logging in or signing up Signal Transduction aSGuest19656 Download Post to : URL : Related Presentations : Let's Connect Share Add to Flag Embed Email Send to Blogs and Networks Add to Channel Copy embed code: Embed: Flash iPad Dynamic Copy Does not support media & animations Automatically changes to Flash or non-Flash embed WordPress Embed Customize Embed URL: Copy Thumbnail: Copy The presentation is successfully added In Your Favorites. Views: 3652 Category: Education License: All Rights Reserved Like it (0) Dislike it (0) Added: May 31, 2009 This Presentation is Public Favorites: 2 Presentation Description No description available. Comments Posting comment... Premium member Presentation Transcript Basics of Signal Transduction : Basics of Signal Transduction What is signal transduction? : What is signal transduction? Slide 3: Signaling is responsible for how cells can respond to their environment and how they can differentiate or change over time Objectives : Objectives Know the basics concepts of signal transduction Know specific mechanisms Membrane Receptor mediated (very diverse group) G-protein coupled Ion channel-linked Enzyme linked (example will be Receptor Tyrosine Kinases) Receptors that link to proteases Non-membrane receptor mediated pathways NO pathway Steroid hormone receptors Basic concepts : Basic concepts The same signal can induce different responses in different target cells Different combinations of signals induce different responses Responses can be fast or slow Signals are mediated by two types of receptors Signals are relayed and amplified Slide 6: Signals get translated into cellular responses or changes in gene expression Slide 7: Not all of the receptor needs to be bound to induce a response Slide 8: Signals can act locally or at a distance Basic types of signaling : Basic types of signaling Slide 11: The same signal can produce a different response in different targets Different combinations of signals induce different responses : Different combinations of signals induce different responses Responses can be fast or slow : Responses can be fast or slow Signals are mediated by two types of receptors : Signals are mediated by two types of receptors Slide 15: Signals are amplified Major components of signaling pathways : Major components of signaling pathways Signals Receptors G-proteins Protein kinases Protein phosphatases Second messenger producing components Signaling is very conserved : The same machinery is used in many different signaling pathways Different cell types will use the same machinery for different purposes Signaling is very conserved Slide 18: Proteins involved in signaling are conserved What are signals? : What are signals? Extracellular and intracellular Extracellular signals : Extracellular signals Physical Light, heat, touch, magnetic, electric Chemical Growth factors, hormones, nutrients, environmental cues Typically these initiate an action Slide 21: No receptor - no response Receptors determine response Intracellular signals : Intracellular signals We will focus on intracellular signals Secondary messengers Other types of signals (will see later) Typically these propagate or amplify an extracellular signal Some mediate internal signals Slide 23: Small organic molecules as signals Calcium can also be a signal Other types of signals : Other types of signals Changes in phosphorylation states Changes in ionic (Vm) composition Changes in what a protein is bound to Changes in protein structure Extracellular signal receptors : Extracellular signal receptors And the machinery that transmits their signals Membrane bound receptors come in different forms : Membrane bound receptors come in different forms Machinery we will see : Machinery we will see G-proteins Protein kinases Protein phosphatases Second messenger producing components You do not have the permission to view this presentation. In order to view it, please contact the author of the presentation.