RZ

R-Z : 

R-Z Disease-target

Rabies : 

Rabies Obviously viral infection. Antiviral? Not a quick project

Ramsay Hunt syndrome type I : 

Ramsay Hunt syndrome type I Seizures Treated with valproate. / anti-seizure

Raynaud's phenomenon : 

Raynaud's phenomenon Discoloration of the fingers Treat using blood vessel dilation. – ca channel blockers.  (nifedipine) or diltiazem  Angiotensin II receptor antagonists (often Losartan)  Alpha-1 adrenergic blockers such as prazosin  sildenafil (Viagra) improved both microcirculation and symptoms Fluoxetine, a selective serotonin reuptake inhibitor, and other antidepressant medications may reduce the frequency

Laryngeal papillomatosis : 

Laryngeal papillomatosis Caused by HPV – occurs in the throat

Complex regional pain syndrome : 

Complex regional pain syndrome Various treatments used, such as antidepressants, anti-inflammatories such ascorticosteroids and COX-inhibitors such as piroxicam, bisphosphonates, vasodilators, GABA analogs such gabapentin andpregabalin, and alpha- or beta-adrenergic-blocking compounds, and the entire pharmacy of opioids. Although many different drugs are used, there is not much supportive evidence for most of them. This doesn't necessarily reflect evidence that they don't work, just a lack of evidence that they do.

Reiter's Syndrome / Reactive arthritis : 

Reiter's Syndrome / Reactive arthritis Triggered by bacteria Thus treat with antibiotics, or symptomatically for each problem, thus Analgesics, steroids and immunosuppressants may be needed for patients with severe reactive symptoms that do not respond to any other treatment.

Relapsing polychondritis : 

Relapsing polychondritis Deterioration of cartilage Immunosuppressants

Restless legs syndromeaka Wittmaack-Ekbom's syndrome : 

Restless legs syndromeaka Wittmaack-Ekbom's syndrome Irresistable urge to move limbs to relieve uncomfortable sensations dopamine agonists   gabapentin and opioids pergolide, pramipexole, ropinirole, and cabergoline are prefered Restless Legs Syndrome Foundation.

Retroperitoneal fibrosis : 

Retroperitoneal fibrosis proliferation of fibrous tissue in kidneys, aorta, renal tract h glucocorticoids initially, followed by DMARDs  if refractory on steroids

Rett syndrome : 

Rett syndrome Autism spectrum disorder SSRIs Sleep aids Management of other symptoms

Rheumatic fever : 

Rheumatic fever Inflammatory disease after streptococcal infection Treat inflammation:  aspirin or corticosteroids. In Antibiotics for strep

Rocky Mountain spotted fever : 

Rocky Mountain spotted fever Bacterial infection Doxycycline  first choice

Rubella / German Measles : 

Rubella / German Measles Rubella virus, thus vaccines, symptom management

Sandhoff disease : 

Sandhoff disease Lipid storage disorder No good treatment options now Strict diet Anticonvulsants Currently testing N-butyldeoxynojirimycin in mice

Sarcoidosis : 

Sarcoidosis Inflammatory disease with granulomas Corticosteroids, most commonly prednisone,  azathioprine and methotrexate are often used. Rarely, cyclophosphamide has also been used

Schnitzler syndrome : 

Schnitzler syndrome Chronic hives It may respond to immunosuppressant drugs such ascorticosteroids, cyclooxygenase inhibitors, interferon alpha, interleukin 1 receptor antagonists (Anakinra),[3] colchicine, cyclosporineor thalidomide. The hives may respond to treatment with PUVA, and the bone pain may respond to bisphosphonates.

Scleroderma : 

Scleroderma chronic autoimmune disease characterized by fibrosis (or hardening), vascular alterations, and autoantibodies ifedipine, amlodipine, diltiazem, felodipine, or nicardipine. agents such as d-penicillamine, colchicine, PUVA,Relaxin, and cyclosporine. de methotrexate, cyclophosphamide, azathioprine, and mycophenolate

Segawa Syndrome / Dopamine-responsive dystonia : 

Segawa Syndrome / Dopamine-responsive dystonia

Sjögren's syndrome : 

Sjögren's syndrome Immune cells attack and destroy exocrine glands that produce tears and saliva Symptomatic treatment  disease-modifying antirheumatic drugs (DMARDs) such as methotrexate severe complications, corticosteroids or immunosuppressive drugs stimulate salivary flow, such as cevimeline (Evoxac) and pilocarpine

smallpox : 

smallpox Antivirals Vaccination within 3 days of exposure

Smith-Magenis syndrome : 

Smith-Magenis syndrome Developmental disorder, with sleep disorder Manage symptoms  Melatonin supplements and trazodone are commonly used to regulate sleep disturbances. In combination with exogenous melatonin, blockade of endogenous melatonin production during the day by the adrenergic antagonist acebutolol can increase concentration, improve sleep and sleep timing and aid in improvement of behaviour.[4][5]Other medications (such as risperdal)

Spasmodic torticollis : 

Spasmodic torticollis Neurological movement disorder – neck turning symptomatic treatment Dopamine blocking agents Anticholinergic agents , 21% of patients report relief from clonazepam, 11% of patients report relief from baclofen, and 13% benzodiazepines

Spinal muscular atrophy : 

Spinal muscular atrophy Degeneration of motor neurons Some drugs under clinical investigation for the treatment of SMA: Butyrates Valproic acid Hydroxyurea Riluzole Quinazoline495[5]

Stiff person syndrome : 

Stiff person syndrome progressive rigidity Symptomatic treatment muscle relaxants which enhance GABA production, such as benzodiazepines.

