Parkinson’s Disease

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Parkinson’s Disease:

Parkinson’s Disease A disorder in the central nervous system that affects 4 million people world wide

PARKINSON’S DISEASE is a progressively degenerative neurological disorder that affects the control of body movements. :

PARKINSON’S DISEASE is a progressively degenerative neurological disorder that affects the control of body movements.

The Cause :

The Cause The motor symptoms of Parkinson's disease is the result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain; the cause of this cell death is unknown. DOPAMINE is a neurotransmitter which function in the brain includes voluntary movement, sleep , mood, attention, working memory, and learning. THAT is the SUBSTANTIA NIGRA

the Substantia Nigra controls BALANCE and MOVEMENT.:

the Substantia Nigra controls BALANCE and MOVEMENT. t he first Symptoms for Parkinson’s disease is TREMBLING and SHAKING, since the person lacks DOPAMINE GENERATING CELLS giving INVOLUNTARY MOVEMENT. Shaking Begins in One Hand Then to Arms, Legs, and Feet. Another Symptom is a Rigid body And an UNBALANCED BODY.

PARKINSON’S DISEASE:

PARKINSON’S DISEASE Affects 4 Million People worldwide and approximately 13 per 100,000 people and about 50,000 new cases are identified each year. Flexed walking posture is an effect of Parkinson’s disease.

Treatment:

Treatment The current treatment can significantly hide people’s symptoms The treatment for Parkinson's requires an accurate diagnosis. This is tricky, particularly early in the disorder when distinguishing Parkinson's disease from other diseases with similar symptoms. There is no known cure for Parkinson's disease. The goal of treatment is to control symptoms.

GENETIC COMPONENT:

GENETIC COMPONENT MOST cases of Parkinson disease occur in people with no apparent history of the disorder in their family. Approximately 15 percent of people with Parkinson disease have a family history of this disorder. Although the cause of these cases remains unclear, sporadic cases probably result from a complex interaction of environmental and genetic factors.

THESE FAMILIAL CASES:

THESE FAMILIAL CASES are caused by mutations in the LRRK2, PARK2, PARK7, PINK1, or SNCA gene, or by alterations in genes In some families, alterations in the GBA, SNCAIP, or UCHL1 gene appear to modify the risk of developing Parkinson disease .

the inheritance pattern differs depending on the gene that is altered:

the inheritance pattern differs depending on the gene that is altered At this point there is no established karyotype of Parkinson's Disease.

Parkinson’s Disease:

Parkinson’s Disease is inherited in an autosomal recessive pattern if the PARK2, PARK7, or PINK1 gene is involved. AUTOSOMAL- Referring to a chromosome that is not a sex chromosome.

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It is unclear whether these mutations are related to Parkinson disease, and the inheritance pattern is unknown.

PowerPoint Presentation:

Picture in SLIDE 3 taken from WIKIPEDIA/Parkinson’s disease Picture in SLIDE 5 taken from WIKIPEDIA/Parkinson’s disease Background in SLIDE 8 taken from GOOGLE IMAGES search GENETIC CODE Background in SLIDE 9 taken from GOOGLE IMAGES search PARKINSON’S PEDIGREE Picture in SLIDE 10 taken from GOOGLE IMAGES search PARKINSON’S GENE