asthma

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1 CURRENT STUDIES ON ASTHMA

INTRODUCTION TO ASTHMA : 

2 INTRODUCTION TO ASTHMA Asthma is a chronic inflammatory disorder of the airways in which many cells & cellular elements play a role (mast cells, eosinophils, T lymphocytes, macrophages, neutrophils, & epithelial cells). In susceptible individuals , inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night/early morning. These episodes are associated with variable airflow obstruction often reversible spontaneously/treatment

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3 REASON OF ASTHMA I

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4 DIFFERENCE BETWEEN NORMAL AND ASTHMATIC PERSON Airways narrow, caused by: tightening of the muscles that surround the airways swelling of the inner lining, and/or increase in mucus production

CAUSES : 

CAUSES 5 ENVIRONMENTAL GENETIC B2AR is located on chromosome 5q GENE-ENVIRONMENT INTERACTIONS CD14-ENDOTOXIN REACTIONS ALLERGENS POLLUTION

Pathophysiology : 

Pathophysiology 6 Inflammation Bronchial smooth muscle Hypertrophy + Mucous glands Hypertrophy Thick mucous Plugging of small airway (bronchoconstriction) Hyper responsiveness to triggers Long period (chronicity)

PHARMACOLOGY : 

PHARMACOLOGY

TRICKS TO COUNTER ASTHMA- : 

TRICKS TO COUNTER ASTHMA- DIAGNOSE- AT CORRECT TIME PREVENTION- FROM CAUSATIVE AGENTS AND EVENTS TREATMENT- SELECTION OF BEST SUITABLE COURSES EMRGENCY- OPT INHALATIONAL QUICK RELIEF DRUGS 8

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9 Asthma is a problem worldwide, with an estimated 300 million affected individuals Prevalence increasing in many countries, especially in children A cause of a significant number of preventable deaths A major cause of school/work absence EPIDEMIOLOGY

FUTURE SCOPE : 

FUTURE SCOPE The current 'gold standard' of asthma therapy is a combination inhaler containing a long-acting 2-agonist with a corticosteroid – an improved form of adrenal gland extract. Cromoglycate, derived from a plant product and theophylline, a dietary methyl xanthine, has also been extensively used in the therapy of asthma. 10 SO WE SHOULD HOPE FOR A BETTER SCOPE

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11 QUESTIONS ??