MOD Research May 28 2009 Dr Fleishman with comment

Slide 1: 

March of Dimes Research Mission -- In 15 Minutes or Less Alan R. Fleischman, M.D. Senior Vice President and Medical Director May 28, 2009

The Epidemic of Polio : 

The Epidemic of Polio .

FDR --1938 : 

FDR --1938

March of Dimes : 

March of Dimes From its beginning, the March of Dimes has carried out its mission through programs of research, community services, education, and advocacy

Dr. Jonas Salk – MOD Funding : 

Dr. Jonas Salk – MOD Funding 1955--Vaccine to Prevent Polio

Dr. James Watson – 1950 MOD Grant1962 Nobel Prize : 

Dr. James Watson – 1950 MOD Grant1962 Nobel Prize Drs. Watson and Crick Structure of DNA

March of Dimes Mission : 

March of Dimes Mission The mission of the March of Dimes is to improve the health of babies by preventing birth defects, premature birth and infant mortality.

Birth Defects : 

Birth Defects A Birth Defect is an abnormality of structure, function, or body metabolism present at birth that often results in a physical or mental disability Birth Defects account for nearly 20% (I in 5) infant deaths

Dr. Robert Guthrie -- MOD Grant : 

Dr. Robert Guthrie -- MOD Grant 1959-Test for PKU 1963-MA Tests all Babies

Newborn Screening: MOD Public Health Success Story : 

Newborn Screening: MOD Public Health Success Story

Newborn Screening – 2008MOD Public Health Success Story : 

Newborn Screening – 2008MOD Public Health Success Story By July, 2009: 42 States +DC will screen for all 29 disorders; and All States will screen for 21 or more disorders

Neural Tube Defects (Spina Bifida) : 

Neural Tube Defects (Spina Bifida) Epidemiologic Research shows women need to consume 400 mcg. of Folic acid every day to prevent Neural Tube defects.

MOD Folic Acid CampaignFortification of Cereal-Grain Products : 

MOD Folic Acid CampaignFortification of Cereal-Grain Products 1996 FDA – mandatory fortification of enriched cereal-grain products within two years 1998 Institute of Medicine Committee on Dietary Intakes Report: …women capable of becoming pregnant should take 400 mcg of synthetic folic acid daily … in addition to consuming food folate from a varied diet

Slide 14: 

After Ten Years -- MOD has a Real Impact 26% reduction in Neural tube defects in the U.S. 1,000 U.S. babies each year are born healthy

Prematurity (<37 weeks gestation) : 

Prematurity (<37 weeks gestation) Has increased 10% in the last decade and over 30% in the last 20 years #1 Perinatal Health Challenge Leading cause of infant mortality Leading cause of cerebral palsy, blindness, deafness, and retardation

Patrick Bouvier Kennedy -- 1963 : 

Patrick Bouvier Kennedy -- 1963

Patrick Bouvier Kennedy Respiratory Distress Syndrome : 

Patrick Bouvier Kennedy Respiratory Distress Syndrome Born: August 7, 1963 Gestation: 34 weeks Birthweight: 4lb10oz “The battle for the Kennedy baby was lost only because medical science has not yet advanced far enough…” August 8, 1963

Respiratory Distress Syndrome – SURFACTANT Deficiency : 

Respiratory Distress Syndrome – SURFACTANT Deficiency Premature lungs lack the chemical SURFACTANT and have little air

Dr. T. Allen Merritt –- MOD Grant 1983-1987 : 

Dr. T. Allen Merritt –- MOD Grant 1983-1987 Recovered surfactant from amniotic fluid to treat Respiratory Distress Syndrome (RDS) in premature babies

SURFACTANT given to premature babies ameliorates Respiratory Distress Syndrome : 

SURFACTANT given to premature babies ameliorates Respiratory Distress Syndrome Mortality and complications from prematurity decrease dramatically

Institute of Medicine Report: Preterm Birth: Causes, Consequences, and Prevention, 2006 : 

Institute of Medicine Report: Preterm Birth: Causes, Consequences, and Prevention, 2006 Supported by a grant from the March of Dimes

Institute of Medicine Report: Preterm Birth: Causes, Consequences, and Prevention, 2006 : 

Institute of Medicine Report: Preterm Birth: Causes, Consequences, and Prevention, 2006 United States cost per year: $26.2 Billion

Institute of Medicine Report: Preterm Birth: Causes, Consequences, and Prevention, 2006 : 

Institute of Medicine Report: Preterm Birth: Causes, Consequences, and Prevention, 2006 Selected Priority Areas for Research: Improve National Vital Statistics Data Investigate the etiologies of preterm birth Encourage early ultrasound to establish accurate gestational age Develop indicators of maturational age Improve methods of identifying and treating women at risk for preterm labor Improve quality of care for women at risk for preterm labor

March of Dimes -- Enhancing Research : 

March of Dimes -- Enhancing Research Special Prematurity Research Initiative: 2004-2009 -- ~$15,000,000 General Research Portfolio: 2004-2009 -- ~$90,000,000 Basil O’Connor Young Scholar Awards: 2004-2009 -- ~$30,000,000 International Collaborations: World Health Organization Pre-eclampsia Study PREBIC – Global genome-wide association study on prematurity

March of Dime -- Enhancing Research : 

March of Dime -- Enhancing Research Surgeon General’s Conference on Prevention of Preterm Birth – June, 2008 March of Dimes -- Burroughs Wellcome Research Symposium on Prematurity -- December, 2008 March of Dimes Proposal for NIH Sponsored Transdisciplinary Research Centers, 2009 March of Dimes – Johnson and Johnson Foundation

Slide 27: 

There is so much more that needs to be done… So that one day…All babies will be born healthy!!