GOUT PPT

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What is gout? Gout is painful condition that results the formation of uric acid crystals depositing in especially joints and tissues of the body causes inflammation.

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Gout is also defiened as pepripheral arthritis. Gout attacks are characterized by a rapid onset of pain in the affected joint followed by warmth, swelling, reddish discoloration, and marked tenderness

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What Cause Gout Pain? Uric acid causes gout pain. Too much uric acid in the blood will cause crystals to form in joints and other body tissues. Uric acid can cause gout attack, kidney stones, and blockage of the kidney filtering tubules with uric acid crystals, leading to kidney failure.

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Hyperuricemia High level of Uric Acid in blood serum is called “Hyperuricemia”. It caused by two factors : The kidneys cannot able to remove uric acid fast enough. The body makes too much uric acid High level of Uric Acid in blood can cause “Needle-Shaped” Mono Sodium Urate crystals in the joints as well as kidney. Uric acid is the end product of purine catabolism .

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MSU Crystals forms in synovial fluid when its solubility exceeded Ionised form of Uric acid is readly forms salts (MSU).

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Uric acid is produced by Xanthine and Hypoxanthine by Xanthine Oxidase Inhibitor. Uric Acid is more toxic than either xanthine or hypoxanthine. The normal range of Uric Acid in blood is between 3.6 mg/dL and 8.3 mg/dL The normal range of Uric Acid in is between 600-800 mg

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Purine Adenine Guanine Purine is a Hetrocyclic compound. Purine ring is more complex than the Pyrimidine ring. Purine is considered to be the fusion of Pyrimidine ring with Imidazole ring. Adenine and Guanine are the two principal purines found in both DNA & RNA.

Purine Bases:

Purine Bases

PURINE RICH FOODS:

PURINE RICH FOODS Organ meat (liver, kidney), shellfish, red meat, beef, pork. Alcohol , beer, soft drinks. Green peas, dried peas, beans, spinach, mushrooms. Creamy sauces and anchovies, lentils. Theophylline, Theobromine , Caffine .

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A typical gout symptom includes: Rapid severe pain in the big toe is the most common gout symptom. The affected joints can become very tender and swollen, and can feel warm. The skin on the joint turns reddish. Other joints that can be affected include the ankles, knees, wrists, fingers, and elbows. The inflammation from the uric crystals can lead to bursitis SIGN AND SYMPTOMS

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They form deposits that are sometimes apparent as firm lumps (tophi) under the skin. Tophi often are found in or near severely affected joints, on or near the elbow, over the fingers and toes, and in the outer edge of the ear. Chronic gout also has symptoms. These are shown as white nodules under the skin. These nodules are called tophi. These are collections of uric acid concentrations in the skin.

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Heredity Surgery. Dehydration. Obesity is also a risk factor. , excessive weight gain. Excessive alcohol consumption, and purines rich foods. Gender & Age Medications can also be causes of gout. Diuretics especially. High BP & abnormal Kidney Formation. RISK FACTORS OF GOUT

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Avoid purine rich foods, Reducing alcohol consumption It can make your condition worse. Avoid Diuretic Drugs. . Maintain the concentration of Uric Acid level within the normal range. Drinking Plenty of Water. Balance your weight with proper diet and exercise

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Foods known to decrease the occurrence of gout include dairy, foods high in potassium, black cherry juice, blueberries and lemon juice. Immediately treating gout will not allow it worse.

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How is gout diagnosed? Physical examination & medical history Measuring Uric Acid level in blood Analysis of Synovial Fluid Radio Therapy

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To lower the uric acid level in blood Increasing the excretion of uric acid (Uricosuric Drugs). b) Decreasing the synthesis of uric acid (Enzyme Inhibitor). c) Increasing the oxidation of uric acid (Urate Oxidase).

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An Uricosuric agent is one that enhances the renal excretion of uric acid. Sodium Salicillate Probenecid Sulfinpyrazone Phenyl Butazone Uricosuric Drugs

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It is competitive Enzyme Inhibitor of Xanthine oxidase. It resembles the chemical structure of Hypoxanthine. Allopurinol metabolized to corresponding xanthine analogue Oxipurinol . Allopurino l 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one .

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BRAND NAME: Zyloprim, Aloprim, Lopurin, Zurinol, Purinol

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THANK YOU