Succinic semialdehyde dehydrogenase deficiency : 

Succinic semialdehyde dehydrogenase deficiency Vigabatrin is an irreversible inhibitor of GABA transaminases  Sodium valproate he GABAB antagonist CGP-35348 (3-amino-propyl-(diethoxymethyl) phosphinic acid) h Baclofen (β-p-chlorophenyl-GABA) has some analgesic properties  Taurine is a non-protein sulfur amino acid tha

Aphthous ulcer / Sutton Disease : 

Aphthous ulcer / Sutton Disease Canker sore – painful sore in the mouth Vitamin B12 Anesthetics Corticosteroids Antivirals  Debacterol,   Aphthasol

Sweet Syndrome : 

Sweet Syndrome Skin disease, rapid onset of fever, plaques, neutrophil granulocytes Prednisone is the gold standard Oral potassium iodide or colchicine may induce rapid resolution , indomethacin, e dapsone,doxycycline, clofazimine, and cyclosporine.

Syphilis : 

Syphilis Antibiotics

Tardive dyskinesia : 

Tardive dyskinesia Involuntary repetitive movements as a side effect of long term or high dose dopamine antagonists, such as antipsychotics  tetrabenazine  Zofran  Aricept, Baclofen, Requip and Mirapex. Clonidine

Timothy syndrome : 

Timothy syndrome Physical malformations, including long QT, autism, heart defects Propanolol or beta blockers for heart rhythm Calcium channel blockers for defects in calcium currents

Tinnitus : 

Tinnitus Ringing in the ears Symptom, thus symptomatic treatment Propranolol and clonazepam (arterial anatomic variation A dozen other pharmaceutical treatments (see wikipedia page)

Toxic shock syndrome : 

Toxic shock syndrome Antibiotic treament  clindamycin[20] or gentamicin[21

Toxoplasmosis : 

Toxoplasmosis Parasitic disease Antibiotics …

Trigeminal neuralgia : 

Trigeminal neuralgia Neuropathic disorder. severe pain. Anticonvulsants   Carbamazepine ; second line drugs include baclofen, lamotrigine, oxcarbazepine, phenytoin, gabapentin, and sodium valproate. clonazepam and lidocaine may be effective  antidepressants such as amytriptiline ar  morphine and oxycodone   sumatriptan

Tropical sprue : 

Tropical sprue Tropical sprue is a malabsorption disease commonly found in the tropical regions, marked with abnormal flattening of the villi and inflammation of the lining of the small intestine.  Antibiotics: tetracycline or trimethoprim

Tuberculosis : 

Tuberculosis Bacterial infection, Thus antibiotics

Tularemia : 

Tularemia Infectious disease, baterical Thus antibiotics

Turner syndrome : 

Turner syndrome Absence of entire sex chromosome 1/2500 girls – surprisingly common Symptomatic treatment Growth hormone / androgen Estrogen replacement therapy

Typhoid fever : 

Typhoid fever Bacterial infection Thus antibiotics

Urticaria pigmentosa : 

Urticaria pigmentosa Cutaneous mastocytosis. Hives or lesions on skin when irritated Treat with anti-allergy medications Nifedipine, Ca++ channel blockers

Cholinergic urticaria : 

Cholinergic urticaria Rash – hypersensitivity to body heat Antihistaminies – H1 receptor antagonists H2 receptor antagonists H1 and H1 together Tricyclic antidepressants are often H1 and H2 antagonists. alpha 1-antichymotrypsin Anabolic Steroids such as Danazol  t anticholinergic agents such as Butylscopolamine are e

Cold urticaria : 

Cold urticaria Cold hives – allergy – from exposure to cold  antihistamines such as Benadryl, Zyrtec, Claritin, Periactin and Allegra Ebastine

Urticaria – Hives (general) : 

Urticaria – Hives (general) H1 receptor antagonists

Varicella zoster virus : 

Varicella zoster virus One of 8 herpese viruses that infect humans Causes chicken pox and shingles Vaccine.

Vitiligo : 

Vitiligo Chronic skin depigmentation  corticosteroid cream.[  immunomodulator creams such as Protopic and Elidel also ca at piperine, a chemical derived from black pepper, c n Ginkgo biloba d that L-phenylalanine used with phototherapy,

Von Willebrand disease : 

Von Willebrand disease Coagulation abnormality, common dEsmopressin acetate to raise patient’s plasma levels of vWF

Vaginitis : 

Vaginitis Topical antibiotics and/or antifungals Antihistamines, cortisone Estrogen cream

Waldenström's macroglobulinemia : 

Waldenström's macroglobulinemia Cancer of white blood cells. Phase II - There are over 100 active trials studying different interventions.[51] Interventions include either individually or combinations ofFludarabine, Perifosine, Bortezomib, Rituximab, Sildenafil citrate, CC-5013, Thalidomide, Simvastatin, Campath-1H,Dexamethasone, Antineoplaston, Beta Alethine, Dolastatin 10, Cyclophosphamide, Yttrium Y 90 Ibritumomab, ABT-263,Ofatumumab, Enzastaurin and Denileukin diftitox.

Wegener's granulomatosis : 

Wegener's granulomatosis corticosteroids   antibiotic co-trimoxazole   methotrexate and steroids  intravenous cyclophosphamide with steroids azathioprine and steroids cyclophosphamide with pulsed methylprednisolone

Leptospirosis : 

Leptospirosis Bacterial zoonotic disease. Thus antibiotics