less constant throughout life essentially unchanged by environment GT PT often changes continually throughout life

Genetics in Biology : 

Genetics in Biology Transmissiongenetics Moleculargenetics Populationgenetics

Developmental genetics : 

Developmental genetics WT agamous WT antennapedia Arabidopsis Drosophila

Human genetics : 

Human genetics

Molecular basis of albinism : 

Molecular basis of albinism

Evolution : 

Evolution genetic change through time

Genetic diversity and evolution : 

Genetic diversity and evolution

Simple vs filled flowers : 

Simple vs filled flowers Bibernellrose Sutter’s Goldrose agamous (Ath) Recapitulation of Evolution

The “four-winged fly…..” : 

The “four-winged fly…..” Recapitulation of Evolution WT mutant

Genetics and Application : 

Genetics and Application

Breeding: thousands of years of applied genetics : 

Breeding: thousands of years of applied genetics

Green revolution : 

Green revolution

Medicine : 

Medicine Cystic Fibrosis (Mukoviszidose) Defect in CFTR locus (g.332C>T)

Modern biotechnology : 

Modern biotechnology

Fundamental concepts : 

Fundamental concepts Cellsprokaryotic, eukaryotic Genefundamental unit of heredity Allelesmultiple forms of a gene Genotype vs Phenotypegenes confer phenotypes Genetic Informationcontained in DNA and RNA Chromosomesgenes are located on chro Mitosis/Meiosischro separation Central DogmaDNA to RNA to protein Mutationspermanent, heritable changes Multigenic traitse.g. human height Evolution is genetic change

Einführung in die Genetik : 

Einführung in die Genetik Prof. Dr. Kay Schneitz (EBio Pflanzen) http://plantdev.bio.wzw.tum.de schneitz@wzw.tum.de Prof. Dr. Claus Schwechheimer (PlaSysBiol) http://wzw.tum.de/sysbiol claus.schwechheimer@wzw.tum.de

THE END : 

THE END

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