Behçet's disease

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a rare immune-mediated systemic vasculitis that often presents with mucous membrane ulceration and ocular involvements.

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In the name of Allah : 

In the name of Allah N.Mirzaei Ilali

PowerPoint Presentation: 

Clinical manifestations of Behçet's disease

Behçet's disease : 

Behçet's disease Behçet's disease (BEH- chets ) , sometimes called Behçet's syndrome , Morbus Behçet , or Silk Road disease. Behçet's disease is a rare immune-mediated systemic vasculitis that often presents with mucous membrane ulceration and ocular involvements.

PowerPoint Presentation: 

Behçet's disease (BD) was named in 1937 after the Turkish dermatologist Hulusi Behçet , who first described the triple-symptom complex of recurrent oral aphthous ulcers genital ulcers uveitis

recurrent oral aphthous ulcers : 

recurrent oral aphthous ulcers

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As a systemic disease, it can also involve visceral organs such as the gastrointestinal tract pulmonary musculoskeletal and neurological systems This syndrome can be fatal due to ruptured vascular aneurysms or severe neurological complications.

Skin and mucosa : 

Skin and mucosa aphthous ulcers inflammatory bowel disease erythema nodosum pyoderma gangrenosum

aphthous ulcers: 

aphthous ulcers

inflammatory bowel disease : 

inflammatory bowel disease

erythema nodosum: 

erythema nodosum

pyoderma gangrenosum : 

pyoderma gangrenosum

Ocular system : 

Ocular system posterior uveitis , anterior uveitis , or retinal vasculitis

Bowels : 

Bowels GI manifestations include abdominal pain, nausea, and diarrhea with or without blood, and they often involve the ileocecal valve. Many patients with BD often complain about abdominal tenderness, bloating, and generic abdominal discomfort that closely mimics irritable bowel syndrome.

Lungs : 

Lungs Lung involvement is typically in the form of hemoptysis , pleuritis , cough, or fever, and in severe cases can be life threatening if the outlet pulmonary artery develops an aneurysm which ruptures causing severe vascular collapse and death from bleeding in the lungs

Musculoskeletal system : 

Musculoskeletal system Arthralgia is seen in up to half of patients, and is usually a non-erosive poly or oligoarthritis primarily of the large joints of the lower extremities

Neurological system : 

Neurological system Neurological involvements range from aseptic meningitis to vascular thrombosis such as dural sinus thrombosis and organic brain syndrome manifesting with confusion, seizures, and memory loss They often appear late in the progression of the disease but are associated with a poor prognosis.