CMV_BALOCHH_FAZALN

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CYTOMEGALOVIRUS (CMV) : 

CYTOMEGALOVIRUS (CMV) HAJRA BALOCH MARCH 1, 2010 PHAR 6115

Slide 2: 

www.princeton.edu/~artofsci.html

PHYSIOLOGY AND STRUCTURE : 

PHYSIOLOGY AND STRUCTURE

PHYSIOLOGY AND STRUCTURE : 

PHYSIOLOGY AND STRUCTURE www.who.int/publications

Pathogenesis and Immunity : 

Pathogenesis and Immunity

Epidemiology : 

Epidemiology CMV infects: 50% - 85% adults 0.5% - 2.5% newborns Opportunistic pathogen www.cdc.gov/Features/dsCytomegalovirus/

Clinical Diseases/Syndromes : 

Clinical Diseases/Syndromes

Clinical Diseases/Syndromes : 

Clinical Diseases/Syndromes http://www.nlm.nih.gov/ Small size Thrombocytopenia Microcephaly Intracerebral Calcification Jaundice Hepatoslenomegaly Rash Hearing Loss Mental Retardation

Clinical Diseases/Syndromes : 

Clinical Diseases/Syndromes 10% - 15% of adolescents infected. Usually asymptomatic May show heterophile negative mononucleosis syndrome Low socioeconomic brackets. Sexually transmitted.

Clinical Diseases/Syndromes : 

Clinical Diseases/Syndromes http://www.nlm.nih.gov/ CMV in the Immunocompromised:

Clinical Diseases/Syndromes : 

Clinical Diseases/Syndromes Figure 53-16 Outcomes of cytomegalovirus (CMV) infections. The outcome of CMV infection depends very heavily on the immune status of the patient.

Laboratory Diagnosis : 

Laboratory Diagnosis Cytomegalovirus-infected cell with basophilic nuclear inclusion body. Typical owl-eye inclusion. (www.microbelibrary.org) CMW infection of cell in urine. (http://www.cdc.gov/cmv/faqs.htm)

Treatment, Prevention, and Control : 

Treatment, Prevention, and Control

Mnemonic : 

Mnemonic

References : 

References "CDC - Cytomegalovirus (CMV): Topic Home." Centers for Disease Control and Prevention. 22 May 2009. Web. 28 Feb. 2010. <http://www.cdc.gov/cmv>. "CMV (cytomegalovirus): MedlinePlus Medical Encyclopedia Image." National Library of Medicine - National Institutes of Health. 1 Nov. 2007. Web. 28 Feb. 2010. <http://www.nlm.nih.gov/medlineplus/ency/imagepages/17110.htm>. "MicrobeLibrary - Cytomegalovirus." American Society For Mircrobiology. 2002. Web. 28 Feb. 2010. <http://www.microbelibrary.org/ASMOnly/details.asp?id=658&Lang=English>. Murray, Patrick R., Ken S. Rosenthal, and Michael A. Pfaller. "Human Herpesviruses." Medical Microbiology. 6th ed. Mosby Elsevier, 2009. 534-37. Print.