logging in or signing up Biocompatible micro emulsion aSGuest35792 Download Post to : URL : Related Presentations : Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Uploaded from authorPOINT lite Insert YouTube videos in PowerPont slides with aS Desktop Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 1188 Category: Science & Tech.. License: All Rights Reserved Like it (1) Dislike it (0) Added: January 13, 2010 This Presentation is Public Favorites: 0 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript Biocompatible microemulsion : Biocompatible microemulsion Submitted to: UNIVERSITY OF PUNE Guided by: Submitted by: Mr.SANTOSH. P. BAHIRAT UNNATI N. PATEL (M.PHARM in Q.A.) (T.Y.B.PHARM) S.T.E.S. Smt. Kashibai Navale college of pharmacy introduction : introduction What is Microemulsion? What is Biocompatible Microemulsion? - Having no toxic effects on biological function - Broaden their application - expand modes of their administration - solve absorption problems. - For biocompatible microemulsion mainly w/o emulsion system is used NEED OF STUDY : NEED OF STUDY Powerful tools for the formulation of poorly soluble pharmaceutical active ingredients, Droplet size of microemulsion-below 0.15 micron that can absorbs readily enhances the physical stability and chemical stability of drug itself also. PBCA nanocapsules dispersed in a biocompatible microemulsion to facilitate the absorption of insulin. W/O type are of particular interest in biotechnology- ability to solubilize enzymes in the water domain without denaturation or loss of activity. NEED OF STUDY OBJECTIVES : OBJECTIVES To study Various routes of administration. Excipients used for preparation of biocompatible microemulsion. Manufacturing process for biocompatible microemulsion. Stability for biocompatible microemulsion. Target drug delivery system for biocompatible microemulsion. Review of literature : Review of literature Types of Microemulsion The two basic types of microemulsions. Slide 6: Characteristics of Biocompatible Microemulsion. Excipients used in Biocompatible Microemulsion. Slide 7: Lecithin used as natural emulsifier Synonyms- Phosphatidylcholine Description- Lecithin is a phospholipid, a class of compounds that make up cell membranes throughout the body. Lecithin is obtained for commercial purposes from seeds from which oil is produced (in particular soy seed) and from egg yolk. Uses- widely used as an emulsifying agent In Margarine production process to decrease surface tension and obtain a good distribution of the aqueous phase Slide 8: Intravenous Taxol Microemulsion Lecithin 1.5 Poloxamer 188 1.5 Ethyl oleate 2.0 Triacetin 50.0 Taxol 1.0 Water 44.0 Slide 9: Stability study for Biocompatible Microemulsion 1.Creaming and stokes’ law Those factors that find importance in the creaming of an emulsion are related by Stokes’ law. Following equestion show stokes’ law. υ= d2( ρs -ρ0 )g 18η0 2.Flocculation 3.Coalescence and breaking 4.Phase inversion Slide 10: Ternary phase diagram Ternary phase diagram comprising water/amphiphile/oil. (a)water-in-oil microemulsion; (b)oil-in-water microemulsion; (c)bicontinuousregion; (d and e)biphasic region (coarse emulsion). Slide 11: Manufacturing process of Biocompatible Microemulsion Slide 12: Quality control of microemulsion Determination of globule size and particle count Determination of viscosity Determination of phase separation Determination of electrophoretic properties Slide 13: Target drug delivery system for Microemulsion They can be used to increase the bioavailability of drug poorly soluble in water by incorporation of the drug into the internal phase. Etopoxide was rapidly lost from the microemulsion particles, whereas 60% of the methotrexate diester remained incorporated in the internal phase o f microemulsion. Microemulsions have also been considered as topical drug delivery systems. Transdermal permeation of water from water-in-oil microemulsions formed from water, octanol, and dioctyl sodium sulfosuccinate, the later functioning as the surfactant. Pharmaceutical application : Pharmaceutical application w/o microemulsion is used for treatment of dry skin and emollient application. It can be administered I.V. for lipid nutrients Both o/w and w/o emulsions have been shown to enhance the oral bioavailability of drugs, including various peptides. Cyclosporin is now available commercially in form of microemulsion. From microemulsion the rate of absorption of cyclosporin is more rapid and less variable than it is with the conventional oily dispersion It is used in enzymatic synthesis where protein can easily be adsorbed. discussion : discussion To summarize, Biocompatible microemulsion are optically isotropic and thermodynamically stable liquid solution of oil, water and amphiphile. The development of “Biocompatible microemulsions” is a relatively new area of research that has generated a large number of in vivo and in vitro studies.As these microemulsion systems are diverse in competition, extensive studies are necessary for their standardization so that these systems could be in the form of “drug formulation” for clinical use. DISCUSSION bibliography : bibliography 1. Herbert A. Lieberman, Martin M. Rieger and Gilbert S. Banker, Pharmaceutical Dosage forms: Disperse system-volume 1,2,3,2nd Edition, Revised & Expanded. 2. Journal of Pharmaceutical Science,Volume 97, No.1,January,2008 3. K Krauel, NM Davies, Shook,Trades- Journal of Controlled Release, 2005- Elsevier. 4. James Swarbrick, ENCYCLOPEDIA OF PHARMACEUTICAL TECHNOLOGY, 3rd Edition, 3rd volume. 5. LEON LACHMAN ,The theory and practice of industrial pharmacy,Varghese publishing house. 6. N K JAIN, Progress in Controlled and Novel Drug Delivery Systems. Thanks to all : Thanks to all You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.